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Aliases for TBCA Gene

Aliases for TBCA Gene

  • Tubulin Folding Cofactor A 2 3 5
  • Tubulin-Specific Chaperone A 2 3
  • TCP1-Chaperonin Cofactor A 3 4
  • CFA 3 4
  • Tubulin-Folding Cofactor A 4
  • Chaperonin Cofactor A 3

External Ids for TBCA Gene

Previous GeneCards Identifiers for TBCA Gene

  • GC05M075792
  • GC05M077221
  • GC05M077025
  • GC05M077071
  • GC05M077022
  • GC05M072194

Summaries for TBCA Gene

Entrez Gene Summary for TBCA Gene

  • The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TBCA Gene

TBCA (Tubulin Folding Cofactor A) is a Protein Coding gene. Diseases associated with TBCA include Hypoparathyroidism-Retardation-Dysmorphism Syndrome. Among its related pathways are Metabolism of proteins and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for TBCA Gene

  • Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Gene Wiki entry for TBCA Gene

Additional gene information for TBCA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCA Gene

Genomics for TBCA Gene

GeneHancer (GH) Regulatory Elements for TBCA Gene

Promoters and enhancers for TBCA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J077774 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663.6 +93.2 93244 3.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 TBCA PIR43480 LOC105379045 OTP
GH05J077869 Enhancer 0.8 UCNEbase 650.7 -0.6 -564 0.4 OSR2 CTBP1 PKNOX1 PRDM6 ZSCAN5C MZF1 PRDM4 SP7 GC05P077869 TBCA LOC101929154 GC05P077817
GH05J077868 Enhancer 0.6 UCNEbase dbSUPER 650.7 -0.1 -82 0.2 GC05P077869 TBCA GC05P077817
GH05J077946 Enhancer 1.1 UCNEbase dbSUPER 12 -77.9 -77922 0.3 CTCF PKNOX1 ZNF680 INSM2 ZBTB8A FOXA1 OSR2 CTBP1 PRDM6 GATA3 ENSG00000253572 TBCA LOC101929154 TRQ-TTG7-1
GH05J077935 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.5 -67.3 -67337 0.6 CBFB CEBPB EBF1 CEBPG ZNF518A ATF2 ZNF395 ATF4 FOXP2 TRIM24 TBCA ENSG00000253572 GC05M077895 LOC101929154
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBCA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBCA gene promoter:
  • LCR-F1
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • AML1a
  • GR-alpha
  • GR
  • Pbx1a
  • POU3F2
  • POU3F2 (N-Oct-5a)

Genomic Locations for TBCA Gene

Genomic Locations for TBCA Gene
177,615 bases
Minus strand
177,614 bases
Minus strand

Genomic View for TBCA Gene

Genes around TBCA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBCA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCA Gene

Proteins for TBCA Gene

  • Protein details for TBCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin-specific chaperone A
    Protein Accession:
    Secondary Accessions:
    • B4DT30

    Protein attributes for TBCA Gene

    108 amino acids
    Molecular mass:
    12855 Da
    Quaternary structure:
    • Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

    Three dimensional structures from OCA and Proteopedia for TBCA Gene

    Alternative splice isoforms for TBCA Gene


neXtProt entry for TBCA Gene

Post-translational modifications for TBCA Gene

  • Ubiquitination at posLast=105105 and isoforms=252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBCA Gene

Domains & Families for TBCA Gene

Gene Families for TBCA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TBCA Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TBCA family.
  • Belongs to the TBCA family.
genes like me logo Genes that share domains with TBCA: view

Function for TBCA Gene

Molecular function for TBCA Gene

UniProtKB/Swiss-Prot Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Phenotypes From GWAS Catalog for TBCA Gene

Gene Ontology (GO) - Molecular Function for TBCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 21044950
GO:0048487 beta-tubulin binding IEA --
GO:0051087 chaperone binding TAS 8706133
genes like me logo Genes that share ontologies with TBCA: view
genes like me logo Genes that share phenotypes with TBCA: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBCA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBCA Gene

Localization for TBCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBCA Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBCA gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TBCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm TAS,IEA 16130169
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with TBCA: view

Pathways & Interactions for TBCA Gene

genes like me logo Genes that share pathways with TBCA: view

Pathways by source for TBCA Gene

Gene Ontology (GO) - Biological Process for TBCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8706133
GO:0007021 tubulin complex assembly IEA --
GO:0007023 post-chaperonin tubulin folding pathway IEA --
genes like me logo Genes that share ontologies with TBCA: view

No data available for SIGNOR curated interactions for TBCA Gene

Drugs & Compounds for TBCA Gene

No Compound Related Data Available

Transcripts for TBCA Gene

mRNA/cDNA for TBCA Gene

Unigene Clusters for TBCA Gene

Tubulin folding cofactor A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBCA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBCA Gene

No ASD Table

Relevant External Links for TBCA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBCA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBCA Gene

Protein differential expression in normal tissues from HIPED for TBCA Gene

This gene is overexpressed in Lavage (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TBCA Gene

Protein tissue co-expression partners for TBCA Gene

NURSA nuclear receptor signaling pathways regulating expression of TBCA Gene:


SOURCE GeneReport for Unigene cluster for TBCA Gene:


Evidence on tissue expression from TISSUES for TBCA Gene

  • Blood(4.2)
  • Nervous system(3)
  • Liver(2.6)
  • Heart(2.5)
  • Kidney(2.5)
  • Muscle(2.5)
  • Spleen(2.5)
  • Lung(2.4)
  • Adrenal gland(2.1)
  • Intestine(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with TBCA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBCA Gene

Orthologs for TBCA Gene

This gene was present in the common ancestor of animals.

Orthologs for TBCA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBCA 34 33
  • 99.38 (n)
(Canis familiaris)
Mammalia TBCA 34 33
  • 90.98 (n)
(Bos Taurus)
Mammalia TBCA 34 33
  • 89.2 (n)
(Monodelphis domestica)
Mammalia TBCA 34
  • 88 (a)
(Mus musculus)
Mammalia Tbca 16 34 33
  • 87.04 (n)
(Rattus norvegicus)
Mammalia Tbca 33
  • 86.11 (n)
(Ornithorhynchus anatinus)
Mammalia TBCA 34
  • 86 (a)
(Gallus gallus)
Aves TBCA 34 33
  • 80.25 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
-- 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbca 33
  • 76.85 (n)
Str.691 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20053 33
(Danio rerio)
Actinopterygii tbca 34 33
  • 65.74 (n)
zgc56262 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12295 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002130 33
  • 59.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1890 34 33
  • 50.47 (n)
(Caenorhabditis elegans)
Secernentea Y39G10AR.20 34
  • 33 (a)
Species where no ortholog for TBCA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBCA Gene

Gene Tree for TBCA (if available)
Gene Tree for TBCA (if available)
Evolutionary constrained regions (ECRs) for TBCA: view image

Paralogs for TBCA Gene Pseudogenes for TBCA Gene

genes like me logo Genes that share paralogs with TBCA: view

No data available for Paralogs for TBCA Gene

Variants for TBCA Gene

Sequence variations from dbSNP and Humsavar for TBCA Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000013429 -- 77,754,185(-) T/C intron_variant
rs1000049539 -- 77,705,074(-) A/G intron_variant
rs1000053839 -- 77,725,786(-) C/A intron_variant
rs1000107723 -- 77,738,398(-) T/G intron_variant
rs1000216783 -- 77,777,459(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TBCA Gene

Variant ID Type Subtype PubMed ID
dgv3100n106 CNV deletion 24896259
dgv3101n106 CNV deletion 24896259
esv1483892 CNV deletion 17803354
esv2228193 CNV deletion 18987734
esv2538870 CNV deletion 19546169
esv2669417 CNV deletion 23128226
esv2730329 CNV deletion 23290073
esv2730330 CNV deletion 23290073
esv3302973 CNV tandem duplication 20981092
esv3566133 CNV deletion 23714750
esv3566135 CNV deletion 23714750
esv3605494 CNV loss 21293372
esv3605495 CNV loss 21293372
esv3605498 CNV loss 21293372
esv4231 CNV loss 18987735
esv7635 CNV loss 19470904
esv7921 CNV loss 19470904
esv989167 CNV deletion 20482838
nsv1073897 CNV deletion 25765185
nsv1074846 CNV deletion 25765185
nsv1148487 CNV deletion 26484159
nsv328235 CNV deletion 16902084
nsv477477 CNV novel sequence insertion 20440878
nsv823103 CNV loss 20364138

Variation tolerance for TBCA Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBCA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBCA Gene

Disorders for TBCA Gene

MalaCards: The human disease database

(1) MalaCards diseases for TBCA Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypoparathyroidism-retardation-dysmorphism syndrome
  • hrds
- elite association - COSMIC cancer census association via MalaCards
Search TBCA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TBCA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TBCA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TBCA Gene

Publications for TBCA Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner JT … Grant SF (American journal of human genetics 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TBCA Gene

Sources for TBCA Gene

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