Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAL2 Gene

Aliases for TAL2 Gene

  • TAL BHLH Transcription Factor 2 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 19 3 4
  • T-Cell Acute Lymphocytic Leukemia 2 2 3
  • TAL-2 3 4
  • T-Cell Acute Lymphocytic Leukemia Protein 2 3
  • BHLHA19 4
  • BHLHa19 4

External Ids for TAL2 Gene

Previous GeneCards Identifiers for TAL2 Gene

  • GC09P099225
  • GC09P100168
  • GC09P101882
  • GC09P103804
  • GC09P105504
  • GC09P107464
  • GC09P108424
  • GC09P078026

Summaries for TAL2 Gene

Entrez Gene Summary for TAL2 Gene

  • This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

GeneCards Summary for TAL2 Gene

TAL2 (TAL BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with TAL2 include Acute Lymphocytic Leukemia and Leukemia. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is TAL1.

Gene Wiki entry for TAL2 Gene

Additional gene information for TAL2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL2 Gene

Genomics for TAL2 Gene

GeneHancer (GH) Regulatory Elements for TAL2 Gene

Promoters and enhancers for TAL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J105609 Enhancer 0.6 ENCODE 11.6 -53.3 -53282 0.2 MEIS2 CTCF PKNOX1 ZNF654 TRIM22 DACH1 REST RAD21 ZNF592 SMC3 TAL2 GC09M105565 ENSG00000279609 FKTN
GH09J106054 Enhancer 0.2 FANTOM5 18.3 +392.2 392239 0.2 TAL2 ENSG00000225002 LOC105376201
GH09J105860 Enhancer 0.4 FANTOM5 6.4 +198.4 198416 0.3 MEIS2 TAL2 FSD1L SLC25A6P5 LOC105376201
GH09J105683 Enhancer 0.2 ENCODE 12.1 +21.6 21599 1.2 TMEM38B TAL2
GH09J105216 Enhancer 0.3 FANTOM5 1.6 -445.5 -445470 0.1 ZNF48 GC09P105218 SLC44A1 TAL2 FSD1L RN7SKP191
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAL2 gene promoter:
  • POU2F1
  • POU2F1a
  • Bach2
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • RORalpha1
  • FOXO1

Genomic Locations for TAL2 Gene

Genomic Locations for TAL2 Gene
656 bases
Plus strand
656 bases
Plus strand

Genomic View for TAL2 Gene

Genes around TAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL2 Gene

Proteins for TAL2 Gene

  • Protein details for TAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell acute lymphocytic leukemia protein 2
    Protein Accession:
    Secondary Accessions:
    • A0AVI7

    Protein attributes for TAL2 Gene

    108 amino acids
    Molecular mass:
    12291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAL2 Gene

Post-translational modifications for TAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAL2 Gene

Domains & Families for TAL2 Gene

Gene Families for TAL2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TAL2 Gene

Suggested Antigen Peptide Sequences for TAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TAL2: view

No data available for UniProtKB/Swiss-Prot for TAL2 Gene

Function for TAL2 Gene

Molecular function for TAL2 Gene

GENATLAS Biochemistry:
helix loop helix protein,homologous to TAL1,involved in T cell acute lymphoblastic leukemia,with translocation t(7;9)(q35;q34)

Phenotypes From GWAS Catalog for TAL2 Gene

Gene Ontology (GO) - Molecular Function for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA,ISM 19274049
GO:0003677 DNA binding TAS 1763056
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TAL2: view
genes like me logo Genes that share phenotypes with TAL2: view

Human Phenotype Ontology for TAL2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAL2 Gene

MGI Knock Outs for TAL2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TAL2 Gene

Localization for TAL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAL2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TAL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAL2 Gene

Pathways & Interactions for TAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0009791 post-embryonic development IEA --
GO:0021794 thalamus development IEA --
genes like me logo Genes that share ontologies with TAL2: view

No data available for Pathways by source and SIGNOR curated interactions for TAL2 Gene

Drugs & Compounds for TAL2 Gene

No Compound Related Data Available

Transcripts for TAL2 Gene

mRNA/cDNA for TAL2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAL2 Gene

T-cell acute lymphocytic leukemia 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAL2 Gene

No ASD Table

Relevant External Links for TAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL2 Gene

This gene is overexpressed in Muscle - Skeletal (x8.5).

NURSA nuclear receptor signaling pathways regulating expression of TAL2 Gene:


SOURCE GeneReport for Unigene cluster for TAL2 Gene:


Phenotype-based relationships between genes and organs from Gene ORGANizer for TAL2 Gene

Germ Layers:
  • mesoderm
  • immune
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with TAL2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for TAL2 Gene

Orthologs for TAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAL2 34 33
  • 100 (n)
(Canis familiaris)
Mammalia TAL2 34 33
  • 91.75 (n)
(Bos Taurus)
Mammalia TAL2 34 33
  • 90.16 (n)
(Mus musculus)
Mammalia Tal2 16 34 33
  • 86.11 (n)
(Rattus norvegicus)
Mammalia Tal2 33
  • 85.19 (n)
(Ornithorhynchus anatinus)
Mammalia TAL2 34
  • 80 (a)
(Monodelphis domestica)
Mammalia TAL2 34
  • 73 (a)
(Gallus gallus)
Aves TAL2 34
  • 70 (a)
(Anolis carolinensis)
Reptilia TAL2 34
  • 78 (a)
(Danio rerio)
Actinopterygii tal2 34 33
  • 60.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 34
  • 14 (a)
Species where no ortholog for TAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL2 Gene

Gene Tree for TAL2 (if available)
Gene Tree for TAL2 (if available)
Evolutionary constrained regions (ECRs) for TAL2: view image

Paralogs for TAL2 Gene

Paralogs for TAL2 Gene

(23) SIMAP similar genes for TAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAL2: view

Variants for TAL2 Gene

Sequence variations from dbSNP and Humsavar for TAL2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001649415 -- 105,661,684(+) T/C upstream_transcript_variant
rs1001701484 -- 105,661,946(+) C/G upstream_transcript_variant
rs1002036681 -- 105,663,081(+) TTTT/TT 3_prime_UTR_variant
rs1004313639 -- 105,663,039(+) G/A 3_prime_UTR_variant
rs1006768477 -- 105,663,553(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAL2 Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
esv3891707 CNV gain 25118596
nsv519023 CNV gain 19592680

Variation tolerance for TAL2 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL2 Gene

Disorders for TAL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TAL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
lymphoblastic leukemia
  • acute lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TAL2 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB. {ECO:0000269 PubMed:1763056}.

Genatlas disease for TAL2 Gene

acute lymphoblastic leukemia (T cell) with breakpoint in t(7;9)(q35;q34) translocation

Additional Disease Information for TAL2

Genetic Association Database
Tumor Gene Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TAL2: view

Publications for TAL2 Gene

  1. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. (PMID: 1763056) Xia Y … Baer RJ (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22 58
  2. Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. (PMID: 8152805) Xia Y … Baer R (Oncogene 1994) 3 4 22 58
  3. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 44 58
  4. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. (PMID: 19448620) Perry JR … Murabito JM (Nature genetics 2009) 3 44 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for TAL2 Gene

Sources for TAL2 Gene

Loading form....