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Aliases for TAL1 Gene

Aliases for TAL1 Gene

  • TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 17 3 4
  • T-Cell Acute Lymphocytic Leukemia 1 2 3
  • T-Cell Leukemia/Lymphoma Protein 5 3 4
  • Stem Cell Protein 3 4
  • BHLHa17 3 4
  • TCL5 3 4
  • SCL 3 4
  • T-Cell Acute Lymphocytic Leukemia Protein 1 3
  • Tal-1 Product 3
  • BHLHA17 4
  • Tal-1 3
  • TAL-1 4

External Ids for TAL1 Gene

Previous HGNC Symbols for TAL1 Gene

  • TCL5

Previous GeneCards Identifiers for TAL1 Gene

  • GC01M047308
  • GC01M046571
  • GC01M047040
  • GC01M047051
  • GC01M047393
  • GC01M047454
  • GC01M047681
  • GC01M045798

Summaries for TAL1 Gene

GeneCards Summary for TAL1 Gene

TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor) is a Protein Coding gene. Diseases associated with TAL1 include Precursor T-Cell Acute Lymphoblastic Leukemia and Acute Lymphocytic Leukemia. Among its related pathways are NF-kappaB Signaling and MAPK-Erk Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for TAL1 Gene

  • Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Wiki entry for TAL1 Gene

Additional gene information for TAL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL1 Gene

Genomics for TAL1 Gene

GeneHancer (GH) Regulatory Elements for TAL1 Gene

Promoters and enhancers for TAL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J047224 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 667.6 +3.5 3482 8.8 HDGF PKNOX1 SMAD1 ARNT YY1 POLR2B ZNF766 CBX5 E2F8 ZNF143 TAL1 LRRC41 PDZK1IP1 LINC01389 NSUN4 EFCAB14-AS1 FOXE3 ENSG00000226252
GH01J047233 Enhancer 0.7 ENCODE dbSUPER 650.7 -1.4 -1404 0.3 ATF1 HDAC2 SUZ12 HMBOX1 DPF2 TAL1 GC01M047285
GH01J047178 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 16.2 +51.5 51511 4.5 YBX1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 NBN LINC00853 CYP4A22-AS1 EFCAB14-AS1 LRRC41 PDZK1IP1 MOB3C TAL1 ENSG00000226252 CYP4B1 ENSG00000225028
GH01J047332 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 -101.9 -101916 4.2 HDGF SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 CMPK1 ENSG00000226252 FOXE3 TAL1 LINC01389 PDZK1IP1 FOXD2 GC01P047350
GH01J047188 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 12.9 +41.1 41138 4.5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PDZK1IP1 LRRC41 ENSG00000226252 TAL1 FOXE3 LINC01389 FOXD2 FOXD2-AS1 GC01M047220
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAL1 gene promoter:
  • AML1a

Genomic Locations for TAL1 Gene

Genomic Locations for TAL1 Gene
chr1:47,216,290-47,232,373
(GRCh38/hg38)
Size:
16,084 bases
Orientation:
Minus strand
chr1:47,681,962-47,697,892
(GRCh37/hg19)
Size:
15,931 bases
Orientation:
Minus strand

Genomic View for TAL1 Gene

Genes around TAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL1 Gene

Proteins for TAL1 Gene

  • Protein details for TAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17542-TAL1_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 1
    Protein Accession:
    P17542
    Secondary Accessions:
    • D3DQ24

    Protein attributes for TAL1 Gene

    Size:
    331 amino acids
    Molecular mass:
    34271 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.

    Three dimensional structures from OCA and Proteopedia for TAL1 Gene

    Alternative splice isoforms for TAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAL1 Gene

Post-translational modifications for TAL1 Gene

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
  • Ubiquitination at isoforms=3, 2241, posLast=234234, and isoforms=2185
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TAL1

No data available for DME Specific Peptides for TAL1 Gene

Domains & Families for TAL1 Gene

Gene Families for TAL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TAL1 Gene

Suggested Antigen Peptide Sequences for TAL1 Gene

Graphical View of Domain Structure for InterPro Entry

P17542

UniProtKB/Swiss-Prot:

TAL1_HUMAN :
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
Domain:
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
genes like me logo Genes that share domains with TAL1: view

Function for TAL1 Gene

Molecular function for TAL1 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Phenotypes From GWAS Catalog for TAL1 Gene

Gene Ontology (GO) - Molecular Function for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM,IEA 19274049
genes like me logo Genes that share ontologies with TAL1: view
genes like me logo Genes that share phenotypes with TAL1: view

Human Phenotype Ontology for TAL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAL1 Gene

MGI Knock Outs for TAL1:

Animal Model Products

Transcription Factor Targets for TAL1 Gene

Selected GeneGlobe predicted Target genes for TAL1
Targeted motifs for TAL1 Gene
HOMER Transcription Factor Regulatory Elements motif TAL1
  • Consensus sequence: ANCAGCTG Submotif: canonical Cell Type: HPC7 GEO ID: GSE13511

Clone Products

  • Addgene plasmids for TAL1

No data available for Enzyme Numbers (IUBMB) for TAL1 Gene

Localization for TAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAL1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 19497860
GO:0000790 nuclear chromatin IDA 20855495
GO:0005634 nucleus IDA 19497860
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA,IDA 15920471
genes like me logo Genes that share ontologies with TAL1: view

Pathways & Interactions for TAL1 Gene

genes like me logo Genes that share pathways with TAL1: view

Pathways by source for TAL1 Gene

1 Sino Biological pathway for TAL1 Gene
1 Cell Signaling Technology pathway for TAL1 Gene

SIGNOR curated interactions for TAL1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,ISS --
genes like me logo Genes that share ontologies with TAL1: view

Drugs & Compounds for TAL1 Gene

(2) Drugs for TAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAL1: view

Transcripts for TAL1 Gene

mRNA/cDNA for TAL1 Gene

Unigene Clusters for TAL1 Gene

T-cell acute lymphocytic leukemia 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TAL1

Alternative Splicing Database (ASD) splice patterns (SP) for TAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - - - - -
SP4:

Relevant External Links for TAL1 Gene

GeneLoc Exon Structure for
TAL1
ECgene alternative splicing isoforms for
TAL1

Expression for TAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL1 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for TAL1 Gene

This gene is overexpressed in Liver (62.4) and Fetal Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAL1 Gene



Protein tissue co-expression partners for TAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAL1 Gene:

TAL1

SOURCE GeneReport for Unigene cluster for TAL1 Gene:

Hs.705618

mRNA Expression by UniProt/SwissProt for TAL1 Gene:

P17542-TAL1_HUMAN
Tissue specificity: Leukemic stem cell.

Evidence on tissue expression from TISSUES for TAL1 Gene

  • Bone marrow(4.5)
  • Blood(3.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TAL1 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with TAL1: view

Orthologs for TAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAL1 34 33
  • 99.9 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAL1 34 33
  • 90.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAL1 34 33
  • 90.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tal1 16 34 33
  • 88.75 (n)
rat
(Rattus norvegicus)
Mammalia Tal1 33
  • 88.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAL1 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAL1 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCL 34
  • 82 (a)
OneToOne
TAL1 33
  • 72.46 (n)
lizard
(Anolis carolinensis)
Reptilia TAL1 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tal1 33
  • 68.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398028 33
zebrafish
(Danio rerio)
Actinopterygii tal1 34 33 33
  • 68.73 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12172 33
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 34
  • 19 (a)
OneToMany
Species where no ortholog for TAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL1 Gene

ENSEMBL:
Gene Tree for TAL1 (if available)
TreeFam:
Gene Tree for TAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAL1: view image

Paralogs for TAL1 Gene

Paralogs for TAL1 Gene

(4) SIMAP similar genes for TAL1 Gene using alignment to 3 proteins:

  • TAL1_HUMAN
  • E7EVM2_HUMAN
  • L8E8Z6_HUMAN
genes like me logo Genes that share paralogs with TAL1: view

Variants for TAL1 Gene

Sequence variations from dbSNP and Humsavar for TAL1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000051743 -- 47,229,029(-) A/C intron_variant
rs1000285429 -- 47,216,411(-) C/A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000346723 -- 47,222,290(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000718576 -- 47,217,591(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000947154 -- 47,223,946(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAL1 Gene

Variant ID Type Subtype PubMed ID
nsv475889 CNV novel sequence insertion 20440878
nsv475925 CNV novel sequence insertion 20440878

Variation tolerance for TAL1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAL1 Gene

Human Gene Mutation Database (HGMD)
TAL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL1 Gene

Disorders for TAL1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TAL1 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
t-cell leukemia
  • leukemia t-cell
immunodeficiency 18
  • imd18
- elite association - COSMIC cancer census association via MalaCards
Search TAL1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAL1_HUMAN
  • Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. {ECO:0000269 PubMed:2303035}.

Genatlas disease for TAL1 Gene

acute lymphoblastic leukemia (T cell) with interstitial deletion 5 to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA

Additional Disease Information for TAL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TAL1: view

Publications for TAL1 Gene

  1. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. (PMID: 8437851) Cheng JT … Baer R (Oncogene 1993) 3 4 22 58
  2. The SCL gene product: a positive regulator of erythroid differentiation. (PMID: 1396592) Aplan PD … Kirsch IR (The EMBO journal 1992) 3 4 22 58
  3. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. (PMID: 2230650) Chen Q … Baer R (The Journal of experimental medicine 1990) 3 4 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. (PMID: 19865112) Carbuccia N … Mozziconacci MJ (Leukemia 2010) 3 44 58

Products for TAL1 Gene

  • Addgene plasmids for TAL1

Sources for TAL1 Gene

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