MAP3K7 Gene (Protein Coding)

Mitogen-Activated Protein Kinase Kinase Kinase 7

GC06M090513
GIFtS:
51
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3... See more...

Aliases for MAP3K7 Gene

Aliases for MAP3K7 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 7 2 3 4 5
  • Transforming Growth Factor-Beta-Activated Kinase 1 3 4
  • TGF-Beta Activated Kinase 1 2 3
  • EC 2.7.11.25 4 51
  • MEKK7 2 3
  • TAK1 3 4
  • TGF-Beta-Activated Kinase 1 4
  • EC 2.7.11 51
  • MAP3K7 5
  • TGF1a 3
  • CSCF 3
  • FMD2 3

External Ids for MAP3K7 Gene

Previous HGNC Symbols for MAP3K7 Gene

  • TAK1

Previous GeneCards Identifiers for MAP3K7 Gene

  • GC06M091171
  • GC06M091220
  • GC06M091282
  • GC06M088444

Summaries for MAP3K7 Gene

Entrez Gene Summary for MAP3K7 Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K7 Gene

MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7) is a Protein Coding gene. Diseases associated with MAP3K7 include Cardiospondylocarpofacial Syndrome and Frontometaphyseal Dysplasia 2. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Signal transduction_JNK pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K7CL.

UniProtKB/Swiss-Prot Summary for MAP3K7 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity).

Tocris Summary for MAP3K7 Gene

Gene Wiki entry for MAP3K7 Gene

Additional gene information for MAP3K7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K7 Gene

Genomics for MAP3K7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAP3K7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K7

Top Transcription factor binding sites by QIAGEN in the MAP3K7 gene promoter:
  • Sox9
  • STAT3

Genomic Locations for MAP3K7 Gene

Genomic Locations for MAP3K7 Gene
chr6:90,513,573-90,587,072
(GRCh38/hg38)
Size:
73,500 bases
Orientation:
Minus strand
chr6:91,223,292-91,296,907
(GRCh37/hg19)
Size:
73,616 bases
Orientation:
Minus strand

Genomic View for MAP3K7 Gene

Genes around MAP3K7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP3K7 Gene

Proteins for MAP3K7 Gene

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  • Protein details for MAP3K7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43318-M3K7_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 7
    Protein Accession:
    O43318
    Secondary Accessions:
    • B2RE27
    • E1P523
    • O43317
    • O43319
    • Q5TDN2
    • Q5TDN3
    • Q5TDT7
    • Q9NTR3
    • Q9NZ70

    Protein attributes for MAP3K7 Gene

    Size:
    606 amino acids
    Molecular mass:
    67196 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Can form homodimer (PubMed:27426733). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1, TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3 (PubMed:10838074, PubMed:11460167, PubMed:12242293, PubMed:14670075, PubMed:16289117, PubMed:19675569, PubMed:8638164). Identified in the TRIKA2 complex composed of MAP3K7/TAK1, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 (PubMed:11460167). Interacts with PPM1L and PPM1B/PP2CB (PubMed:11104763). Interaction with PP2A and PPP6C leads to its repressed activity (PubMed:17079228). Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling (PubMed:10094049, PubMed:12242293). Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation (PubMed:16893890). Interacts with WDR34 (via WD domains) (PubMed:19521662). Interacts with CYLD and RBCK1 (PubMed:17449468, PubMed:17548520). Interacts with TGFBR1; induces MAP3K7/TAK1 activation by TRAF6 (PubMed:18758450). Interacts with MAPK8IP1 and SMAD6 (By similarity). Interacts with isoform 1 of VRK2 (PubMed:18286207). Interacts with DAB2; the interaction is induced by TGF-beta stimulation and may mediate TGF-beta stimulated JNK activation (PubMed:15894542). Interacts with TRIM5 (PubMed:21512573). Part of a complex containing ITCH, NDFIP1 and MAP3K7 (By similarity). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with TRIM8 (PubMed:22084099). Found in a complex with SH3RF1, RAC2, MAP2K7/MKK7, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2 (By similarity). Interacts with SASH1 (PubMed:23776175). Interacts with RIPK1 (By similarity).
    • (Microbial infection) Interacts with herpes simplex virus 2 protein US2; this interaction induces MAP3K7 phosphorylation and subsequent activation.

    Three dimensional structures from OCA and Proteopedia for MAP3K7 Gene

    Alternative splice isoforms for MAP3K7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K7 Gene

Protein Expression for MAP3K7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAP3K7 Gene

O43318:
  • GSAAWMAPEVFEGS
  • VGRGAFG
  • GNGQPRRRSIQDLTVTGT
  • YSEKCDV
  • LKICDFG
  • NHPNIVKL

Post-translational modifications for MAP3K7 Gene

  • Association with TAB1/MAP3K7IP1 promotes autophosphorylation at Ser-192 and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Ser-192 by PPM1B/PP2CB and at Thr-187 by PP2A and PPP6C leads to inactivation.
  • 'Lys-48'-linked polyubiquitination at Lys-72 is induced by TNFalpha, and leads to proteasomal degradation. Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH (By similarity). Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.
  • (Microbial infection) Cleaved and inactivated by the proteases 3C of coxsackievirus A16 and human enterovirus D68, allowing the virus to disrupt TRAF6-triggered NF-kappa-B induction.
  • Ubiquitination at Lys72, Lys158, Lys209, and Lys547
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP3K7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAP3K7

Domains & Families for MAP3K7 Gene

Gene Families for MAP3K7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for MAP3K7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP3K7 Gene

GenScript: Design optimal peptide antigens:
  • Transforming growth factor-beta-activated kinase 1 (M3K7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43318

UniProtKB/Swiss-Prot:

M3K7_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K7: view

Function for MAP3K7 Gene

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  2. CRISPR
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Molecular function for MAP3K7 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:12589052};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:12589052};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by proinflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation. Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 promotes activation through autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C dephosphorylation leads to inactivation.
GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 7,widely expressed,activated by MAP4K4 (see symbol) in JNK signaling pathway,involved in the BMP signaling through binding with API3 (XIAP)3,also associating with TRAF6 during IL-1 signaling and activating NFKB

Enzyme Numbers (IUBMB) for MAP3K7 Gene

Phenotypes From GWAS Catalog for MAP3K7 Gene

Gene Ontology (GO) - Molecular Function for MAP3K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IDA 10094049
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004709 MAP kinase kinase kinase activity IEA,IDA 11460167
genes like me logo Genes that share ontologies with MAP3K7: view
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Human Phenotype Ontology for MAP3K7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP3K7

CRISPR Products

miRNA for MAP3K7 Gene

miRTarBase miRNAs that target MAP3K7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K7

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K7 Gene

Localization for MAP3K7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K7 Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endosome 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,IDA --
genes like me logo Genes that share ontologies with MAP3K7: view

Pathways & Interactions for MAP3K7 Gene

PathCards logo

SuperPathways for MAP3K7 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
activated TAK1 mediates p38 MAPK activation
.01
IRAK2 mediated activation of TAK1 complex
.01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
.01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
TRAF6 mediated induction of TAK1 complex
.01
2 Toll-Like receptor Signaling Pathways
NOD-like Receptor Signaling Pathways
.59
Toll-Like receptor Signaling Pathways
.59
IL-1 Family Signaling Pathways
.43
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
3 TNFR1 Pathway
TNFR1 Pathway
.56
TNF Signaling
.55
Death Receptor Signaling
.36
TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
.34
TNF alpha Signaling Pathway
.30
4 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Hepatitis B
.37
5 IL-17 Family Signaling Pathways
IL-17 Family Signaling Pathways
.51
IL17 signaling pathway
.51
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
IL-17 signaling pathway
.33
genes like me logo Genes that share pathways with MAP3K7: view

Pathways by source for MAP3K7 Gene

1 PharmGKB pathway for MAP3K7 Gene
17 GeneGo (Thomson Reuters) pathways for MAP3K7 Gene
  • Bacterial infections in CF airways
  • Cell adhesion Ephrins signaling
  • Cell adhesion_Plasmin signaling
  • Cell cycle Role of 14-3-3 proteins in cell cycle regulation
  • Cytokine production by Th17 cells in CF
31 Qiagen pathways for MAP3K7 Gene
  • APRIL Pathway
  • BAFF in B-Cell Signaling
  • BMP Pathway
  • Cardiomyocyte Differentiation through BMP Receptors
  • CD40 Signaling
3 Cell Signaling Technology pathways for MAP3K7 Gene
2 GeneTex pathways for MAP3K7 Gene

SIGNOR curated interactions for MAP3K7 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAP3K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity IEA,IDA 8663074
GO:0000187 activation of MAPK activity TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002726 positive regulation of T cell cytokine production IMP 15125833
genes like me logo Genes that share ontologies with MAP3K7: view

Drugs & Compounds for MAP3K7 Gene

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  1. Drug

(12) Drugs for MAP3K7 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
RGB-286638 Pharma 0

(5) Additional Compounds for MAP3K7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with MAP3K7: view

Transcripts for MAP3K7 Gene

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mRNA/cDNA for MAP3K7 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

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Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5: -
SP6:
SP7: - - - - - -

ExUns: 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MAP3K7 Gene

GeneLoc Exon Structure for
MAP3K7

Expression for MAP3K7 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K7 Gene

mRNA expression in normal human tissues for MAP3K7 Gene
mRNA expression by GTEx for MAP3K7 GenemRNA expression by BioGPS for MAP3K7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP3K7 Gene

This gene is overexpressed in Testis (13.4) and Peripheral blood mononuclear cells (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K7 Gene



Protein tissue co-expression partners for MAP3K7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K7

SOURCE GeneReport for Unigene cluster for MAP3K7 Gene:

Hs.594838

mRNA Expression by UniProt/SwissProt for MAP3K7 Gene:

O43318-M3K7_HUMAN
Tissue specificity: Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.

Evidence on tissue expression from TISSUES for MAP3K7 Gene

  • Lung(4.5)
  • Blood(4.5)
  • Liver(4.5)
  • Nervous system(4.5)
  • Kidney(2.9)
  • Heart(2.7)
  • Spleen(2.7)
  • Muscle(2.6)
  • Lymph node(2.6)
  • Intestine(2.6)
  • Skin(2.6)
  • Bone marrow(2.3)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with MAP3K7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K7 Gene

Orthologs for MAP3K7 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K7 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
 Mammalia MAP3K7 31
  • 100 (a)
 OneToOne
LOC102156745 30
  • 97.08 (n)
Chimpanzee
(Pan troglodytes)
 Mammalia MAP3K7 30 31
  • 99.61 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Map3k7 31
  • 99 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAP3K7 31
  • 98 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 96 (a)
 OneToMany
-- 31
  • 81 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia MAP3K7 30 31
  • 94.8 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Map3k7 30
  • 91.86 (n)
Chicken
(Gallus gallus)
 Aves MAP3K7 30 31
  • 85.17 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAP3K7 31
  • 89 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia map3k7 30
  • 83.15 (n)
Str.3144 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.274 30
Zebrafish
(Danio rerio)
 Actinopterygii map3k7 31
  • 76 (a)
 OneToOne
Dr.17131 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12347 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Takl2 31 32
  • 42 (a)
 OneToMany
Takl1 31 32
  • 33 (a)
 OneToMany
Tak1 31 32
  • 31 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea mom-4 32
  • 32 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 50 (a)
 OneToOne
Species where no ortholog for MAP3K7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAP3K7 Gene

ENSEMBL:
Gene Tree for MAP3K7 (if available)
TreeFam:
Gene Tree for MAP3K7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP3K7: view image

Paralogs for MAP3K7 Gene

Paralogs for MAP3K7 Gene

(1) SIMAP similar genes for MAP3K7 Gene using alignment to 1 proteins:

  • M3K7_HUMAN
genes like me logo Genes that share paralogs with MAP3K7: view

Variants for MAP3K7 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K7 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
639687 Uncertain Significance: not provided 90,571,698(-) T/G MISSENSE_VARIANT
684731 Likely Pathogenic: Cardiospondylocarpofacial syndrome 90,571,800(-) CCAA/C INFRAME_DELETION
689611 Uncertain Significance: Cardiospondylocarpofacial syndrome 90,568,607(-) C/T MISSENSE_VARIANT
712638 Benign: not provided 90,550,552(-) A/G INTRON_VARIANT
714317 Benign: not provided 90,544,640(-) AAC/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MAP3K7 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP3K7 Gene

Variant ID Type Subtype PubMed ID
esv1333350 CNV deletion 17803354
esv1987764 CNV deletion 18987734
esv2449643 CNV deletion 19546169
esv2732413 CNV deletion 23290073
esv3540130 CNV deletion 23714750
esv3668 CNV loss 18987735
esv5848 CNV loss 19470904
esv992475 CNV deletion 20482838
nsv1073998 CNV deletion 25765185
nsv1114854 CNV deletion 24896259
nsv523939 CNV gain 19592680
nsv956539 CNV deletion 24416366

Variation tolerance for MAP3K7 Gene

Residual Variation Intolerance Score: 9.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K7 Gene

Human Gene Mutation Database (HGMD)
MAP3K7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K7 Gene

Disorders for MAP3K7 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MAP3K7 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cardiospondylocarpofacial syndrome
  • cscf
frontometaphyseal dysplasia 2
  • fmd2
frontometaphyseal dysplasia
  • fmd
herpes simplex
  • herpesvirus hominis disease
hyperostosis
  • bone hypertrophy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

M3K7_HUMAN
  • Frontometaphyseal dysplasia 2 (FMD2) [MIM:617137]: A form of frontometaphyseal dysplasia, a progressive sclerosing skeletal dysplasia affecting the long bones and skull. Characteristic features include supraorbital hyperostosis, cranial hyperostosis, undermodeling of the small bones, flared metaphyses, and digital anomalies. Extra-skeletal manifestations include hearing loss, cardiac malformations, and stenosis, particularly of the upper airway and urinary tract. FMD2 inheritance is autosomal dominant. {ECO:0000269 PubMed:27426733}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cardiospondylocarpofacial syndrome (CSCF) [MIM:157800]: A syndrome characterized by growth retardation, dysmorphic facial features, brachydactyly with carpal-tarsal fusion and extensive posterior cervical vertebral synostosis, cardiac septal defects with valve dysplasia, and deafness with inner ear malformations. CSCF transmission pattern is consistent with autosomal dominant inheritance. {ECO:0000269 PubMed:27426734}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MAP3K7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAP3K7: view

No data available for Genatlas for MAP3K7 Gene

Publications for MAP3K7 Gene

  1. Direct activation of protein kinases by unanchored polyubiquitin chains. (PMID: 19675569) Xia ZP … Chen ZJ (Nature 2009) 3 4 23
  2. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PMID: 18286207) Blanco S … Lazo PA (PloS one 2008) 3 4 23
  3. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PMID: 18758450) Sorrentino A … Landström M (Nature cell biology 2008) 3 4 23
  4. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PMID: 16845370) Thiefes A … Kracht M (EMBO reports 2006) 3 4 23
  5. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PMID: 16893890) Huangfu WC … Ninomiya-Tsuji J (The Journal of biological chemistry 2006) 3 4 23

ExternalLinks

View latest publications for MAP3K7 gene in Mastermind

Products for MAP3K7 Gene