Aliases for TAF10 Gene
- TATA-Box Binding Protein Associated Factor 10 2 3 5
- TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa 2 3
- TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, H, 30kD 2 3
- Transcription Initiation Factor TFIID 30 KDa Subunit 3 4
- TAF(II)30 3 4
- TAFII-30 3 4
- TAFII30 3 4
External Ids for TAF10 Gene
Previous HGNC Symbols for TAF10 Gene
Previous GeneCards Identifiers for TAF10 Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAF10 Gene
TAF10 (TATA-Box Binding Protein Associated Factor 10) is a Protein Coding gene. Diseases associated with TAF10 include Neuronal Ceroid Lipofuscinosis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity.
UniProtKB/Swiss-Prot for TAF10 Gene
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.