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Aliases for TAGLN Gene

Aliases for TAGLN Gene

  • Transgelin 2 3 3 5
  • SM22-Alpha 2 3 4
  • Smooth Muscle Protein 22-Alpha 3 4
  • 22 KDa Actin-Binding Protein 3 4
  • Transgelin Variant 2 2 3
  • WS3-10 3 4
  • SM22 3 4
  • Protein WS3-10 4
  • TAGLN1 3
  • SMCC 3

External Ids for TAGLN Gene

Previous GeneCards Identifiers for TAGLN Gene

  • GC11P119422
  • GC11P118581
  • GC11P117103
  • GC11P116607
  • GC11P116575
  • GC11P117070
  • GC11P113002

Summaries for TAGLN Gene

Entrez Gene Summary for TAGLN Gene

  • This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]

GeneCards Summary for TAGLN Gene

TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include Laryngeal Small Cell Carcinoma and Gastric Small Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TAGLN3.

UniProtKB/Swiss-Prot for TAGLN Gene

  • Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.

Gene Wiki entry for TAGLN Gene

Additional gene information for TAGLN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN Gene

Genomics for TAGLN Gene

GeneHancer (GH) Regulatory Elements for TAGLN Gene

Promoters and enhancers for TAGLN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J117197 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.5 2494 9.3 BCOR CTCF KLF1 ZBTB6 SIN3A ZMYM3 KLF14 ZIC2 ZBTB40 RAD21 LOC100652768 TAGLN LOC653303 PCSK7 APOA1 RNF214 SIDT2 ENSG00000280143
GH11J116825 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -365.9 -365915 16.6 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF2 IRF4 YY1 SLC30A9 APOA1 APOC3 GC11P116833 GC11P116832 APOA5 LOC653303 BUD13 TAGLN ZPR1 ENSG00000226645
GH11J117173 Enhancer 0.7 ENCODE dbSUPER 37.7 -24.5 -24452 1.8 JUND ZNF362 EGR1 ZSCAN4 ZNF7 TAGLN LOC653303 PAFAH1B2 ENSG00000254678 RNF214 PCSK7 ZPR1 APOA5 SIDT2
GH11J117070 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.8 -126.6 -126620 3.6 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B FEZF1 YY1 ZNF766 FOS GC11M117070 SIK3 LOC653303 ENSG00000224077 TAGLN APOA1
GH11J116978 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -218.5 -218477 4 CEBPB MAX ELF1 DPF2 NBN ATF7 ETV6 MLLT1 RUNX3 IKZF2 LOC653303 SIK3 APOA1 ENSG00000224077 TAGLN GC11P117017
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAGLN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAGLN gene promoter:
  • Sp1
  • Nkx2-5

Genomic Locations for TAGLN Gene

Genomic Locations for TAGLN Gene
5,472 bases
Plus strand
5,472 bases
Plus strand

Genomic View for TAGLN Gene

Genes around TAGLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN Gene

Proteins for TAGLN Gene

  • Protein details for TAGLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O15542

    Protein attributes for TAGLN Gene

    201 amino acids
    Molecular mass:
    22611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAGLN Gene

Post-translational modifications for TAGLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAGLN Gene

Domains & Families for TAGLN Gene

Gene Families for TAGLN Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calponin family.
  • Belongs to the calponin family.
genes like me logo Genes that share domains with TAGLN: view

Function for TAGLN Gene

Molecular function for TAGLN Gene

UniProtKB/Swiss-Prot Function:
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
UniProtKB/Swiss-Prot Induction:
Overexpressed in senescent human fibroblasts.
GENATLAS Biochemistry:
transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine Sm22 alpha homolog,highly expressed in senescent fibroblasts and in fibroblasts from patients with Werner syndrome

Phenotypes From GWAS Catalog for TAGLN Gene

Gene Ontology (GO) - Molecular Function for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 21044950
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TAGLN: view
genes like me logo Genes that share phenotypes with TAGLN: view

Animal Models for TAGLN Gene

MGI Knock Outs for TAGLN:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGLN Gene

Localization for TAGLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAGLN Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGLN gene
Compartment Confidence
cytosol 4
cytoskeleton 3
extracellular 2
nucleus 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAGLN: view

Pathways & Interactions for TAGLN Gene

SuperPathways for TAGLN Gene

No Data Available

SIGNOR curated interactions for TAGLN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development TAS 9615232
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TAGLN: view

No data available for Pathways by source for TAGLN Gene

Drugs & Compounds for TAGLN Gene

(6) Drugs for TAGLN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(6) Additional Compounds for TAGLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAGLN: view

Transcripts for TAGLN Gene

mRNA/cDNA for TAGLN Gene

Unigene Clusters for TAGLN Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - - - - - - -
SP9: - - - -

Relevant External Links for TAGLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAGLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAGLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN Gene

This gene is overexpressed in Artery - Tibial (x6.0), Artery - Coronary (x5.5), Artery - Aorta (x5.1), Esophagus - Muscularis (x4.4), and Colon - Sigmoid (x4.4).

Protein differential expression in normal tissues from HIPED for TAGLN Gene

This gene is overexpressed in Seminal vesicle (10.8), Cardia (10.3), Colon muscle (7.6), and Prostate (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAGLN Gene

Protein tissue co-expression partners for TAGLN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAGLN Gene:


SOURCE GeneReport for Unigene cluster for TAGLN Gene:


Evidence on tissue expression from TISSUES for TAGLN Gene

  • Liver(4.5)
  • Lung(4.5)
  • Nervous system(4.5)
  • Intestine(4.4)
  • Blood(4.3)
  • Muscle(4)
  • Eye(3.9)
  • Pancreas(3.9)
  • Skin(3.9)
  • Bone(3.7)
  • Stomach(3.4)
  • Heart(3.3)
  • Kidney(3.1)
  • Gall bladder(2.8)
  • Lymph node(2.7)
  • Adrenal gland(2.4)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with TAGLN: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGLN Gene

Orthologs for TAGLN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAGLN 34 33
  • 99.67 (n)
(Monodelphis domestica)
Mammalia TAGLN 34
  • 97 (a)
(Bos Taurus)
Mammalia TAGLN 34 33
  • 93.7 (n)
(Canis familiaris)
Mammalia TAGLN 34 33
  • 92.7 (n)
(Rattus norvegicus)
Mammalia Tagln 33
  • 91.71 (n)
(Mus musculus)
Mammalia Tagln 16 34 33
  • 91.04 (n)
(Gallus gallus)
Aves TAGLN 34 33
  • 82.83 (n)
(Anolis carolinensis)
Reptilia TAGLN 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tagln 33
  • 73.96 (n)
Str.5784 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68550 33
(Danio rerio)
Actinopterygii tagln 34 33
  • 73.23 (n)
tagln2 34
  • 69 (a)
Dr.20602 33
fruit fly
(Drosophila melanogaster)
Insecta CG5023 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea cpn-2 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
CSA.10356 34
  • 36 (a)
-- 34
  • 34 (a)
Species where no ortholog for TAGLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN Gene

Gene Tree for TAGLN (if available)
Gene Tree for TAGLN (if available)
Evolutionary constrained regions (ECRs) for TAGLN: view image

Paralogs for TAGLN Gene

Paralogs for TAGLN Gene

(5) SIMAP similar genes for TAGLN Gene using alignment to 6 proteins:

  • B0YJ58_HUMAN
  • E9PJ32_HUMAN
  • Q5U0D2_HUMAN
  • Q6FI52_HUMAN
genes like me logo Genes that share paralogs with TAGLN: view

Variants for TAGLN Gene

Sequence variations from dbSNP and Humsavar for TAGLN Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000988515 -- 117,204,965(+) A/G downstream_transcript_variant
rs1000992923 -- 117,200,462(+) C/T intron_variant
rs1002998544 -- 117,198,526(+) A/G upstream_transcript_variant
rs1003024284 -- 117,201,730(+) C/T intron_variant
rs1003877206 -- 117,201,818(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAGLN Gene

Variant ID Type Subtype PubMed ID
dgv2186n54 CNV loss 21841781
dgv730n106 OTHER inversion 24896259
nsv1078301 OTHER inversion 25765185
nsv524270 CNV loss 19592680
nsv7223 OTHER inversion 18451855

Variation tolerance for TAGLN Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAGLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN Gene

Disorders for TAGLN Gene

MalaCards: The human disease database

(6) MalaCards diseases for TAGLN Gene - From: DISEASES

Disorder Aliases PubMed IDs
laryngeal small cell carcinoma
  • small cell carcinoma of larynx
gastric small cell carcinoma
  • small cell carcinoma of stomach
small cell cancer of the lung
  • sclc1
cervix small cell carcinoma
  • small cell carcinoma of the cervix
retinitis pigmentosa 26
  • rp26
- elite association - COSMIC cancer census association via MalaCards
Search TAGLN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAGLN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TAGLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAGLN Gene

Publications for TAGLN Gene

  1. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PMID: 1520290) Thweatt R … Goldstein S (Biochemical and biophysical research communications 1992) 2 3 4 22 58
  2. Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array. (PMID: 20066125) Nakai K … Ogawa A (Bioinformatics and biology insights 2009) 3 22 44 58
  3. Expression and cytogenetic localization of the human SM22 gene (TAGLN). (PMID: 9615232) Camoretti-Mercado B … Solway J (Genomics 1998) 3 4 22 58
  4. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PMID: 21943158) Middelberg RP … Whitfield JB (BMC medical genetics 2011) 3 44 58
  5. Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53. (PMID: 20098441) Zhang ZW … Chen ZD (Asian journal of andrology 2010) 3 22 58

Products for TAGLN Gene

Sources for TAGLN Gene

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