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Aliases for TAF4 Gene

Aliases for TAF4 Gene

  • TATA-Box Binding Protein Associated Factor 4 2 3 5
  • TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C1, 130kD 2 3
  • Transcription Initiation Factor TFIID 130 KDa Subunit 3 4
  • Transcription Initiation Factor TFIID 135 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit C 3 4
  • TBP-Associated Factor 4 3 4
  • TAF(II)130 3 4
  • TAF(II)135 3 4
  • TAFII-130 3 4
  • TAFII-135 3 4
  • TAFII130 3 4
  • TAFII135 3 4
  • TAF2C1 3 4
  • TAF2C 3 4
  • TAF4A 3 4
  • TAF4A RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135 KD 3
  • Transcription Initiation Factor TFIID 135 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 4 3

External Ids for TAF4 Gene

Previous HGNC Symbols for TAF4 Gene

  • TAF4A
  • TAF2C1
  • TAF2C

Previous GeneCards Identifiers for TAF4 Gene

  • GC20M060313
  • GC20M061166
  • GC20M061235
  • GC20M059983
  • GC20M060529
  • GC20M057327

Summaries for TAF4 Gene

Entrez Gene Summary for TAF4 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF4 Gene

TAF4 (TATA-Box Binding Protein Associated Factor 4) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is TAF4B.

UniProtKB/Swiss-Prot for TAF4 Gene

  • Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

Gene Wiki entry for TAF4 Gene

Additional gene information for TAF4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF4 Gene

Genomics for TAF4 Gene

GeneHancer (GH) Regulatory Elements for TAF4 Gene

Promoters and enhancers for TAF4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I062063 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.1 -109 5.1 PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B LOC105372705 MIR3195 TAF4
GH20I062300 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 59.9 -238.0 -237980 5.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ADRM1 DIDO1 TAF4 MRGBP ENSG00000226332 RPS21 LAMA5 GID8 LAMA5-AS1 CABLES2
GH20I062500 Enhancer 1.6 FANTOM5 Ensembl ENCODE 54.4 -435.8 -435813 2.8 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A YBX1 ZNF2 ZBTB7B DIDO1 TAF4 LAMA5 ENSG00000226332 MRGBP RPS21 HAR1A MTG2 YTHDF1 DPH3P1
GH20I062385 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.4 -321.5 -321516 3.9 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 RPS21 ENSG00000273619 DIDO1 TAF4 CABLES2 ENSG00000226332 LAMA5 LSM14B GID8 OSBPL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAF4 gene promoter:

Genomic Locations for TAF4 Gene

Genomic Locations for TAF4 Gene
112,342 bases
Minus strand

Genomic View for TAF4 Gene

Genes around TAF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF4 Gene

Proteins for TAF4 Gene

  • Protein details for TAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription initiation factor TFIID subunit 4
    Protein Accession:
    Secondary Accessions:
    • A6NGD9
    • Q5TBP6
    • Q99721
    • Q9BR40
    • Q9BX42

    Protein attributes for TAF4 Gene

    1085 amino acids
    Molecular mass:
    110114 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts with SV40 Large T antigen.

    Three dimensional structures from OCA and Proteopedia for TAF4 Gene

neXtProt entry for TAF4 Gene

Post-translational modifications for TAF4 Gene

  • Ubiquitination at isoforms=611
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF4 Gene

Domains & Families for TAF4 Gene

Gene Families for TAF4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TAF4 family.
  • Belongs to the TAF4 family.
genes like me logo Genes that share domains with TAF4: view

Function for TAF4 Gene

Molecular function for TAF4 Gene

UniProtKB/Swiss-Prot Function:
Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

Phenotypes From GWAS Catalog for TAF4 Gene

Gene Ontology (GO) - Molecular Function for TAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001075 contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA --
GO:0003677 DNA binding IDA,IEA 15601843
GO:0003700 contributes_to DNA binding transcription factor activity IDA,IEA 9603525
GO:0003713 transcription coactivator activity TAS 9192867
GO:0005515 protein binding IPI 7729427
genes like me logo Genes that share ontologies with TAF4: view
genes like me logo Genes that share phenotypes with TAF4: view

Animal Models for TAF4 Gene

MGI Knock Outs for TAF4:

miRNA for TAF4 Gene

Clone Products

  • Addgene plasmids for TAF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF4 Gene

Localization for TAF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF4 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 24289924
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA,IEA 14580349
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TAF4: view

Pathways & Interactions for TAF4 Gene

genes like me logo Genes that share pathways with TAF4: view

Gene Ontology (GO) - Biological Process for TAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IDA,IEA 9603525
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with TAF4: view

No data available for SIGNOR curated interactions for TAF4 Gene

Drugs & Compounds for TAF4 Gene

(1) Drugs for TAF4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cholecalciferol Approved Nutra Fat-soluble secosteroids 922,916
genes like me logo Genes that share compounds with TAF4: view

Transcripts for TAF4 Gene

Unigene Clusters for TAF4 Gene

TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa:
Representative Sequences:

Clone Products

  • Addgene plasmids for TAF4

Alternative Splicing Database (ASD) splice patterns (SP) for TAF4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: - - - - -
SP2: - -

Relevant External Links for TAF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF4 Gene

Protein differential expression in normal tissues from HIPED for TAF4 Gene

This gene is overexpressed in Liver (28.9) and Pancreatic juice (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF4 Gene

Protein tissue co-expression partners for TAF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF4 Gene:


SOURCE GeneReport for Unigene cluster for TAF4 Gene:

genes like me logo Genes that share expression patterns with TAF4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF4 Gene

Orthologs for TAF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAF4 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia TAF4 33 34
  • 89.25 (n)
(Bos Taurus)
Mammalia TAF4 33 34
  • 88.6 (n)
(Mus musculus)
Mammalia Taf4a 33 34
  • 83.74 (n)
Taf4 16
(Ornithorhynchus anatinus)
Mammalia TAF4 34
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
-- 34
  • 62 (a)
(Gallus gallus)
Aves TAF4 33 34
  • 77.51 (n)
(Anolis carolinensis)
Reptilia TAF4 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia taf4 33
  • 73.59 (n)
Str.19609 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.34362 33
(Danio rerio)
Actinopterygii TAF4 (1 of 2) 34
  • 74 (a)
LOC100149942 33
  • 63.99 (n)
TAF4 (2 of 2) 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taf4 35 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea taf-4 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8870 34
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2415 33
Species where no ortholog for TAF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF4 Gene

Gene Tree for TAF4 (if available)
Gene Tree for TAF4 (if available)

Paralogs for TAF4 Gene

Paralogs for TAF4 Gene

(2) SIMAP similar genes for TAF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAF4: view

Variants for TAF4 Gene

Sequence variations from dbSNP and Humsavar for TAF4 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000003021 -- 61,998,821(-) A/T intron_variant
rs1000061128 -- 62,064,405(-) C/T intron_variant
rs1000062720 -- 62,039,670(-) T/C intron_variant
rs1000067117 -- 62,014,446(-) C/T intron_variant
rs1000071229 -- 61,979,912(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAF4 Gene

Variant ID Type Subtype PubMed ID
dgv2280n106 CNV deletion 24896259
dgv2281n106 CNV deletion 24896259
dgv665e201 CNV deletion 23290073
dgv666e201 CNV deletion 23290073
dgv7644n54 CNV loss 21841781
dgv7645n54 CNV gain 21841781
dgv7646n54 CNV gain+loss 21841781
dgv7647n54 CNV loss 21841781
esv1495793 CNV insertion 17803354
esv1507005 CNV insertion 17803354
esv1640297 CNV deletion 17803354
esv1724276 CNV insertion 17803354
esv23198 CNV loss 19812545
esv2375011 CNV deletion 18987734
esv25248 CNV gain+loss 19812545
esv2550695 CNV deletion 19546169
esv2564070 CNV deletion 19546169
esv2645658 CNV insertion 19546169
esv2662438 CNV deletion 23128226
esv2722759 CNV deletion 23290073
esv2722760 CNV deletion 23290073
esv2722762 CNV deletion 23290073
esv2722763 CNV deletion 23290073
esv2722764 CNV deletion 23290073
esv2722766 CNV deletion 23290073
esv2722770 CNV deletion 23290073
esv2722773 CNV deletion 23290073
esv2722774 CNV deletion 23290073
esv2722775 CNV deletion 23290073
esv2722776 CNV deletion 23290073
esv2758804 CNV gain+loss 17122850
esv3557324 CNV deletion 23714750
esv3557325 CNV deletion 23714750
esv3568094 CNV loss 25503493
esv4304 CNV loss 18987735
esv8279 CNV loss 19470904
esv999370 CNV insertion 20482838
nsv1071707 CNV deletion 25765185
nsv1072129 CNV deletion 25765185
nsv1073077 CNV deletion 25765185
nsv1132900 CNV insertion 24896259
nsv1136560 CNV deletion 24896259
nsv1141798 CNV insertion 24896259
nsv1142487 CNV deletion 24896259
nsv1142994 CNV tandem duplication 24896259
nsv179612 CNV deletion 16902084
nsv428378 CNV loss 18775914
nsv472004 CNV novel sequence insertion 20440878
nsv473877 CNV novel sequence insertion 20440878
nsv479317 CNV novel sequence insertion 20440878
nsv509781 CNV insertion 20534489
nsv512623 CNV loss 21212237
nsv586472 CNV loss 21841781
nsv586474 CNV loss 21841781
nsv821030 CNV deletion 20802225
nsv828768 CNV gain 20364138
nsv828769 CNV gain 20364138
nsv955146 CNV deletion 24416366
nsv955147 CNV deletion 24416366
nsv955148 CNV deletion 24416366
nsv956198 CNV deletion 24416366

Variation tolerance for TAF4 Gene

Residual Variation Intolerance Score: 5.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF4 Gene

Disorders for TAF4 Gene

Additional Disease Information for TAF4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TAF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF4 Gene

Publications for TAF4 Gene

  1. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PMID: 10594036) Gangloff YG … Davidson I (Molecular and cellular biology 2000) 3 4 22 58
  2. Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. (PMID: 9192867) Mengus G … Davidson I (Genes & development 1997) 2 3 4 58
  3. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PMID: 8942982) Tanese N … Admon A (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 58
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58

Products for TAF4 Gene

  • Addgene plasmids for TAF4

Sources for TAF4 Gene

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