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Aliases for TACC1 Gene

Aliases for TACC1 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 1 2 3 5
  • Gastric Cancer Antigen Ga55 3 4
  • Taxin-1 3 4
  • Transforming, Acidic Coiled-Coil Containing Protein 1 2
  • Transforming Acidic Coiled-Coil-Containing Protein 1 3
  • KIAA1103 4
  • Ga55 3

External Ids for TACC1 Gene

Previous GeneCards Identifiers for TACC1 Gene

  • GC08P038196
  • GC08P038859
  • GC08P038326
  • GC08P038603
  • GC08P038733
  • GC08P038586
  • GC08P037121

Summaries for TACC1 Gene

Entrez Gene Summary for TACC1 Gene

  • This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

GeneCards Summary for TACC1 Gene

TACC1 (Transforming Acidic Coiled-Coil Containing Protein 1) is a Protein Coding gene. Diseases associated with TACC1 include Gliosarcoma and Giant Cell Glioblastoma. Among its related pathways are Aurora B signaling and Aurora A signaling. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot for TACC1 Gene

  • Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Gene Wiki entry for TACC1 Gene

Additional gene information for TACC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC1 Gene

Genomics for TACC1 Gene

GeneHancer (GH) Regulatory Elements for TACC1 Gene

Promoters and enhancers for TACC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I038784 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 575.2 +61.4 61422 10.1 HDGF PKNOX1 FOXA2 SMAD1 ARNT NEUROD1 SIN3A FEZF1 YY1 POLR2B TACC1 ASH2L LETM2 PLEKHA2 ENSG00000253586 ENSG00000207258
GH08I038727 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 556.1 +1.0 1024 4.3 TFAP4 TAF1 MAX NR2F2 YY1 ATF3 HNF4A EZH2 TACC1 ENSG00000207258 GC08P038745
GH08I038764 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 30.2 +40.2 40210 7.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A YBX1 ZNF2 IRF4 YY1 DDHD2 NSD3 TACC1 ENSG00000255201 ADGRA2 FGFR1 TM2D2 LETM2 EIF4EBP1 RPS20P22
GH08I038934 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +209.4 209386 6.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 ZNF766 ZNF207 TACC1 PLEKHA2 ENSG00000253645 GC08M038869
GH08I038379 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8 -344.7 -344654 8.1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 NFYC NSD3 LETM2 ENSG00000272092 DDHD2 RPS20P22 ERLIN2 ASH2L TM2D2 ENSG00000255201 LOC102723716
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TACC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TACC1 gene promoter:

Genomic Locations for TACC1 Gene

Genomic Locations for TACC1 Gene
chr8:38,728,186-38,853,028
(GRCh38/hg38)
Size:
124,843 bases
Orientation:
Plus strand
chr8:38,585,704-38,710,546
(GRCh37/hg19)

Genomic View for TACC1 Gene

Genes around TACC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC1 Gene

Proteins for TACC1 Gene

  • Protein details for TACC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75410-TACC1_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 1
    Protein Accession:
    O75410
    Secondary Accessions:
    • B2RBD9
    • D3DSX6
    • Q6Y687
    • Q86YG7
    • Q8IUJ2
    • Q8IUJ3
    • Q8IUJ4
    • Q8IZG2
    • Q8NEY7
    • Q9UPP9

    Protein attributes for TACC1 Gene

    Size:
    805 amino acids
    Molecular mass:
    87794 Da
    Quaternary structure:
    • Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.

    Alternative splice isoforms for TACC1 Gene

neXtProt entry for TACC1 Gene

Post-translational modifications for TACC1 Gene

No data available for DME Specific Peptides for TACC1 Gene

Domains & Families for TACC1 Gene

Gene Families for TACC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TACC1 Gene

Graphical View of Domain Structure for InterPro Entry

O75410

UniProtKB/Swiss-Prot:

TACC1_HUMAN :
  • Belongs to the TACC family.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC1: view

Function for TACC1 Gene

Molecular function for TACC1 Gene

GENATLAS Biochemistry:
transforming acidic coiled-coil gene 1,highly expressed during early embryogenesis,potentially promoting tumorigenicity in breast cancers with amplification of the 8p11 region
UniProtKB/Swiss-Prot Function:
Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Phenotypes From GWAS Catalog for TACC1 Gene

Gene Ontology (GO) - Molecular Function for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11903063
genes like me logo Genes that share ontologies with TACC1: view
genes like me logo Genes that share phenotypes with TACC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TACC1 Gene

Localization for TACC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. {ECO:0000269 PubMed:21531210}.
Isoform 5: Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACC1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 4

Gene Ontology (GO) - Cellular Components for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0015630 microtubule cytoskeleton IBA --
genes like me logo Genes that share ontologies with TACC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TACC1 Gene

Pathways & Interactions for TACC1 Gene

genes like me logo Genes that share pathways with TACC1: view

Pathways by source for TACC1 Gene

2 BioSystems pathways for TACC1 Gene

Gene Ontology (GO) - Biological Process for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation IBA --
GO:0021987 cerebral cortex development IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with TACC1: view

No data available for SIGNOR curated interactions for TACC1 Gene

Drugs & Compounds for TACC1 Gene

No Compound Related Data Available

Transcripts for TACC1 Gene

Unigene Clusters for TACC1 Gene

Transforming, acidic coiled-coil containing protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - -
SP12: - - -
SP13: - -
SP14:
SP15:
SP16:

ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TACC1 Gene

GeneLoc Exon Structure for
TACC1
ECgene alternative splicing isoforms for
TACC1

Expression for TACC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TACC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TACC1 Gene

This gene is overexpressed in Liver (20.7) and Peripheral blood mononuclear cells (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TACC1 Gene



Protein tissue co-expression partners for TACC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TACC1 Gene:

TACC1

SOURCE GeneReport for Unigene cluster for TACC1 Gene:

Hs.279245

mRNA Expression by UniProt/SwissProt for TACC1 Gene:

O75410-TACC1_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.

Evidence on tissue expression from TISSUES for TACC1 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Muscle(4.3)
  • Lung(2.7)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with TACC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACC1 Gene

Orthologs for TACC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACC1 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia TACC1 33 34
  • 87.62 (n)
rat
(Rattus norvegicus)
Mammalia Tacc1 33
  • 80.34 (n)
mouse
(Mus musculus)
Mammalia Tacc1 33 16 34
  • 80.16 (n)
cow
(Bos Taurus)
Mammalia TACC1 33 34
  • 79.96 (n)
oppossum
(Monodelphis domestica)
Mammalia TACC1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACC1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACC1 33 34
  • 69.05 (n)
lizard
(Anolis carolinensis)
Reptilia TACC1 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacc1 33
  • 65.44 (n)
Str.5836 33
zebrafish
(Danio rerio)
Actinopterygii tacc1 33 34
  • 57.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta tacc 34
  • 10 (a)
OneToMany
Species where no ortholog for TACC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC1 Gene

ENSEMBL:
Gene Tree for TACC1 (if available)
TreeFam:
Gene Tree for TACC1 (if available)

Paralogs for TACC1 Gene

Paralogs for TACC1 Gene

Pseudogenes.org Pseudogenes for TACC1 Gene

genes like me logo Genes that share paralogs with TACC1: view

Variants for TACC1 Gene

Sequence variations from dbSNP and Humsavar for TACC1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000009853 -- 38,827,535(+) A/G intron_variant
rs1000038467 -- 38,814,995(+) A/T intron_variant
rs1000074338 -- 38,783,583(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000101274 -- 38,792,945(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000105375 -- 38,763,452(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TACC1 Gene

Variant ID Type Subtype PubMed ID
esv25816 CNV loss 19812545
esv3433731 CNV duplication 20981092
esv3449093 CNV insertion 20981092
esv3616933 CNV loss 21293372
nsv396891 CNV insertion 16902084
nsv528721 CNV loss 19592680
nsv831296 CNV gain 17160897

Variation tolerance for TACC1 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC1 Gene

Disorders for TACC1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TACC1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
giant cell glioblastoma
  • monstrocellular sarcoma [obs]
gastric cancer
  • gastric cancer, somatic
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search TACC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TACC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TACC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACC1 Gene

Publications for TACC1 Gene

  1. Aurora B -TACC1 protein complex in cytokinesis. (PMID: 15064709) Delaval B … Birnbaum D (Oncogene 2004) 3 4 22 58
  2. TACC1-chTOG-Aurora A protein complex in breast cancer. (PMID: 14603251) Conte N … Birnbaum D (Oncogene 2003) 3 4 22 58
  3. Altered splicing pattern of TACC1 mRNA in gastric cancer. (PMID: 12547166) Line A … Rees RC (Cancer genetics and cytogenetics 2002) 3 4 22 58
  4. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N … Birnbaum D (Oncogene 2002) 3 4 22 58
  5. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PMID: 11903063) Lauffart B … Still IH (The Biochemical journal 2002) 3 4 22 58

Products for TACC1 Gene

Sources for TACC1 Gene

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