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Aliases for SYPL1 Gene

Aliases for SYPL1 Gene

  • Synaptophysin Like 1 2 3 5
  • Pantophysin 2 3 4
  • SYPL 3 4
  • Synaptophysin-Like Protein 1 3
  • Synaptophysin-Like Protein 2
  • Synaptophysin-Like 1 2
  • H-SP1 3

External Ids for SYPL1 Gene

Previous HGNC Symbols for SYPL1 Gene

  • SYPL

Previous GeneCards Identifiers for SYPL1 Gene

  • GC07M105325
  • GC07M105518
  • GC07M105730
  • GC07M100090

Summaries for SYPL1 Gene

GeneCards Summary for SYPL1 Gene

SYPL1 (Synaptophysin Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SYNPR.

Gene Wiki entry for SYPL1 Gene

Additional gene information for SYPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYPL1 Gene

Genomics for SYPL1 Gene

GeneHancer (GH) Regulatory Elements for SYPL1 Gene

Promoters and enhancers for SYPL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J106108 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 656.1 +1.5 1516 4.9 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 SYPL1 ATXN7L1 DCAF13P1 GC07M106082
GH07J106056 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +50.8 50836 10.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 IRF4 YY1 CBX5 SYPL1 GC07M106081 GC07P106037
GH07J106068 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13 +41.0 41005 6.9 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A YBX1 FEZF1 ATXN7L1 SYPL1 DCAF13P1 GC07M106081 GC07P106037
GH07J106050 Enhancer 0.9 ENCODE dbSUPER 16.7 +62.0 61986 1.1 SOX13 CTCF TFAP4 ARID4B ERF CEBPG ZNF644 RAD21 TEAD3 CTBP1 SYPL1 GC07P106037 GC07M106081
GH07J106153 Enhancer 1 Ensembl ENCODE 12.8 -41.3 -41291 0.7 RB1 BMI1 ZNF2 RAD21 ARID2 ZNF143 RCOR1 RUNX3 SMARCA5 ZNF654 SYPL1 GC07P106126 GC07P106209
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYPL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYPL1 gene promoter:
  • Nkx3-1 v2
  • STAT5A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for SYPL1 Gene

Genomic Locations for SYPL1 Gene
22,280 bases
Minus strand
22,109 bases
Minus strand

Genomic View for SYPL1 Gene

Genes around SYPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYPL1 Gene

Proteins for SYPL1 Gene

  • Protein details for SYPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptophysin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A4D0R2
    • Q96AR8

    Protein attributes for SYPL1 Gene

    259 amino acids
    Molecular mass:
    28565 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYPL1 Gene


neXtProt entry for SYPL1 Gene

Post-translational modifications for SYPL1 Gene

  • Glycosylation at posLast=212212 and isoforms=271
  • Modification sites at PhosphoSitePlus

Other Protein References for SYPL1 Gene

Antibody Products

  • Abcam antibodies for SYPL1
  • Boster Bio Antibodies for SYPL1

No data available for DME Specific Peptides for SYPL1 Gene

Domains & Families for SYPL1 Gene

Gene Families for SYPL1 Gene

Protein Domains for SYPL1 Gene


Suggested Antigen Peptide Sequences for SYPL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptophysin/synaptobrevin family.
  • Belongs to the synaptophysin/synaptobrevin family.
genes like me logo Genes that share domains with SYPL1: view

Function for SYPL1 Gene

genes like me logo Genes that share phenotypes with SYPL1: view

Animal Models for SYPL1 Gene

MGI Knock Outs for SYPL1:
  • Sypl Sypl<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for SYPL1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYPL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYPL1 Gene

Localization for SYPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYPL1 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYPL1 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8034131
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 1730063
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with SYPL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SYPL1 Gene

Pathways & Interactions for SYPL1 Gene

SuperPathways for SYPL1 Gene

No Data Available

Interacting Proteins for SYPL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q16563-SYPL1_HUMAN ENSP00000011473 for SYPL1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission TAS 8034131
genes like me logo Genes that share ontologies with SYPL1: view

No data available for Pathways by source and SIGNOR curated interactions for SYPL1 Gene

Drugs & Compounds for SYPL1 Gene

No Compound Related Data Available

Transcripts for SYPL1 Gene

mRNA/cDNA for SYPL1 Gene

Unigene Clusters for SYPL1 Gene

Synaptophysin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYPL1

Alternative Splicing Database (ASD) splice patterns (SP) for SYPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -
SP8: -

Relevant External Links for SYPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SYPL1 Gene

This gene is overexpressed in Nasal epithelium (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYPL1 Gene

Protein tissue co-expression partners for SYPL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYPL1 Gene:


SOURCE GeneReport for Unigene cluster for SYPL1 Gene:


Evidence on tissue expression from TISSUES for SYPL1 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Liver(4.4)
  • Skin(4.3)
  • Blood(4.1)
  • Kidney(3.8)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with SYPL1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYPL1 Gene

Orthologs for SYPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYPL1 34 33
  • 99.45 (n)
(Canis familiaris)
Mammalia SYPL1 34 33
  • 87.58 (n)
(Rattus norvegicus)
Mammalia Sypl1 33
  • 85.14 (n)
(Mus musculus)
Mammalia Sypl 16 34 33
  • 83.91 (n)
(Bos Taurus)
Mammalia SYPL1 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SYPL1 34
  • 68 (a)
(Monodelphis domestica)
Mammalia SYPL1 34
  • 63 (a)
(Gallus gallus)
Aves SYPL1 34 33
  • 68.19 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 58 (a)
-- 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sypl1 33
  • 63.32 (n)
MGC76143 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398646 33
(Danio rerio)
Actinopterygii LOC100330238 33
  • 54.04 (n)
sypl1 34
  • 46 (a)
(Caenorhabditis elegans)
Secernentea sph-1 34
  • 26 (a)
Species where no ortholog for SYPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYPL1 Gene

Gene Tree for SYPL1 (if available)
Gene Tree for SYPL1 (if available)
Evolutionary constrained regions (ECRs) for SYPL1: view image

Paralogs for SYPL1 Gene

Paralogs for SYPL1 Gene

(10) SIMAP similar genes for SYPL1 Gene using alignment to 3 proteins:

  • H7C4J8_HUMAN Pseudogenes for SYPL1 Gene

genes like me logo Genes that share paralogs with SYPL1: view

Variants for SYPL1 Gene

Sequence variations from dbSNP and Humsavar for SYPL1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000016267 -- 106,094,508(-) C/T intron_variant
rs1000316860 -- 106,096,924(-) AAAAAAA/AAAAAAAA intron_variant
rs1000450440 -- 106,089,883(-) C/T downstream_transcript_variant
rs1000618625 -- 106,095,645(-) C/A/T intron_variant
rs1000691068 -- 106,096,079(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYPL1 Gene

Variant ID Type Subtype PubMed ID
dgv3639n106 CNV deletion 24896259
esv2734977 CNV deletion 23290073
esv2734978 CNV deletion 23290073
esv3277051 CNV deletion 24192839
esv3542231 CNV deletion 23714750
esv3614438 CNV loss 21293372
esv4398 CNV loss 18987735
esv6202 CNV loss 19470904
nsv1027213 CNV gain 25217958
nsv1075988 CNV deletion 25765185
nsv1145958 CNV deletion 26484159
nsv365599 CNV deletion 16902084
nsv520366 CNV loss 19592680

Variation tolerance for SYPL1 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYPL1 Gene

Disorders for SYPL1 Gene

Additional Disease Information for SYPL1

No disorders were found for SYPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYPL1 Gene

Publications for SYPL1 Gene

  1. Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human. (PMID: 8034131) Leube RE (Differentiation; research in biological diversity 1994) 3 4 22 58
  2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for SYPL1 Gene

Sources for SYPL1 Gene

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