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Aliases for SURF6 Gene

Aliases for SURF6 Gene

  • Surfeit 6 2 3 5
  • Surfeit Locus Protein 6 2 3
  • SURF-6 4
  • RRP14 3

External Ids for SURF6 Gene

Previous GeneCards Identifiers for SURF6 Gene

  • GC09M127287
  • GC09M127754
  • GC09M129551
  • GC09M131473
  • GC09M133227
  • GC09M135187
  • GC09M136197
  • GC09M105697

Summaries for SURF6 Gene

Entrez Gene Summary for SURF6 Gene

  • This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SURF6 Gene

SURF6 (Surfeit 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for SURF6 Gene

  • Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).

Gene Wiki entry for SURF6 Gene

Additional gene information for SURF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SURF6 Gene

Genomics for SURF6 Gene

GeneHancer (GH) Regulatory Elements for SURF6 Gene

Promoters and enhancers for SURF6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J133333 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 697.8 +1.1 1115 4.2 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SURF6 GTF3C5 TSC1 WDR5 BRD3 DDX31 GTF3C4 TTF1 LOC100130548 SETX
GH09J133339 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 655.3 -4.8 -4785 4 CTCF KLF17 MAX ZIC2 GABPA POLR2A ZNF143 MYC SPI1 SURF6 SURF1 ADAMTS13 ENSG00000230064 RPL21P81 MED22
GH09J133344 Promoter 0.5 EPDnew 650.4 -7.9 -7852 0.1 SURF6 MED22 ENSG00000230064
GH09J133373 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 41.9 -39.1 -39074 3.1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS DEK STKLD1 SURF4 SURF6 GTF3C5 SURF1 LOC100130548 TSC1 WDR5 TTF1 BRD3
GH09J133355 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34 -20.1 -20129 2.3 HDGF PKNOX1 ATF1 SIN3A GLI4 ZNF2 ZBTB7B BRCA1 YY1 ETS1 SURF1 SURF2 MED22 SURF6 GC09P133444 SNORD36C PIR45308
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SURF6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SURF6 gene promoter:
  • Sox9
  • ER-alpha
  • HTF
  • FOXL1
  • Pax-2
  • Pax-2a
  • Pax-2b
  • PPAR-gamma2
  • PPAR-gamma1
  • Chx10

Genomic Locations for SURF6 Gene

Genomic Locations for SURF6 Gene
7,625 bases
Minus strand
5,684 bases
Minus strand

Genomic View for SURF6 Gene

Genes around SURF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SURF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SURF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SURF6 Gene

Proteins for SURF6 Gene

  • Protein details for SURF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Surfeit locus protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T8U1
    • Q9BRK9
    • Q9BTZ5
    • Q9UK24

    Protein attributes for SURF6 Gene

    361 amino acids
    Molecular mass:
    41450 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SURF6 Gene

Post-translational modifications for SURF6 Gene

  • Ubiquitination at isoforms=7
  • Modification sites at PhosphoSitePlus

Other Protein References for SURF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for SURF6
  • Santa Cruz Biotechnology (SCBT) Antibodies for SURF6

No data available for DME Specific Peptides for SURF6 Gene

Domains & Families for SURF6 Gene

Gene Families for SURF6 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SURF6 Gene


Suggested Antigen Peptide Sequences for SURF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SURF6 family.
  • Belongs to the SURF6 family.
genes like me logo Genes that share domains with SURF6: view

Function for SURF6 Gene

Molecular function for SURF6 Gene

UniProtKB/Swiss-Prot Function:
Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).
GENATLAS Biochemistry:
surfeit 6 protein (see SURF@),located in nucleolus,ubiquitously expressed

Phenotypes From GWAS Catalog for SURF6 Gene

Gene Ontology (GO) - Molecular Function for SURF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS,IBA --
GO:0003723 RNA binding ISS,TAS --
GO:0005515 protein binding IPI 22113938
genes like me logo Genes that share ontologies with SURF6: view
genes like me logo Genes that share phenotypes with SURF6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SURF6 Gene

Localization for SURF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SURF6 Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Granular component of the nucleolus. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SURF6 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SURF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001652 granular component ISS --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus TAS 10675619
GO:0022625 cytosolic large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with SURF6: view

Pathways & Interactions for SURF6 Gene

SuperPathways for SURF6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SURF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IEA --
GO:0042273 ribosomal large subunit biogenesis IBA --
GO:0042274 ribosomal small subunit biogenesis IBA --
genes like me logo Genes that share ontologies with SURF6: view

No data available for Pathways by source and SIGNOR curated interactions for SURF6 Gene

Drugs & Compounds for SURF6 Gene

No Compound Related Data Available

Transcripts for SURF6 Gene

mRNA/cDNA for SURF6 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(432) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SURF6 Gene

Surfeit 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SURF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4
SP2: -

Relevant External Links for SURF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SURF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SURF6 Gene

Protein differential expression in normal tissues from HIPED for SURF6 Gene

This gene is overexpressed in Lung (25.5) and Peripheral blood mononuclear cells (23.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SURF6 Gene

Protein tissue co-expression partners for SURF6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SURF6 Gene:


SOURCE GeneReport for Unigene cluster for SURF6 Gene:


Evidence on tissue expression from TISSUES for SURF6 Gene

  • Lung(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SURF6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SURF6 Gene

Orthologs for SURF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SURF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SURF6 34 33
  • 99.45 (n)
(Bos Taurus)
Mammalia SURF6 34 33
  • 79.83 (n)
(Rattus norvegicus)
Mammalia Surf6 33
  • 77.71 (n)
(Canis familiaris)
Mammalia SURF6 34 33
  • 77.65 (n)
-- 34
  • 68 (a)
(Mus musculus)
Mammalia Surf6 16 34 33
  • 77.5 (n)
(Monodelphis domestica)
Mammalia SURF6 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia SURF6 34
  • 49 (a)
(Gallus gallus)
Aves SURF6 34 33
  • 56.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia surf6 33
  • 54.53 (n)
Str.415 33
African clawed frog
(Xenopus laevis)
Amphibia surf6 33
(Danio rerio)
Actinopterygii surf6 34 33
  • 51.67 (n)
zgc64008 33
fruit fly
(Drosophila melanogaster)
Insecta Surf6 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea ZK546.14 34
  • 18 (a)
Species where no ortholog for SURF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SURF6 Gene

Gene Tree for SURF6 (if available)
Gene Tree for SURF6 (if available)
Evolutionary constrained regions (ECRs) for SURF6: view image

Paralogs for SURF6 Gene Pseudogenes for SURF6 Gene

genes like me logo Genes that share paralogs with SURF6: view

No data available for Paralogs for SURF6 Gene

Variants for SURF6 Gene

Sequence variations from dbSNP and Humsavar for SURF6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000048160 -- 133,337,531(-) T/C upstream_transcript_variant
rs1000122228 -- 133,336,305(-) G/C upstream_transcript_variant
rs1000228948 -- 133,332,522(-) C/G/T intron_variant
rs1000753728 -- 133,336,398(-) C/G upstream_transcript_variant
rs1001206222 -- 133,334,249(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SURF6 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
esv3621939 CNV loss 21293372
nsv1125319 OTHER inversion 24896259

Variation tolerance for SURF6 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.58; 91.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SURF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SURF6 Gene

Disorders for SURF6 Gene

Additional Disease Information for SURF6

No disorders were found for SURF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SURF6 Gene

Publications for SURF6 Gene

  1. Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus. (PMID: 10675619) Magoulas C … Fried M (Gene 2000) 3 4 22 58
  2. [Overexpression of the nucleolar protein SURF-6 in mouse fibroblasts NIH/3T3 leads to stabilisation of intragenic transcribed spacers of the pre-rRNA]. (PMID: 21063453) Polzikov MA … Zatsepina OV (Bioorganicheskaia khimiia 2010) 2 3 58
  3. Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. (PMID: 15629442) Polzikov M … Magoulas C (Biochemical and biophysical research communications 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. (PMID: 11891058) Angiolillo A … Pietropaolo C (Gene 2002) 3 4 58

Products for SURF6 Gene

Sources for SURF6 Gene

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