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Aliases for STX5 Gene

Aliases for STX5 Gene

  • Syntaxin 5 2 3 5
  • Syntaxin 5A 2 3
  • STX5A 3 4
  • Syntaxin-5 3
  • SED5 3

External Ids for STX5 Gene

Previous HGNC Symbols for STX5 Gene

  • STX5A

Previous GeneCards Identifiers for STX5 Gene

  • GC11M062331
  • GC11M062574
  • GC11M058904

Summaries for STX5 Gene

Entrez Gene Summary for STX5 Gene

  • This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for STX5 Gene

STX5 (Syntaxin 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX5 Gene

  • Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Gene Wiki entry for STX5 Gene

Additional gene information for STX5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX5 Gene

Genomics for STX5 Gene

GeneHancer (GH) Regulatory Elements for STX5 Gene

Promoters and enhancers for STX5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062830 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.4 -361 4.6 HDGF PKNOX1 FOXA2 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 YY1 POLR2B LOC105369332 STX5 TEX54 WDR74 SNHG1 UBXN1 NXF1 SNORD28 SLC3A2 CSKMT
GH11J062838 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 94.8 -8.8 -8755 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WDR74 RNU2-2P GC11M062842 NXF1 CSKMT INTS5 SNHG1 UBXN1 MTA2 GANAB
GH11J062852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 65 -23.7 -23746 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NXF1 SNHG1 SLC3A2 ENSG00000278527 GC11M062919 GC11M062934 GC11M062938 GC11M062939 GC11M062942 SNORD25
GH11J061960 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.7 +863.2 863167 16.4 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 FTH1 GC11M061968 GC11M061969 GC11M061970 LOC399900 NXF1 INTS5 LOC105369332 CPSF7 UBXN1
GH11J062669 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 52.8 +160.6 160602 4.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 UQCC3 LBHD1 GC11M062588 EML3 LOC105369332 MTA2 GANAB WDR74 STX5 CSKMT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STX5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STX5 gene promoter:
  • AP-1
  • ATF-2

Genomic Locations for STX5 Gene

Genomic Locations for STX5 Gene
25,232 bases
Minus strand
25,192 bases
Minus strand

Genomic View for STX5 Gene

Genes around STX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX5 Gene

Proteins for STX5 Gene

  • Protein details for STX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R8T2
    • F8W8Q9
    • Q5U0D4
    • Q7Z3T6
    • Q9BUG1

    Protein attributes for STX5 Gene

    355 amino acids
    Molecular mass:
    39673 Da
    Quaternary structure:
    • Part of a ternary complex containing STX5A, NSFL1C and VCP (By similarity). Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4 (PubMed:19536132). Interacts with GM130/GOLGA2 (By similarity). Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles (PubMed:18843296).

    Three dimensional structures from OCA and Proteopedia for STX5 Gene

    Alternative splice isoforms for STX5 Gene


neXtProt entry for STX5 Gene

Post-translational modifications for STX5 Gene

  • Ubiquitination at isoforms=2, 3, 4241, isoforms=2, 3, 4148, and isoforms=2, 3, 482
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STX5 Gene

Domains & Families for STX5 Gene

Gene Families for STX5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for STX5 Gene

Suggested Antigen Peptide Sequences for STX5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the syntaxin family.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX5: view

Function for STX5 Gene

Molecular function for STX5 Gene

UniProtKB/Swiss-Prot Function:
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Phenotypes From GWAS Catalog for STX5 Gene

Gene Ontology (GO) - Molecular Function for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IDA 15215310
GO:0005515 protein binding IPI 18167358
GO:0045296 cadherin binding IDA 25468996
GO:0047485 protein N-terminus binding IPI 19536132
genes like me logo Genes that share ontologies with STX5: view
genes like me logo Genes that share phenotypes with STX5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STX5

CRISPR Products

miRNA for STX5 Gene

miRTarBase miRNAs that target STX5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX5 Gene

Localization for STX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX5 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250 UniProtKB:Q08851}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 4
plasma membrane 3
nucleus 2
endosome 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 9464276
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with STX5: view

Pathways & Interactions for STX5 Gene

genes like me logo Genes that share pathways with STX5: view

Gene Ontology (GO) - Biological Process for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0034498 early endosome to Golgi transport IMP 17389686
genes like me logo Genes that share ontologies with STX5: view

No data available for SIGNOR curated interactions for STX5 Gene

Drugs & Compounds for STX5 Gene

(1) Drugs for STX5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with STX5: view

Transcripts for STX5 Gene

mRNA/cDNA for STX5 Gene

Unigene Clusters for STX5 Gene

Syntaxin 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX5

Alternative Splicing Database (ASD) splice patterns (SP) for STX5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP4: -
SP5: -

Relevant External Links for STX5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX5 Gene

Protein differential expression in normal tissues from HIPED for STX5 Gene

This gene is overexpressed in Cervix (13.6) and Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STX5 Gene

Protein tissue co-expression partners for STX5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX5 Gene:


SOURCE GeneReport for Unigene cluster for STX5 Gene:


Evidence on tissue expression from TISSUES for STX5 Gene

  • Heart(4.2)
  • Kidney(4.2)
  • Liver(4.2)
  • Blood(4.1)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with STX5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX5 Gene

Orthologs for STX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX5 34 33
  • 99.22 (n)
(Bos Taurus)
Mammalia STX5 34 33
  • 94.08 (n)
(Canis familiaris)
Mammalia STX5 34 33
  • 93.52 (n)
(Rattus norvegicus)
Mammalia Stx5 33
  • 89.74 (n)
(Mus musculus)
Mammalia Stx5a 16 34 33
  • 89.45 (n)
(Monodelphis domestica)
Mammalia STX5 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia STX5 34
  • 65 (a)
(Anolis carolinensis)
Reptilia STX5 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stx5 33
  • 72.72 (n)
Str.1892 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14190 33
(Danio rerio)
Actinopterygii stx5a 34 33
  • 74.59 (n)
stx5al 34
  • 66 (a)
wufb81g12 33
fruit fly
(Drosophila melanogaster)
Insecta Syx5 34 33
  • 59.91 (n)
(Caenorhabditis elegans)
Secernentea syx-5 34 33
  • 48.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR210C 33
  • 47.77 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17798g 33
  • 45.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SED5 36 34 33
  • 43.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP32 33
  • 48.53 (n)
(Oryza sativa)
Liliopsida Os01g0179200 33
  • 48.75 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01907 33
  • 51.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sed5 33
  • 49.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2930 34
  • 49 (a)
Species where no ortholog for STX5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX5 Gene

Gene Tree for STX5 (if available)
Gene Tree for STX5 (if available)
Evolutionary constrained regions (ECRs) for STX5: view image

Paralogs for STX5 Gene

No data available for Paralogs for STX5 Gene

Variants for STX5 Gene

Sequence variations from dbSNP and Humsavar for STX5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_035642 A breast cancer sample p.Gln79His
rs1000074062 -- 62,818,516(-) C/T intron_variant
rs1000109023 -- 62,826,835(-) G/A intron_variant
rs1000484155 -- 62,816,944(-) TTGCTCT/ intron_variant
rs1000551267 -- 62,815,528(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STX5 Gene

Variant ID Type Subtype PubMed ID
esv991674 OTHER inversion 20482838
nsv1159903 CNV duplication 26073780
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Variation tolerance for STX5 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX5 Gene

Disorders for STX5 Gene

Additional Disease Information for STX5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STX5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX5 Gene

Publications for STX5 Gene

  1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PMID: 9188044) Ravichandran V … Roche PA (Journal of molecular neuroscience : MN 1997) 2 3 4 22 58
  2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PMID: 19536132) Laufman O … Lev S (The EMBO journal 2009) 3 4 22 58
  3. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PMID: 18167358) Diao A … Lowe M (The Journal of biological chemistry 2008) 3 22 58
  4. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. (PMID: 18843296) Mancias JD … Goldberg J (The EMBO journal 2008) 3 4 58
  5. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PMID: 17389686) Amessou M … Johannes L (Journal of cell science 2007) 3 22 58

Products for STX5 Gene

Sources for STX5 Gene

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