Aliases for STRN Gene

Aliases for STRN Gene

  • Striatin 2 3 4 5
  • Protein Phosphatase 2 Regulatory Subunit B'''Alpha 2 3
  • Striatin, Calmodulin Binding Protein 3
  • Striatin, Calmodulin-Binding Protein 2
  • PPP2R6A 3
  • SG2NA 3
  • STRN1 3

External Ids for STRN Gene

Previous GeneCards Identifiers for STRN Gene

  • GC02M037041
  • GC02M037222
  • GC02M037050
  • GC02M036987
  • GC02M036924

Summaries for STRN Gene

GeneCards Summary for STRN Gene

STRN (Striatin) is a Protein Coding gene. Diseases associated with STRN include Cerebral Cavernous Malformations 3 and Cherubism. Among its related pathways are Plasma membrane estrogen receptor signaling and Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. Gene Ontology (GO) annotations related to this gene include estrogen receptor binding. An important paralog of this gene is STRN3.

UniProtKB/Swiss-Prot Summary for STRN Gene

  • Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Gene Wiki entry for STRN Gene

Additional gene information for STRN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STRN Gene

Genomics for STRN Gene

GeneHancer (GH) Regulatory Elements for STRN Gene

Promoters and enhancers for STRN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J036961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 512.5 +1.3 1345 7.3 EP300 HNRNPK ZBTB40 ZNF217 TCF12 POLR2G SP1 GTF2E2 PHF8 SIX5 STRN GPATCH11 piR-50437-373 HEATR5B
GH02J036902 Promoter/Enhancer 0.8 EPDnew Ensembl 520.3 +62.5 62456 3 CEBPG CEBPB ZFP91 HLF ZNF24 STRN RNU6-577P piR-50437-373 RF00026-529
GH02J037012 Promoter/Enhancer 1.1 Ensembl ENCODE 16.4 -46.8 -46755 1.4 EP300 MEF2C BCL11A CBFB IRF1 MEF2B SPI1 ELF1 IRF4 IKZF1 STRN GPATCH11 L13304-019 L13715-015 L13714-263 HEATR5B
GH02J037004 Enhancer 0.8 ENCODE 18 -38.7 -38684 0.7 CTCF EP300 REST MEF2C RCOR1 RAD21 TRIM22 SMC3 BCL11A CBFB STRN L13304-019 L13715-015 L13714-263 HEATR5B
GH02J037019 Enhancer 0.7 Ensembl ENCODE 20.3 -54.3 -54283 2.3 JUND NR2F2 USF1 JUN POLR2A USF2 CEBPB STRN L13714-263 L13304-019 L13715-015 HEATR5B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STRN

Top Transcription factor binding sites by QIAGEN in the STRN gene promoter:
  • AML1a
  • Elk-1
  • HSF1 (long)
  • HSF1short
  • p53
  • POU2F1
  • POU2F1a
  • RFX1
  • RORalpha1
  • SRY

Genomic Locations for STRN Gene

Genomic Locations for STRN Gene
128,860 bases
Minus strand
128,775 bases
Minus strand

Genomic View for STRN Gene

Genes around STRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN Gene

Proteins for STRN Gene

  • Protein details for STRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3KP65
    • Q53TQ8
    • Q9NP38

    Protein attributes for STRN Gene

    780 amino acids
    Molecular mass:
    86132 Da
    Quaternary structure:
    • Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).

    Alternative splice isoforms for STRN Gene


neXtProt entry for STRN Gene

Post-translational modifications for STRN Gene

  • Ubiquitination at Lys353
  • Modification sites at PhosphoSitePlus

Other Protein References for STRN Gene

No data available for DME Specific Peptides for STRN Gene

Domains & Families for STRN Gene

Gene Families for STRN Gene

Protein Domains for STRN Gene

Suggested Antigen Peptide Sequences for STRN Gene

GenScript: Design optimal peptide antigens:
  • STRN protein (Q3B874_HUMAN)
  • Striatin (STRN_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat striatin family.
  • Belongs to the WD repeat striatin family.
genes like me logo Genes that share domains with STRN: view

Function for STRN Gene

Molecular function for STRN Gene

UniProtKB/Swiss-Prot Function:
Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.
GENATLAS Biochemistry:
striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and olfactory system

Phenotypes From GWAS Catalog for STRN Gene

Gene Ontology (GO) - Molecular Function for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17540176
GO:0005516 calmodulin binding NAS,IBA 9693043
GO:0030331 estrogen receptor binding IPI 15569929
GO:0044877 protein-containing complex binding IDA,IBA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN: view
genes like me logo Genes that share phenotypes with STRN: view

Animal Models for STRN Gene

MGI Knock Outs for STRN:
  • Strn Strn<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for STRN Gene

miRTarBase miRNAs that target STRN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STRN Gene

Localization for STRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRN gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
nucleus 3
cytosol 3
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005923 bicellular tight junction IDA 18502210
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane ISS --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with STRN: view

Pathways & Interactions for STRN Gene

PathCards logo

SuperPathways for STRN Gene

SuperPathway Contained pathways
1 Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
2 Plasma membrane estrogen receptor signaling
genes like me logo Genes that share pathways with STRN: view

Pathways by source for STRN Gene

1 BioSystems pathway for STRN Gene
1 GeneGo (Thomson Reuters) pathway for STRN Gene
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Gene Ontology (GO) - Biological Process for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007626 locomotory behavior ISS --
GO:0008285 negative regulation of cell proliferation IMP 18502210
GO:0016055 Wnt signaling pathway IMP 18502210
GO:0016358 dendrite development ISS --
GO:0070830 bicellular tight junction assembly NAS 18502210
genes like me logo Genes that share ontologies with STRN: view

No data available for SIGNOR curated interactions for STRN Gene

Drugs & Compounds for STRN Gene

No Compound Related Data Available

Transcripts for STRN Gene

mRNA/cDNA for STRN Gene

7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRN Gene

No ASD Table

Relevant External Links for STRN Gene

GeneLoc Exon Structure for

Expression for STRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STRN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STRN Gene

Protein tissue co-expression partners for STRN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STRN

SOURCE GeneReport for Unigene cluster for STRN Gene:


mRNA Expression by UniProt/SwissProt for STRN Gene:

Tissue specificity: Preferentially expressed in brain.

Evidence on tissue expression from TISSUES for STRN Gene

  • Liver(4.2)
  • Nervous system(3.9)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with STRN: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRN Gene

Orthologs for STRN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STRN 31 30
  • 99.74 (n)
(Canis familiaris)
Mammalia STRN 31 30
  • 95.07 (n)
(Bos Taurus)
Mammalia STRN 31 30
  • 94.06 (n)
(Ornithorhynchus anatinus)
Mammalia STRN 31
  • 92 (a)
(Mus musculus)
Mammalia Strn 17 31 30
  • 89.83 (n)
(Rattus norvegicus)
Mammalia Strn 30
  • 89.53 (n)
(Monodelphis domestica)
Mammalia STRN 31
  • 89 (a)
(Gallus gallus)
Aves STRN 31 30
  • 82.4 (n)
(Anolis carolinensis)
Reptilia STRN 31
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia strn 30
  • 76.35 (n)
Str.20192 30
(Danio rerio)
Actinopterygii zgc:158357 30
  • 69.84 (n)
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cka 31
  • 48 (a)
(Caenorhabditis elegans)
Secernentea cash-1 31
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 31
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10811 31
  • 51 (a)
Species where no ortholog for STRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRN Gene

Gene Tree for STRN (if available)
Gene Tree for STRN (if available)
Evolutionary constrained regions (ECRs) for STRN: view image

Paralogs for STRN Gene

Paralogs for STRN Gene

(2) SIMAP similar genes for STRN Gene using alignment to 2 proteins:

  • Q3B874_HUMAN Pseudogenes for STRN Gene

genes like me logo Genes that share paralogs with STRN: view

Variants for STRN Gene

Additional dbSNP identifiers (rs#s) for STRN Gene

Structural Variations from Database of Genomic Variants (DGV) for STRN Gene

Variant ID Type Subtype PubMed ID
dgv3790n100 CNV gain 25217958
esv2719925 CNV deletion 23290073
nsv1144895 CNV deletion 24896259
nsv428395 CNV gain 18775914
nsv456363 CNV gain 19166990
nsv472064 CNV novel sequence insertion 20440878
nsv581470 CNV gain 21841781
nsv828931 CNV gain 20364138
nsv828942 CNV loss 20364138
nsv961027 CNV duplication 23825009
nsv963787 CNV duplication 23825009

Variation tolerance for STRN Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STRN Gene

Disorders for STRN Gene

MalaCards: The human disease database

(2) MalaCards diseases for STRN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral cavernous malformations 3
  • cavernous angiomatous malformations
  • crbm
- elite association - COSMIC cancer census association via MalaCards
Search STRN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STRN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRN Gene

Publications for STRN Gene

  1. Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PMID: 9693043) Moqrich A … Castets F (Genomics 1998) 2 3 4 23 54
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41 54
  3. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 23 54
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 41 54
  5. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PMID: 18502210) Breitman M … Rosin-Arbesfeld R (Biochimica et biophysica acta 2008) 3 23 54

Products for STRN Gene

Sources for STRN Gene