Aliases for NEK4 Gene
External Ids for NEK4 Gene
Previous HGNC Symbols for NEK4 Gene
Previous GeneCards Identifiers for NEK4 Gene
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
GeneCards Summary for NEK4 Gene
NEK4 (NIMA Related Kinase 4) is a Protein Coding gene. Diseases associated with NEK4 include Ciliopathy. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K4.
UniProtKB/Swiss-Prot Summary for NEK4 Gene
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.