External Ids for SP2 Gene
Previous GeneCards Identifiers for SP2 Gene
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
GeneCards Summary for SP2 Gene
SP2 (Sp2 Transcription Factor) is a Protein Coding gene. Diseases associated with SP2 include Early-Onset Familial Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding and histone deacetylase binding. An important paralog of this gene is SP4.
UniProtKB/Swiss-Prot for SP2 Gene
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.