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Aliases for SOX15 Gene

Aliases for SOX15 Gene

  • SRY-Box 15 2 3 5
  • SRY (Sex Determining Region Y)-Box 20 2 3
  • SRY (Sex Determining Region Y)-Box 15 2 3
  • SOX20 3 4
  • SOX26 3 4
  • SOX27 3 4
  • Protein SOX-15 3
  • Protein SOX-12 4
  • Protein SOX-20 4
  • SRY Box 15 2
  • SOX12 4

External Ids for SOX15 Gene

Previous HGNC Symbols for SOX15 Gene

  • SOX20

Previous GeneCards Identifiers for SOX15 Gene

  • GC17M007905
  • GC17M008231
  • GC17M007434
  • GC17M007692
  • GC17M007433
  • GC17M007436
  • GC17M007491
  • GC17M007385

Summaries for SOX15 Gene

Entrez Gene Summary for SOX15 Gene

  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX15 Gene

SOX15 (SRY-Box 15) is a Protein Coding gene. Among its related pathways are ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is SOX3.

UniProtKB/Swiss-Prot for SOX15 Gene

  • Binds to the 5-AACAAT-3 sequence.

Gene Wiki entry for SOX15 Gene

Additional gene information for SOX15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX15 Gene

Genomics for SOX15 Gene

GeneHancer (GH) Regulatory Elements for SOX15 Gene

Promoters and enhancers for SOX15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007586 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 860 5.7 PKNOX1 ARID4B KLF17 SIN3A ZNF2 RAD21 ZNF335 GLIS2 ZNF143 SMARCC2 GC17M007593 SOX15 SAT2 TNFSF12 CHRNB1 ATP1B2 LOC100996842 MPDU1 FXR2
GH17I007613 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13 -24.4 -24392 2.9 HDGF PKNOX1 ATF1 ARID4B SIN3A YY1 GTF3C2 POLR2B GLIS2 ARID2 FXR2 SHBG TNFSF12 SNORD10 SOX15 LOC100996842 MPDU1 DVL2 ATP1B2 SNORA48
GH17I007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.7 +109.6 109581 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 DVL2 PFAS SNORD10 CTC1 WRAP53 SNORA48 CNTROB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SOX15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SOX15 gene promoter:

Genomic Locations for SOX15 Gene

Genomic Locations for SOX15 Gene
chr17:7,588,178-7,590,170
(GRCh38/hg38)
Size:
1,993 bases
Orientation:
Minus strand
chr17:7,491,496-7,493,488
(GRCh37/hg19)

Genomic View for SOX15 Gene

Genes around SOX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX15 Gene

Proteins for SOX15 Gene

  • Protein details for SOX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60248-SOX15_HUMAN
    Recommended name:
    Protein SOX-15
    Protein Accession:
    O60248
    Secondary Accessions:
    • B4DWU7
    • D3DTQ0
    • P35717
    • Q9Y6W7

    Protein attributes for SOX15 Gene

    Size:
    233 amino acids
    Molecular mass:
    25251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOX15 Gene

Post-translational modifications for SOX15 Gene

No Post-translational modifications

Other Protein References for SOX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX15 Gene

Domains & Families for SOX15 Gene

Gene Families for SOX15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SOX15 Gene

Suggested Antigen Peptide Sequences for SOX15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOX15: view

No data available for UniProtKB/Swiss-Prot for SOX15 Gene

Function for SOX15 Gene

Molecular function for SOX15 Gene

UniProtKB/Swiss-Prot Function:
Binds to the 5-AACAAT-3 sequence.

Phenotypes From GWAS Catalog for SOX15 Gene

Gene Ontology (GO) - Molecular Function for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0003677 DNA binding NAS 8332506
GO:0003682 chromatin binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 8332506
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SOX15: view
genes like me logo Genes that share phenotypes with SOX15: view

Animal Models for SOX15 Gene

MGI Knock Outs for SOX15:
Targeted motifs for SOX15 Gene
HOMER Transcription Factor Regulatory Elements motif SOX15
  • Consensus sequence: RAACAATGGN Submotif: canonical Cell Type: CPA GEO ID: GSE62909

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for SOX15 Gene

Localization for SOX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOX15 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (4)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8332506
GO:0005737 cytoplasm IEA --
GO:0044798 nuclear transcription factor complex IEA --
genes like me logo Genes that share ontologies with SOX15: view

Pathways & Interactions for SOX15 Gene

SuperPathways for SOX15 Gene

SuperPathway Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX15: view

Pathways by source for SOX15 Gene

1 Qiagen pathway for SOX15 Gene

Gene Ontology (GO) - Biological Process for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS 17363903
GO:0006325 chromatin organization NAS 8332506
GO:0006355 regulation of transcription, DNA-templated NAS 8332506
GO:0006357 regulation of transcription by RNA polymerase II TAS 9540826
GO:0008584 male gonad development TAS 9540826
genes like me logo Genes that share ontologies with SOX15: view

No data available for SIGNOR curated interactions for SOX15 Gene

Drugs & Compounds for SOX15 Gene

No Compound Related Data Available

Transcripts for SOX15 Gene

mRNA/cDNA for SOX15 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX15 Gene

SRY (sex determining region Y)-box 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX15 Gene

No ASD Table

Relevant External Links for SOX15 Gene

GeneLoc Exon Structure for
SOX15
ECgene alternative splicing isoforms for
SOX15

Expression for SOX15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX15 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Skin - Sun Exposed (Lower leg) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SOX15 Gene:

SOX15

SOURCE GeneReport for Unigene cluster for SOX15 Gene:

Hs.95582

mRNA Expression by UniProt/SwissProt for SOX15 Gene:

O60248-SOX15_HUMAN
Tissue specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Evidence on tissue expression from TISSUES for SOX15 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SOX15: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOX15 Gene

Orthologs for SOX15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOX15 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia SOX15 33 34
  • 85.12 (n)
cow
(Bos Taurus)
Mammalia SOX15 33 34
  • 84.69 (n)
mouse
(Mus musculus)
Mammalia Sox15 33 16 34
  • 79.8 (n)
zebrafish
(Danio rerio)
Actinopterygii sox19b 34
  • 32 (a)
ManyToMany
sox19a 34
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta SoxN 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sox-2 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for SOX15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SOX15 Gene

ENSEMBL:
Gene Tree for SOX15 (if available)
TreeFam:
Gene Tree for SOX15 (if available)

Paralogs for SOX15 Gene

(17) SIMAP similar genes for SOX15 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SOX15 Gene

genes like me logo Genes that share paralogs with SOX15: view

Variants for SOX15 Gene

Sequence variations from dbSNP and Humsavar for SOX15 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs4227 benign, Congenital disorder of glycosylation 7,587,859(-) G/T downstream_transcript_variant
rs543253078 uncertain-significance, Congenital disorder of glycosylation 7,588,074(-) A/AA downstream_transcript_variant
rs545206972 uncertain-significance, Congenital disorder of glycosylation 7,588,013(-) C/T downstream_transcript_variant
rs878936939 uncertain-significance, Congenital disorder of glycosylation 7,587,806(-) A/G/T downstream_transcript_variant
rs1000051307 -- 7,589,842(-) G/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SOX15 Gene

Variant ID Type Subtype PubMed ID
nsv574322 CNV loss 21841781
nsv457659 CNV loss 19166990
esv2422288 CNV deletion 17116639

Variation tolerance for SOX15 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOX15 Gene

Human Gene Mutation Database (HGMD)
SOX15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX15 Gene

Disorders for SOX15 Gene

Additional Disease Information for SOX15

No disorders were found for SOX15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX15 Gene

Publications for SOX15 Gene

  1. SOX20, a new member of the SOX gene family, is located on chromosome 17p13. (PMID: 8978787) Meyer J … Scherer G (Cytogenetics and cell genetics 1996) 2 3 4 58
  2. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu XQ … Liu JJ (Nature genetics 2011) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. cDNA characterization and high resolution mapping of the human SOX20 gene. (PMID: 9880678) Vujić M … Stevanović M (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 3 4 58
  5. Isolation and expression of a human SRY-related cDNA hSOX20. (PMID: 9540826) Hiraoka Y … Aiso S (Biochimica et biophysica acta 1998) 3 4 58

Products for SOX15 Gene

Sources for SOX15 Gene

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