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Aliases for SOD3 Gene

Aliases for SOD3 Gene

  • Superoxide Dismutase 3 2 3 5
  • Superoxide Dismutase 3, Extracellular 2 3
  • EC-SOD 3 4
  • Extracellular Superoxide Dismutase [Cu-Zn] 3
  • Testicular Tissue Protein Li 175 3
  • EC 4

External Ids for SOD3 Gene

Previous GeneCards Identifiers for SOD3 Gene

  • GC04P024921
  • GC04P024484
  • GC04P024546
  • GC04P024472
  • GC04P024139

Summaries for SOD3 Gene

Entrez Gene Summary for SOD3 Gene

  • This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

GeneCards Summary for SOD3 Gene

SOD3 (Superoxide Dismutase 3) is a Protein Coding gene. Diseases associated with SOD3 include Asbestosis and Diabetic Polyneuropathy. Among its related pathways are Copper homeostasis and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is SOD1.

UniProtKB/Swiss-Prot for SOD3 Gene

  • Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Gene Wiki entry for SOD3 Gene

Additional gene information for SOD3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOD3 Gene

Genomics for SOD3 Gene

GeneHancer (GH) Regulatory Elements for SOD3 Gene

Promoters and enhancers for SOD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J024794 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 655.3 +5.5 5544 2.7 FOXA2 TEAD4 TAL1 TCF12 CTBP1 POLR2A NCOR1 CBFA2T2 FOS RXRA SOD3 GC04M024806
GH04J024855 Enhancer 0.9 Ensembl ENCODE 11.3 +67.6 67602 3 BATF IRF4 POLR2A EED ETV6 FOS BCLAF1 IKZF2 RUNX3 CREM SOD3 LGI2 GC04M024806 GC04P024947 CCDC149
GH04J024762 Enhancer 0.5 ENCODE 17.1 -25.9 -25864 2.2 CTBP1 PKNOX1 GATA3 SIN3A DPF2 FOXA1 SOD3 ENSG00000251638 PIR57270
GH04J024752 Enhancer 0.6 ENCODE 11.2 -36.0 -36048 2 PKNOX1 RFX1 DPF2 MNT FOXA1 CREB1 CUX1 FOS NFE2L2 SOD3 LGI2 ENSG00000251638 PIR57270
GH04J024730 Enhancer 0.4 ENCODE 16 -59.1 -59145 1.3 JUND ZBTB40 PIR57270 SOD3 CCDC149 ENSG00000251638
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SOD3 gene promoter:
  • RORalpha1
  • Gfi-1
  • POU2F1a
  • POU2F1
  • Nkx5-1
  • E47
  • Chx10
  • SRF (504 AA)
  • SRF
  • STAT5B

Genomic Locations for SOD3 Gene

Genomic Locations for SOD3 Gene
10,934 bases
Plus strand
10,934 bases
Plus strand

Genomic View for SOD3 Gene

Genes around SOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD3 Gene

Proteins for SOD3 Gene

  • Protein details for SOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Extracellular superoxide dismutase [Cu-Zn]
    Protein Accession:
    Secondary Accessions:
    • Q5U781
    • Q6FHA2

    Protein attributes for SOD3 Gene

    240 amino acids
    Molecular mass:
    25851 Da
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for SOD3 Gene

neXtProt entry for SOD3 Gene

Post-translational modifications for SOD3 Gene

  • Glycosylation at isoforms=230, isoforms=229, and posLast=107107
  • Modification sites at PhosphoSitePlus

Other Protein References for SOD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOD3 Gene

Domains & Families for SOD3 Gene

Gene Families for SOD3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SOD3 Gene

Suggested Antigen Peptide Sequences for SOD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Cu-Zn superoxide dismutase family.
  • Belongs to the Cu-Zn superoxide dismutase family.
genes like me logo Genes that share domains with SOD3: view

Function for SOD3 Gene

Molecular function for SOD3 Gene

UniProtKB/Swiss-Prot Function:
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
UniProtKB/Swiss-Prot CatalyticActivity:
2 superoxide + 2 H(+) = O(2) + H(2)O(2).
GENATLAS Biochemistry:
superoxide dismutase 3,extracellular,predominantly expressed in heart,placenta,pancreas,lung,catabolic pathway of activated oxygen species,free radical detoxification

Enzyme Numbers (IUBMB) for SOD3 Gene

Phenotypes From GWAS Catalog for SOD3 Gene

Gene Ontology (GO) - Molecular Function for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004784 superoxide dismutase activity IBA,TAS --
GO:0005507 copper ion binding IBA --
GO:0005515 protein binding IPI 15528465
GO:0008201 heparin binding IEA --
GO:0008270 zinc ion binding IBA --
genes like me logo Genes that share ontologies with SOD3: view
genes like me logo Genes that share phenotypes with SOD3: view

Animal Models for SOD3 Gene

MGI Knock Outs for SOD3:
  • Sod3 Sod3<tm1Mrkl>

Animal Model Products

miRNA for SOD3 Gene

miRTarBase miRNAs that target SOD3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOD3 Gene

Localization for SOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD3 Gene

Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOD3 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 3
mitochondrion 2
peroxisome 2
plasma membrane 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,TAS --
GO:0005615 extracellular space IDA,IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA,IEA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with SOD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SOD3 Gene

Pathways & Interactions for SOD3 Gene

genes like me logo Genes that share pathways with SOD3: view

Gene Ontology (GO) - Biological Process for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006801 superoxide metabolic process IEA --
GO:0006979 response to oxidative stress IEA --
GO:0019430 removal of superoxide radicals IEA --
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with SOD3: view

No data available for SIGNOR curated interactions for SOD3 Gene

Drugs & Compounds for SOD3 Gene

(27) Drugs for SOD3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 202
Oxygen Approved, Vet_approved Pharma 0
Zinc Approved, Investigational Pharma 2430
Manganese Approved Nutra 37
Hydrogen peroxide Approved, Vet_approved Pharma 73

(23) Additional Compounds for SOD3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
  • (O2)(.-)
  • Dioxide(1-)
  • Hyperoxid
  • Hyperoxide
  • O2(.-)
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SOD3: view

Transcripts for SOD3 Gene

mRNA/cDNA for SOD3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(208) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOD3 Gene

Superoxide dismutase 3, extracellular:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOD3 Gene

No ASD Table

Relevant External Links for SOD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOD3 Gene

This gene is overexpressed in Artery - Aorta (x7.8), Esophagus - Muscularis (x4.5), and Artery - Coronary (x4.5).

Protein differential expression in normal tissues from HIPED for SOD3 Gene

This gene is overexpressed in Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOD3 Gene

Protein tissue co-expression partners for SOD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOD3 Gene:


SOURCE GeneReport for Unigene cluster for SOD3 Gene:


mRNA Expression by UniProt/SwissProt for SOD3 Gene:

Tissue specificity: Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

Evidence on tissue expression from TISSUES for SOD3 Gene

  • Blood(4.5)
  • Liver(4.3)
  • Intestine(4.2)
  • Bone marrow(4)
  • Nervous system(2.9)
  • Lung(2.8)
  • Heart(2.6)
  • Kidney(2.5)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with SOD3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SOD3 Gene

Orthologs for SOD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOD3 34 33
  • 100 (n)
(Canis familiaris)
Mammalia SOD3 34 33
  • 83.25 (n)
(Bos Taurus)
Mammalia SOD3 33
  • 83.19 (n)
  • 70 (a)
(Mus musculus)
Mammalia Sod3 16 34 33
  • 76.76 (n)
(Rattus norvegicus)
Mammalia Sod3 33
  • 76.13 (n)
(Monodelphis domestica)
Mammalia SOD3 34
  • 50 (a)
(Gallus gallus)
Aves SOD3 34 33
  • 57.14 (n)
(Anolis carolinensis)
Reptilia SOD3 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sod3 33
  • 53.72 (n)
(Danio rerio)
Actinopterygii sod3a 34 33
  • 54.48 (n)
sod3b 34 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sod3 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea sod-4 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD1 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5360 34
  • 39 (a)
Species where no ortholog for SOD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD3 Gene

Gene Tree for SOD3 (if available)
Gene Tree for SOD3 (if available)
Evolutionary constrained regions (ECRs) for SOD3: view image

Paralogs for SOD3 Gene

Paralogs for SOD3 Gene

(1) SIMAP similar genes for SOD3 Gene using alignment to 2 proteins:

  • M0R1V4_HUMAN
genes like me logo Genes that share paralogs with SOD3: view

Variants for SOD3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SOD3 Gene

The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface.

Sequence variations from dbSNP and Humsavar for SOD3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1799895 pathogenic, Superoxide dismutase, elevated extracellular 24,800,212(+) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001239092 -- 24,799,068(+) C/T intron_variant
rs1001999409 -- 24,800,483(+) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1002154904 -- 24,795,394(+) A/C upstream_transcript_variant
rs1002493412 -- 24,794,265(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SOD3 Gene

Variant ID Type Subtype PubMed ID
nsv829887 CNV gain+loss 17160897

Variation tolerance for SOD3 Gene

Gene Damage Index Score: 7.32; 81.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOD3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for SOD3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SOD3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • idiopathic interstitial pneumonitis - from asbestos exposure
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
myocardial stunning
optic neuritis
diabetic neuropathy
  • diabetic neuropathies
- elite association - COSMIC cancer census association via MalaCards
Search SOD3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOD3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SOD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOD3 Gene

Publications for SOD3 Gene

  1. The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. (PMID: 19289127) Antonyuk SV … Hasnain SS (Journal of molecular biology 2009) 3 4 22 58
  2. Manganese and extracellular superoxide dismutase polymorphisms and risk for asbestosis. (PMID: 19636420) Franko A … Dolzan V (Journal of biomedicine & biotechnology 2009) 3 22 44 58
  3. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. (PMID: 18948423) Arcaroli JJ … Crapo JD (American journal of respiratory and critical care medicine 2009) 3 22 44 58
  4. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (PMID: 19108943) Rosta K … Vér A (European journal of obstetrics, gynecology, and reproductive biology 2009) 3 22 44 58
  5. A haplotype-based case-control study examining human extracellular superoxide dismutase gene and essential hypertension. (PMID: 18971527) Naganuma T … Usami R (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 22 44 58

Products for SOD3 Gene

Sources for SOD3 Gene

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