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Aliases for BNIP2 Gene

Aliases for BNIP2 Gene

  • BCL2 Interacting Protein 2 2 3 5
  • BCL2/Adenovirus E1B 19kDa Interacting Protein 2 2 3
  • NIP2 3 4
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 2 3
  • BNIP-2 3

External Ids for BNIP2 Gene

Previous GeneCards Identifiers for BNIP2 Gene

  • GC15M055513
  • GC15M053003
  • GC15M057534
  • GC15M057671
  • GC15M057742
  • GC15M059951
  • GC15M036777

Summaries for BNIP2 Gene

Entrez Gene Summary for BNIP2 Gene

  • This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for BNIP2 Gene

BNIP2 (BCL2 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Myogenesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is PRUNE2.

UniProtKB/Swiss-Prot for BNIP2 Gene

  • Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.

Gene Wiki entry for BNIP2 Gene

Additional gene information for BNIP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIP2 Gene

Genomics for BNIP2 Gene

GeneHancer (GH) Regulatory Elements for BNIP2 Gene

Promoters and enhancers for BNIP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J059684 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.4 +2.0 1956 7.1 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 BNIP2 ENSG00000259238 GTF2A2 SLTM RNF111 ICE2 PIR36988
GH15J059691 Enhancer 0.6 ENCODE 650.7 -1.9 -1863 0.2 CTCF ZNF654 TRIM22 ZNF384 RAD21 ZNF664 SMC3 ZNF143 BNIP2 GTF2A2 GC15M059729
GH15J060476 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.8 -788.9 -788893 4.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ICE2 RORA-AS1 ENSG00000259481 BNIP2 RPL21P114 ANXA2 RPS3AP6 RORA-AS2 PIGHP1 GC15M060398
GH15J059368 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.5 +318.1 318067 5.4 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ETS1 GLIS2 MYO1E FAM81A RNF111 BNIP2 PIGHP1 RPS3AP6 ENSG00000259735
GH15J058931 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +756.4 756380 4.1 FOXA2 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B SLTM RNF111 BNIP2 ENSG00000225798 PIGHP1 ENSG00000259353
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BNIP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BNIP2 gene promoter:
  • Sox5
  • RORalpha1
  • HNF-3beta
  • Cart-1
  • AML1a
  • Max1
  • c-Myc
  • CUTL1
  • POU6F1 (c2)
  • RSRFC4

Genomic Locations for BNIP2 Gene

Genomic Locations for BNIP2 Gene
30,389 bases
Minus strand
30,389 bases
Minus strand

Genomic View for BNIP2 Gene

Genes around BNIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP2 Gene

Proteins for BNIP2 Gene

  • Protein details for BNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DS94

    Protein attributes for BNIP2 Gene

    314 amino acids
    Molecular mass:
    36018 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BNIP2 Gene


neXtProt entry for BNIP2 Gene

Post-translational modifications for BNIP2 Gene

  • Ubiquitination at Lys267, posLast=228228, and posLast=219219
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BNIP2 Gene

Domains & Families for BNIP2 Gene

Gene Families for BNIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for BNIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BNIP2: view

No data available for UniProtKB/Swiss-Prot for BNIP2 Gene

Function for BNIP2 Gene

Molecular function for BNIP2 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.

Phenotypes From GWAS Catalog for BNIP2 Gene

Gene Ontology (GO) - Molecular Function for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004309 exopolyphosphatase activity IBA --
GO:0005096 GTPase activator activity TAS 10799524
GO:0005509 calcium ion binding TAS 7954800
GO:0005515 protein binding IPI 7954800
GO:0042802 identical protein binding IBA --
genes like me logo Genes that share ontologies with BNIP2: view
genes like me logo Genes that share phenotypes with BNIP2: view

Animal Models for BNIP2 Gene

MGI Knock Outs for BNIP2:
  • Bnip2 Bnip2<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BNIP2 Gene

Localization for BNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNIP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BNIP2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
golgi apparatus 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 7954800
GO:0005737 cytoplasm IDA 7954800
GO:0005814 centriole IEA --
GO:0005829 cytosol TAS,IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with BNIP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BNIP2 Gene

Pathways & Interactions for BNIP2 Gene

genes like me logo Genes that share pathways with BNIP2: view

Pathways by source for BNIP2 Gene

3 Reactome pathways for BNIP2 Gene
1 GeneGo (Thomson Reuters) pathway for BNIP2 Gene

SIGNOR curated interactions for BNIP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006798 polyphosphate catabolic process IBA --
GO:0006915 apoptotic process IPI 7954800
GO:0007098 centrosome cycle IEA --
GO:0043066 negative regulation of apoptotic process TAS 7954800
GO:0043410 positive regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with BNIP2: view

Drugs & Compounds for BNIP2 Gene

No Compound Related Data Available

Transcripts for BNIP2 Gene

mRNA/cDNA for BNIP2 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BNIP2 Gene

BCL2/adenovirus E1B 19kDa interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP2

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for BNIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BNIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BNIP2 Gene

This gene is overexpressed in Pancreas (22.9), Testis (19.0), Platelet (7.7), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BNIP2 Gene

Protein tissue co-expression partners for BNIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BNIP2 Gene:


SOURCE GeneReport for Unigene cluster for BNIP2 Gene:


Evidence on tissue expression from TISSUES for BNIP2 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Blood(4.1)
  • Eye(4.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with BNIP2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BNIP2 Gene

Orthologs for BNIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BNIP2 34 33
  • 99.92 (n)
(Bos Taurus)
Mammalia BNIP2 34 33
  • 94.48 (n)
(Canis familiaris)
Mammalia BNIP2 34 33
  • 93.72 (n)
(Ornithorhynchus anatinus)
Mammalia BNIP2 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Bnip2 33
  • 87.07 (n)
(Mus musculus)
Mammalia Bnip2 16 34 33
  • 86.52 (n)
(Monodelphis domestica)
Mammalia BNIP2 34
  • 81 (a)
(Gallus gallus)
Aves BNIP2 34 33
  • 84.14 (n)
(Anolis carolinensis)
Reptilia BNIP2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bnip2 33
  • 78.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8459 33
(Danio rerio)
Actinopterygii LOC100332015 33
  • 72.45 (n)
bnip2 34 33
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11593 34 35
  • 25 (a)
Species where no ortholog for BNIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIP2 Gene

Gene Tree for BNIP2 (if available)
Gene Tree for BNIP2 (if available)
Evolutionary constrained regions (ECRs) for BNIP2: view image

Paralogs for BNIP2 Gene

Paralogs for BNIP2 Gene

(6) SIMAP similar genes for BNIP2 Gene using alignment to 4 proteins:

  • H7C096_HUMAN
  • H7C142_HUMAN
  • J3KN59_HUMAN
genes like me logo Genes that share paralogs with BNIP2: view

Variants for BNIP2 Gene

Sequence variations from dbSNP and Humsavar for BNIP2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000015947 -- 59,687,688(-) C/T intron_variant
rs1000030061 -- 59,666,425(-) G/C intron_variant
rs1000066852 -- 59,678,209(-) A/T intron_variant
rs1000219851 -- 59,685,447(-) G/A intron_variant
rs1000409896 -- 59,675,977(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BNIP2 Gene

Variant ID Type Subtype PubMed ID
esv3569653 CNV gain 25503493
esv3636646 CNV gain 21293372
esv3636647 CNV gain 21293372
nsv1043693 CNV loss 25217958
nsv1108960 CNV deletion 24896259
nsv523274 CNV loss 19592680
nsv527307 CNV gain 19592680
nsv569605 CNV loss 21841781
nsv7266 OTHER inversion 18451855
nsv984080 CNV duplication 23825009

Variation tolerance for BNIP2 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.33; 94.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BNIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIP2 Gene

Disorders for BNIP2 Gene

Additional Disease Information for BNIP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BNIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIP2 Gene

Publications for BNIP2 Gene

  1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PMID: 7954800) Boyd JM … Chinnadurai G (Cell 1994) 2 3 4 58
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  3. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. (PMID: 15652341) Zhou YT … Low BC (Experimental cell research 2005) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for BNIP2 Gene

Sources for BNIP2 Gene

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