Aliases for SNAPC4 Gene
External Ids for SNAPC4 Gene
Previous GeneCards Identifiers for SNAPC4 Gene
This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016]
GeneCards Summary for SNAPC4 Gene
SNAPC4 (Small Nuclear RNA Activating Complex Polypeptide 4) is a Protein Coding gene. Diseases associated with SNAPC4 include Spondylitis. Among its related pathways are RNA Polymerase III Transcription Initiation and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MYB.
UniProtKB/Swiss-Prot for SNAPC4 Gene
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.