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Aliases for SNAPC3 Gene

Aliases for SNAPC3 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 3 2 3 5
  • Proximal Sequence Element-Binding Transcription Factor Subunit Beta 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 3, 50kDa 2 3
  • Small Nuclear RNA Activating Complex, Polypeptide 3, 50kD 2 3
  • SnRNA-Activating Protein Complex 50 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Beta 3 4
  • SNAPc 50 KDa Subunit 3 4
  • PTF Subunit Beta 3 4
  • SNAPc Subunit 3 3 4
  • SNAP50 3 4
  • Small Nuclear RNA-Activating Complex Polypeptide 3 4
  • SnRNA-Activating Protein Complex Subunit 3 3
  • PTFbeta 3

External Ids for SNAPC3 Gene

Previous GeneCards Identifiers for SNAPC3 Gene

  • GC09P015588
  • GC09P015404

Summaries for SNAPC3 Gene

GeneCards Summary for SNAPC3 Gene

SNAPC3 (Small Nuclear RNA Activating Complex Polypeptide 3) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression.

UniProtKB/Swiss-Prot for SNAPC3 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC3 Gene

Additional gene information for SNAPC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC3 Gene

Genomics for SNAPC3 Gene

GeneHancer (GH) Regulatory Elements for SNAPC3 Gene

Promoters and enhancers for SNAPC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I015421 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.2 +0.3 307 3.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SNAPC3 PSIP1 RNU6-319P
GH09I015508 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.2 +88.4 88386 5.9 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 PSIP1 CCDC171 SNAPC3 ENSG00000278754
GH09I014432 Enhancer 1 Ensembl ENCODE 11.8 -989.0 -989027 2.3 HDAC1 ARNT SREBF2 ZNF2 RAD21 GTF3C2 TCF12 ZNF213 POLR3A FOS GC09P014433 TRH-GTG1-6 CDCA4P1 ZDHHC21 SNAPC3
GH09I016367 Enhancer 0.8 ENCODE dbSUPER 11.9 +945.6 945552 1.5 ZFP69B ZNF335 ZFHX2 GATA3 JUND ZNF366 ZNF692 ZNF585B ZNF629 FOS SNAPC3 ENSG00000231756 GC09P016344 GC09P016421
GH09I015430 Enhancer 0.7 Ensembl ENCODE 8.4 +8.1 8117 1.3 RFX1 FEZF1 MAFK EMSY RNU6-319P PSIP1 SNAPC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNAPC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNAPC3 gene promoter:

Genomic Locations for SNAPC3 Gene

Genomic Locations for SNAPC3 Gene
chr9:15,422,696-15,466,751
(GRCh38/hg38)
Size:
44,056 bases
Orientation:
Plus strand
chr9:15,422,702-15,465,951
(GRCh37/hg19)

Genomic View for SNAPC3 Gene

Genes around SNAPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC3 Gene

Proteins for SNAPC3 Gene

  • Protein details for SNAPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92966-SNPC3_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 3
    Protein Accession:
    Q92966
    Secondary Accessions:
    • D3DRI8
    • Q2VPI6
    • Q5T285

    Protein attributes for SNAPC3 Gene

    Size:
    411 amino acids
    Molecular mass:
    46753 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.

neXtProt entry for SNAPC3 Gene

Post-translational modifications for SNAPC3 Gene

  • Ubiquitination at isoforms=110, posLast=244244, posLast=287287, and posLast=395395
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNAPC3 Gene

Domains & Families for SNAPC3 Gene

Gene Families for SNAPC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SNAPC3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92966

UniProtKB/Swiss-Prot:

SNPC3_HUMAN :
  • Belongs to the SNAPC3/SRD2 family.
Family:
  • Belongs to the SNAPC3/SRD2 family.
genes like me logo Genes that share domains with SNAPC3: view

Function for SNAPC3 Gene

Molecular function for SNAPC3 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Phenotypes From GWAS Catalog for SNAPC3 Gene

Gene Ontology (GO) - Molecular Function for SNAPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SNAPC3: view
genes like me logo Genes that share phenotypes with SNAPC3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAPC3 Gene

Localization for SNAPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAPC3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nuclear bodies (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNAPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SNAPC3: view

Pathways & Interactions for SNAPC3 Gene

genes like me logo Genes that share pathways with SNAPC3: view

Gene Ontology (GO) - Biological Process for SNAPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 7715707
GO:0006383 transcription by RNA polymerase III TAS 7715707
GO:0009301 snRNA transcription TAS 7715707
genes like me logo Genes that share ontologies with SNAPC3: view

No data available for SIGNOR curated interactions for SNAPC3 Gene

Drugs & Compounds for SNAPC3 Gene

(1) Additional Compounds for SNAPC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNAPC3: view

Transcripts for SNAPC3 Gene

Unigene Clusters for SNAPC3 Gene

Small nuclear RNA activating complex, polypeptide 3, 50kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for SNAPC3 Gene

GeneLoc Exon Structure for
SNAPC3
ECgene alternative splicing isoforms for
SNAPC3

Expression for SNAPC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNAPC3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNAPC3 Gene



Protein tissue co-expression partners for SNAPC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNAPC3 Gene:

SNAPC3

SOURCE GeneReport for Unigene cluster for SNAPC3 Gene:

Hs.546299

Evidence on tissue expression from TISSUES for SNAPC3 Gene

  • Skin(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with SNAPC3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAPC3 Gene

Orthologs for SNAPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC3 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia SNAPC3 33 34
  • 90.19 (n)
cow
(Bos Taurus)
Mammalia SNAPC3 33 34
  • 88.78 (n)
mouse
(Mus musculus)
Mammalia Snapc3 33 16 34
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Snapc3 33
  • 83.91 (n)
oppossum
(Monodelphis domestica)
Mammalia SNAPC3 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAPC3 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAPC3 33 34
  • 70.88 (n)
lizard
(Anolis carolinensis)
Reptilia SNAPC3 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snapc3 33
  • 70.26 (n)
Str.4306 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23738 33
zebrafish
(Danio rerio)
Actinopterygii snapc3 33 34
  • 60.22 (n)
zgc56295 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003852 33
  • 43.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pbp49 34
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snpc-3.4 34
  • 22 (a)
OneToMany
snpc-3.1 34
  • 20 (a)
OneToMany
snpc-3.2 34
  • 20 (a)
OneToMany
snpc-3.3 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10344 34
  • 45 (a)
OneToOne
Species where no ortholog for SNAPC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAPC3 Gene

ENSEMBL:
Gene Tree for SNAPC3 (if available)
TreeFam:
Gene Tree for SNAPC3 (if available)

Paralogs for SNAPC3 Gene

No data available for Paralogs for SNAPC3 Gene

Variants for SNAPC3 Gene

Sequence variations from dbSNP and Humsavar for SNAPC3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000037035 -- 15,443,854(+) A/G intron_variant
rs1000141949 -- 15,439,421(+) C/G intron_variant
rs1000184641 -- 15,432,547(+) T/C intron_variant
rs1000221548 -- 15,435,155(+) C/T intron_variant
rs1000257620 -- 15,430,899(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC3 Gene

Variant ID Type Subtype PubMed ID
esv3619779 CNV loss 21293372
nsv1075607 CNV deletion 25765185
nsv1137424 CNV deletion 24896259
nsv517975 CNV loss 19592680
nsv831520 CNV loss 17160897

Variation tolerance for SNAPC3 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNAPC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC3 Gene

Disorders for SNAPC3 Gene

Additional Disease Information for SNAPC3

No disorders were found for SNAPC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC3 Gene

Publications for SNAPC3 Gene

  1. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. (PMID: 9003788) Henry RW … Hernandez N (The EMBO journal 1996) 2 3 4 22 58
  2. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PMID: 12621023) Hinkley CS … Henry RW (The Journal of biological chemistry 2003) 3 4 22 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. (PMID: 11056176) Ma B … Hernandez N (The Journal of biological chemistry 2001) 3 4 58

Products for SNAPC3 Gene

Sources for SNAPC3 Gene

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