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Aliases for SLC2A11 Gene

Aliases for SLC2A11 Gene

  • Solute Carrier Family 2 Member 11 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 11 2 3
  • Glucose Transporter Type 10 3 4
  • Glucose Transporter Type 11 3 4
  • GLUT10 3 4
  • GLUT11 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 11 3
  • Facilitative Glucose Transporter GLUT11 3
  • Glucose Transporter-Like Protein XI 3
  • Glucose Transporter Protein 10 3
  • Glucose Transporter Protein 11 3
  • GLUT-10 4
  • GLUT-11 4

External Ids for SLC2A11 Gene

Previous GeneCards Identifiers for SLC2A11 Gene

  • GC22U990207
  • GC22P020895
  • GC22P022523
  • GC22P024198
  • GC22P007184

Summaries for SLC2A11 Gene

Entrez Gene Summary for SLC2A11 Gene

  • This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for SLC2A11 Gene

SLC2A11 (Solute Carrier Family 2 Member 11) is a Protein Coding gene. Among its related pathways are PAK Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A5.

UniProtKB/Swiss-Prot for SLC2A11 Gene

  • Facilitative glucose transporter.

Gene Wiki entry for SLC2A11 Gene

Additional gene information for SLC2A11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A11 Gene

Genomics for SLC2A11 Gene

GeneHancer (GH) Regulatory Elements for SLC2A11 Gene

Promoters and enhancers for SLC2A11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J023856 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 675.1 +1.2 1204 2.9 HDGF SIN3A DMAP1 ZNF2 ZNF48 YY1 POLR2B GLIS2 ZNF143 ATF7 SLC2A11 ENSG00000272973 SPECC1L ENSG00000251357
GH22J023877 Promoter 0.5 EPDnew 650.3 +21.1 21093 0.1 PIRC109 RN7SL268P SLC2A11 GUSBP11 RGL4 ENSG00000279467 ENSG00000251357
GH22J023885 Promoter 0.5 EPDnew 650.3 +29.1 29054 0.1 PIR43943 SLC2A11 GSTT2B PIRC109 PIR47632 ENSG00000251357
GH22J024548 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.5 +696.8 696759 8.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SNRPD3 GGT1 GUCD1 ENSG00000272973 SGSM1 ENSG00000272578 UPB1 ADORA2A ARL5AP4 LOC100421614
GH22J023892 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.8 +38.5 38486 4.7 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B E2F8 ZNF416 GC22M026481 GC22M026483 GC22M026488 GC22M026493 GC22M026495 GC22M026496 GC22M026505 GC22M026506 GC22M026508 GC22M026511
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC2A11 gene promoter:
  • Elk-1
  • HTF
  • RFX1
  • En-1
  • p300
  • NF-1
  • Lmo2

Genomic Locations for SLC2A11 Gene

Genomic Locations for SLC2A11 Gene
29,607 bases
Plus strand
29,607 bases
Plus strand

Genomic View for SLC2A11 Gene

Genes around SLC2A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A11 Gene

Proteins for SLC2A11 Gene

  • Protein details for SLC2A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 11
    Protein Accession:
    Secondary Accessions:
    • E9PH55
    • Q542Y4
    • Q6ICJ5
    • Q8WXF9
    • Q8WYM4

    Protein attributes for SLC2A11 Gene

    496 amino acids
    Molecular mass:
    53703 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A11 Gene


neXtProt entry for SLC2A11 Gene

Post-translational modifications for SLC2A11 Gene

  • Glycosylation at posLast=4747
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A11 Gene

Domains & Families for SLC2A11 Gene

Gene Families for SLC2A11 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A11: view

Function for SLC2A11 Gene

Molecular function for SLC2A11 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter.

Gene Ontology (GO) - Molecular Function for SLC2A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
GO:0051119 sugar transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A11: view
genes like me logo Genes that share phenotypes with SLC2A11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A11 Gene

Localization for SLC2A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A11 gene
Compartment Confidence
plasma membrane 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC2A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with SLC2A11: view

Pathways & Interactions for SLC2A11 Gene

genes like me logo Genes that share pathways with SLC2A11: view

Interacting Proteins for SLC2A11 Gene

Gene Ontology (GO) - Biological Process for SLC2A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transmembrane transport TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC2A11: view

No data available for SIGNOR curated interactions for SLC2A11 Gene

Drugs & Compounds for SLC2A11 Gene

(4) Drugs for SLC2A11 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucose Approved, Vet_approved Pharma Transporter, substrate 0
D-glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved, Investigational Pharma Transporter, substrate 0
genes like me logo Genes that share compounds with SLC2A11: view

Transcripts for SLC2A11 Gene

mRNA/cDNA for SLC2A11 Gene

Unigene Clusters for SLC2A11 Gene

Solute carrier family 2 (facilitated glucose transporter), member 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - - -
SP10: - - - -
SP11: -
SP12: -

ExUns: 15d

Relevant External Links for SLC2A11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC2A11 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A11 Gene

Protein tissue co-expression partners for SLC2A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC2A11 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A11 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A11 Gene:

Tissue specificity: Expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for SLC2A11 Gene

  • Heart(4.2)
  • Nervous system(4.2)
  • Kidney(3)
  • Lung(2.5)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with SLC2A11: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A11 Gene

Orthologs for SLC2A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC2A11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A11 34 33
  • 97.18 (n)
(Canis familiaris)
Mammalia SLC2A11 34 33
  • 84.03 (n)
(Bos Taurus)
Mammalia SLC2A11 34 33
  • 84.01 (n)
(Gallus gallus)
Aves SLC2A11 33
  • 67.62 (n)
-- 34
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a11 33
  • 62.95 (n)
(Danio rerio)
Actinopterygii LOC560358 33
  • 59.3 (n)
slc2a11b 34
  • 46 (a)
Species where no ortholog for SLC2A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A11 Gene

Gene Tree for SLC2A11 (if available)
Gene Tree for SLC2A11 (if available)
Evolutionary constrained regions (ECRs) for SLC2A11: view image

Paralogs for SLC2A11 Gene

Paralogs for SLC2A11 Gene

(10) SIMAP similar genes for SLC2A11 Gene using alignment to 13 proteins:

  • F8WB79_HUMAN
  • Q496K8_HUMAN
  • Q496L1_HUMAN
  • Q504W2_HUMAN
  • Q6P4C1_HUMAN
  • Q6PJ99_HUMAN
genes like me logo Genes that share paralogs with SLC2A11: view

Variants for SLC2A11 Gene

Sequence variations from dbSNP and Humsavar for SLC2A11 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000011946 -- 23,871,603(+) A/C/G intron_variant
rs1000094916 -- 23,858,295(+) G/T intron_variant
rs1000246526 -- 23,864,619(+) A/G intron_variant
rs1000274473 -- 23,884,362(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000338510 -- 23,866,791(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A11 Gene

Variant ID Type Subtype PubMed ID
dgv1298e212 CNV loss 25503493
dgv1300e212 CNV gain 25503493
dgv1301e212 CNV gain 25503493
dgv4528n100 CNV gain 25217958
dgv4531n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv1010693 CNV deletion 20482838
esv2661391 CNV deletion 23128226
esv2724041 CNV deletion 23290073
esv2724065 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3575444 CNV gain 25503493
esv3575445 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv1143028 CNV tandem duplication 24896259
nsv3577 CNV insertion 18451855
nsv511075 OTHER complex 20534489
nsv526567 CNV gain 19592680
nsv588647 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv834155 CNV gain+loss 17160897

Variation tolerance for SLC2A11 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A11 Gene

Disorders for SLC2A11 Gene

Additional Disease Information for SLC2A11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC2A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A11 Gene

Publications for SLC2A11 Gene

  1. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PMID: 11741323) Sasaki T … Shimizu N (Biochemical and biophysical research communications 2001) 3 4 22 58
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  5. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PMID: 16154905) Scheepers A … Schürmann A (Molecular membrane biology 2005) 3 22 58

Products for SLC2A11 Gene

Sources for SLC2A11 Gene

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