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Aliases for TRAK2 Gene

Aliases for TRAK2 Gene

  • Trafficking Kinesin Protein 2 2 3 5
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 3 2 3
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 98 2 3
  • Gamma-Aminobutyric Acid(A) Receptor-Interacting Factor 2 3
  • Trafficking Protein, Kinesin Binding 2 2 3
  • ALS2CR3 3 4
  • Trafficking Kinesin-Binding Protein 2 3
  • Milton Homolog 2 (Drosophila) 2
  • Milton Homolog 2 3
  • KIAA0549 4
  • CALS-C 3
  • GRIF-1 3
  • GRIF1 3
  • MILT2 3
  • OIP98 3

External Ids for TRAK2 Gene

Previous HGNC Symbols for TRAK2 Gene

  • ALS2CR3

Previous GeneCards Identifiers for TRAK2 Gene

  • GC02M202068
  • GC02M201950
  • GC02M202241
  • GC02M194090

Summaries for TRAK2 Gene

GeneCards Summary for TRAK2 Gene

TRAK2 (Trafficking Kinesin Protein 2) is a Protein Coding gene. Diseases associated with TRAK2 include Amyotrophic Lateral Sclerosis 2, Juvenile and Juvenile Amyotrophic Lateral Sclerosis. Among its related pathways are Metabolism and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and GABA receptor binding. An important paralog of this gene is TRAK1.

UniProtKB/Swiss-Prot for TRAK2 Gene

  • May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Gene Wiki entry for TRAK2 Gene

Additional gene information for TRAK2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK2 Gene

Genomics for TRAK2 Gene

GeneHancer (GH) Regulatory Elements for TRAK2 Gene

Promoters and enhancers for TRAK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J201450 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.6 -585 3.4 HDGF SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 STRADB TRAK2 CASP8 TMEM237 C2CD6 ENO1P4 ALS2CR12 GC02P201507
GH02J201404 Enhancer 1.1 Ensembl ENCODE 11.5 +45.9 45898 2.7 ARNT BRCA1 ATF7 RUNX3 RXRA REST ZNF592 KAT8 NFIL3 ATF4 CASP8 PPIL3 TRAK2 ALS2CR12 RNU6-651P TMEM237 LOC100420110 STRADB
GH02J201403 Enhancer 0.7 Ensembl 11.5 +47.7 47695 0.2 NFIB GTF2E2 INSM2 CEBPG FEZF1 ZNF366 KLF8 SOX6 ZNF10 GTF2A2 TRAK2 ALS2CR12 CASP8 RNU6-651P TMEM237 LOC100420110 STRADB
GH02J201269 Enhancer 0.7 dbSUPER 11 +180.0 180046 5 HDGF ESRRA ZSCAN4 TSC22D4 CEBPG E4F1 ZNF121 POLR2B ZNF207 ATF7 CASP8 NOP58 STRADB ORC2 CLK1 ALS2CR12 TRAK2 LOC100420110 ENO1P4 C2CD6
GH02J201277 Enhancer 0.6 dbSUPER 10.4 +171.9 171892 3.6 ZNF512 NR2F1 IKZF1 CEBPB CEBPG ATF2 MAFK PRDM1 SPI1 CASP8 STRADB PPIL3 ALS2CR12 TRAK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAK2 gene promoter:
  • Tal-1beta
  • ITF-2
  • Bach2
  • RSRFC4
  • LyF-1
  • POU2F1
  • POU2F1a
  • Lhx3a
  • LHX3b
  • CUTL1

Genomic Locations for TRAK2 Gene

Genomic Locations for TRAK2 Gene
chr2:201,377,207-201,451,596
(GRCh38/hg38)
Size:
74,390 bases
Orientation:
Minus strand
chr2:202,241,930-202,316,319
(GRCh37/hg19)
Size:
74,390 bases
Orientation:
Minus strand

Genomic View for TRAK2 Gene

Genes around TRAK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK2 Gene

Proteins for TRAK2 Gene

  • Protein details for TRAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60296-TRAK2_HUMAN
    Recommended name:
    Trafficking kinesin-binding protein 2
    Protein Accession:
    O60296
    Secondary Accessions:
    • E7EV21
    • Q8WVH7
    • Q96NS2
    • Q9C0K5
    • Q9C0K6

    Protein attributes for TRAK2 Gene

    Size:
    914 amino acids
    Molecular mass:
    101419 Da
    Quaternary structure:
    • Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS (By similarity). Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.

    Alternative splice isoforms for TRAK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAK2 Gene

Post-translational modifications for TRAK2 Gene

Other Protein References for TRAK2 Gene

No data available for DME Specific Peptides for TRAK2 Gene

Domains & Families for TRAK2 Gene

Gene Families for TRAK2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRAK2 Gene

Suggested Antigen Peptide Sequences for TRAK2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAK2: view

No data available for UniProtKB/Swiss-Prot for TRAK2 Gene

Function for TRAK2 Gene

Molecular function for TRAK2 Gene

UniProtKB/Swiss-Prot Function:
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Phenotypes From GWAS Catalog for TRAK2 Gene

Gene Ontology (GO) - Molecular Function for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding ISS 12034717
GO:0005515 protein binding IPI 15644324
GO:0017022 myosin binding IBA --
GO:0019894 kinesin binding IEA --
GO:0019899 enzyme binding IEA --
genes like me logo Genes that share ontologies with TRAK2: view
genes like me logo Genes that share phenotypes with TRAK2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAK2 Gene

Localization for TRAK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK2 Gene

Cytoplasm. Early endosome. Mitochondrion. Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAK2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
nucleus 3
cytosol 3
endosome 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS 12034717
GO:0005739 mitochondrion ISS --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with TRAK2: view

Pathways & Interactions for TRAK2 Gene

SuperPathways for TRAK2 Gene

SuperPathway Contained pathways
1 GABAergic synapse
2 Metabolism
genes like me logo Genes that share pathways with TRAK2: view

Pathways by source for TRAK2 Gene

2 KEGG pathways for TRAK2 Gene

Gene Ontology (GO) - Biological Process for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006493 protein O-linked glycosylation IEA --
GO:0006605 protein targeting IEA --
GO:0008089 anterograde axonal transport IBA --
GO:0008104 protein localization IBA --
genes like me logo Genes that share ontologies with TRAK2: view

No data available for SIGNOR curated interactions for TRAK2 Gene

Drugs & Compounds for TRAK2 Gene

(1) Drugs for TRAK2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TRAK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAK2: view

Transcripts for TRAK2 Gene

mRNA/cDNA for TRAK2 Gene

Unigene Clusters for TRAK2 Gene

Trafficking protein, kinesin binding 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:

ExUns: 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TRAK2 Gene

GeneLoc Exon Structure for
TRAK2
ECgene alternative splicing isoforms for
TRAK2

Expression for TRAK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAK2 Gene

mRNA differential expression in normal tissues according to GTEx for TRAK2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.9).

Protein differential expression in normal tissues from HIPED for TRAK2 Gene

This gene is overexpressed in Neutrophil (32.5), Plasma (12.3), Blymphocyte (10.3), and Monocytes (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAK2 Gene



Protein tissue co-expression partners for TRAK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAK2 Gene:

TRAK2

SOURCE GeneReport for Unigene cluster for TRAK2 Gene:

Hs.152774

mRNA Expression by UniProt/SwissProt for TRAK2 Gene:

O60296-TRAK2_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart.

Evidence on tissue expression from TISSUES for TRAK2 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Liver(4.3)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with TRAK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAK2 Gene

Orthologs for TRAK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAK2 34 33
  • 99.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRAK2 34 33
  • 91.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRAK2 34 33
  • 89.77 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trak2 16 34 33
  • 85.45 (n)
rat
(Rattus norvegicus)
Mammalia Trak2 33
  • 84.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAK2 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAK2 34 33
  • 73.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAK2 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trak2 33
  • 63.21 (n)
zebrafish
(Danio rerio)
Actinopterygii trak2 34 33
  • 59.47 (n)
OneToOne
wufj21g01 33
fruit fly
(Drosophila melanogaster)
Insecta milt 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T27A3.1 34
  • 21 (a)
OneToMany
Species where no ortholog for TRAK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK2 Gene

ENSEMBL:
Gene Tree for TRAK2 (if available)
TreeFam:
Gene Tree for TRAK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAK2: view image

Paralogs for TRAK2 Gene

Paralogs for TRAK2 Gene

(3) SIMAP similar genes for TRAK2 Gene using alignment to 2 proteins:

  • TRAK2_HUMAN
  • Q8IU62_HUMAN

Pseudogenes.org Pseudogenes for TRAK2 Gene

genes like me logo Genes that share paralogs with TRAK2: view

Variants for TRAK2 Gene

Sequence variations from dbSNP and Humsavar for TRAK2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000025372 -- 201,450,448(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000050642 -- 201,435,238(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000114899 -- 201,395,077(-) T/C intron_variant
rs1000195905 -- 201,431,760(-) T/A intron_variant
rs1000206895 -- 201,406,710(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAK2 Gene

Variant ID Type Subtype PubMed ID
esv1007085 CNV insertion 20482838
esv28629 CNV loss 19812545
esv3303509 CNV mobile element insertion 20981092
esv3308284 CNV mobile element insertion 20981092
esv3357080 CNV insertion 20981092
esv3380819 CNV insertion 20981092
esv3575325 CNV gain 25503493
esv3593979 CNV loss 21293372
nsv961548 CNV duplication 23825009

Variation tolerance for TRAK2 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.94; 79.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAK2 Gene

Human Gene Mutation Database (HGMD)
TRAK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAK2 Gene

Disorders for TRAK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAK2 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 2, juvenile
  • als2
juvenile amyotrophic lateral sclerosis
  • amyotrophic lateral sclerosis, juvenile
- elite association - COSMIC cancer census association via MalaCards
Search TRAK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRAK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAK2 Gene

Publications for TRAK2 Gene

  1. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S … Aspenström P (Biochemical and biophysical research communications 2006) 3 4 22 58
  2. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PMID: 11161814) Hadano S … Hayden MR (Genomics 2001) 2 3 4 58
  3. Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. (PMID: 20230862) Koutsopoulos OS … Ryan MT (Biochimica et biophysica acta 2010) 2 3 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. (PMID: 16380713) Gilbert SL … Lahn BT (Nature genetics 2006) 2 3 58

Products for TRAK2 Gene

Sources for TRAK2 Gene

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