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Aliases for RASL11B Gene

Aliases for RASL11B Gene

  • RAS Like Family 11 Member B 2 3 5
  • Ras-Like Protein Family Member 11B 3
  • RAS-Like, Family 11, Member B 2
  • RAS-Like Family 11 Member B 2

External Ids for RASL11B Gene

Previous GeneCards Identifiers for RASL11B Gene

  • GC00U914304
  • GC04P053645
  • GC04P053569
  • GC04P053423
  • GC04P053728
  • GC04P049672

Summaries for RASL11B Gene

Entrez Gene Summary for RASL11B Gene

  • RASL11B is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

GeneCards Summary for RASL11B Gene

RASL11B (RAS Like Family 11 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and ferrous iron transmembrane transporter activity. An important paralog of this gene is RASL11A.

Gene Wiki entry for RASL11B Gene

Additional gene information for RASL11B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL11B Gene

Genomics for RASL11B Gene

GeneHancer (GH) Regulatory Elements for RASL11B Gene

Promoters and enhancers for RASL11B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J052862 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 655.7 +0.5 508 2 ATF1 RB1 KLF17 SIN3A ETS1 ZNF335 GLIS2 EGR1 ZNF143 ATF7 RASL11B PIR51358 DANCR GC04M052884
GH04J052861 Enhancer 0.4 ENCODE 650.7 -0.7 -741 0.2 SIN3A KLF4 PIR51358 RASL11B GC04M052856
GH04J052822 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.8 -37.8 -37795 3.8 ELF3 MEIS2 SOX13 SAP130 RARA TEAD3 FOSL1 POLR2A RCOR1 FOSL2 ERVMER34-1 ENSG00000212490 RASL11B DANCR GC04P052827 LINC01618
GH04J052721 Enhancer 1.1 Ensembl ENCODE 10.1 -139.8 -139792 1.8 HDGF PKNOX1 SIN3A BRCA1 YY1 GLIS2 ZNF143 KLF7 FOS RUNX3 ENSG00000248375 FIP1L1 ENSG00000212490 ERVMER34-1 USP46 RASL11B GC04P052749
GH04J052911 Enhancer 0.8 Ensembl ENCODE 10.2 +49.6 49611 0.2 CTCF RFX1 REST ELF1 ZNF644 RAD21 GABPA XRCC5 ZNF143 ZNF444 RASL11B LOC101928658 GC04M052884 SCFD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASL11B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASL11B gene promoter:
  • MAZR
  • TBP
  • AP-1
  • FOXO4
  • Hlf
  • AML1a
  • c-Myb
  • Sox9
  • HFH-1
  • Pax-2b

Genomic Locations for RASL11B Gene

Genomic Locations for RASL11B Gene
chr4:52,862,290-52,866,835
(GRCh38/hg38)
Size:
4,546 bases
Orientation:
Plus strand
chr4:53,728,457-53,733,002
(GRCh37/hg19)
Size:
4,546 bases
Orientation:
Plus strand

Genomic View for RASL11B Gene

Genes around RASL11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL11B Gene

Proteins for RASL11B Gene

  • Protein details for RASL11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPW5-RSLBB_HUMAN
    Recommended name:
    Ras-like protein family member 11B
    Protein Accession:
    Q9BPW5
    Secondary Accessions:
    • B2RC51
    • Q96KC5

    Protein attributes for RASL11B Gene

    Size:
    248 amino acids
    Molecular mass:
    27508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASL11B Gene

Post-translational modifications for RASL11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL11B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RASL11B
  • Boster Bio Antibodies for RASL11B
  • Santa Cruz Biotechnology (SCBT) Antibodies for RASL11B

No data available for DME Specific Peptides for RASL11B Gene

Domains & Families for RASL11B Gene

Gene Families for RASL11B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RASL11B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BPW5

UniProtKB/Swiss-Prot:

RSLBB_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL11B: view

Function for RASL11B Gene

Molecular function for RASL11B Gene

UniProtKB/Swiss-Prot Induction:
By TGFB1.

Gene Ontology (GO) - Molecular Function for RASL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005160 transforming growth factor beta receptor binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL11B: view
genes like me logo Genes that share phenotypes with RASL11B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL11B Gene

Localization for RASL11B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL11B gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL11B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASL11B Gene

Pathways & Interactions for RASL11B Gene

SuperPathways for RASL11B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RASL11B: view

No data available for Pathways by source and SIGNOR curated interactions for RASL11B Gene

Drugs & Compounds for RASL11B Gene

No Compound Related Data Available

Transcripts for RASL11B Gene

mRNA/cDNA for RASL11B Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASL11B Gene

RAS-like, family 11, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL11B Gene

No ASD Table

Relevant External Links for RASL11B Gene

GeneLoc Exon Structure for
RASL11B
ECgene alternative splicing isoforms for
RASL11B

Expression for RASL11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASL11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL11B Gene

This gene is overexpressed in Ovary (x11.2) and Spleen (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of RASL11B Gene:

RASL11B

SOURCE GeneReport for Unigene cluster for RASL11B Gene:

Hs.8035

mRNA Expression by UniProt/SwissProt for RASL11B Gene:

Q9BPW5-RSLBB_HUMAN
Tissue specificity: Widely expressed with highest levels in placenta and primary macrophages.

Evidence on tissue expression from TISSUES for RASL11B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RASL11B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL11B Gene

Orthologs for RASL11B Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL11B 34 33
  • 99.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RASL11B 34 33
  • 89.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RASL11B 34 33
  • 89.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASL11B 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasl11b 33
  • 87.58 (n)
mouse
(Mus musculus)
Mammalia Rasl11b 16 34 33
  • 86.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASL11B 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASL11B 34 33
  • 78.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASL11B 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl11b 33
  • 72.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53580 33
zebrafish
(Danio rerio)
Actinopterygii rasl11b 34 33
  • 66.1 (n)
OneToOne
zgc55750 33
fruit fly
(Drosophila melanogaster)
Insecta CG8519 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for RASL11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL11B Gene

ENSEMBL:
Gene Tree for RASL11B (if available)
TreeFam:
Gene Tree for RASL11B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASL11B: view image

Paralogs for RASL11B Gene

Paralogs for RASL11B Gene

(20) SIMAP similar genes for RASL11B Gene using alignment to 2 proteins:

  • RSLBB_HUMAN
  • A0PHL1_HUMAN
genes like me logo Genes that share paralogs with RASL11B: view

Variants for RASL11B Gene

Sequence variations from dbSNP and Humsavar for RASL11B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000144761 -- 52,862,193(+) G/C upstream_transcript_variant
rs1000512547 -- 52,864,301(+) G/A intron_variant
rs1000515006 -- 52,862,230(+) G/A upstream_transcript_variant
rs1001113898 -- 52,861,630(+) C/G upstream_transcript_variant
rs1001172840 -- 52,862,124(+) T/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RASL11B Gene

Variant ID Type Subtype PubMed ID
dgv1000e214 CNV loss 21293372
nsv594201 CNV loss 21841781

Variation tolerance for RASL11B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASL11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASL11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL11B Gene

Disorders for RASL11B Gene

Additional Disease Information for RASL11B

No disorders were found for RASL11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL11B Gene

Publications for RASL11B Gene

  1. Cloning, genomic organization, and tissue-specific expression of the RASL11B gene. (PMID: 17628721) Stolle K … Lorkowski S (Biochimica et biophysica acta 2007) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. (PMID: 15033445) Louro R … Reis EM (Biochemical and biophysical research communications 2004) 3 4 58
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for RASL11B Gene

Sources for RASL11B Gene

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