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Aliases for SLC22A3 Gene

Aliases for SLC22A3 Gene

  • Solute Carrier Family 22 Member 3 2 3 5
  • Extraneuronal Monoamine Transporter 2 3 4
  • Organic Cation Transporter 3 2 3 4
  • Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 3 2 3
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 3 2 3
  • OCT3 3 4
  • EMTH 3 4
  • EMT 3 4
  • EMT Organic Cation Transporter 3 3

External Ids for SLC22A3 Gene

Previous GeneCards Identifiers for SLC22A3 Gene

  • GC06P160208
  • GC06P160642
  • GC06P160678
  • GC06P160739
  • GC06P158244

Summaries for SLC22A3 Gene

Entrez Gene Summary for SLC22A3 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A3 Gene

SLC22A3 (Solute Carrier Family 22 Member 3) is a Protein Coding gene. Diseases associated with SLC22A3 include Extragonadal Seminoma and Cerebral Palsy, Ataxic, Autosomal Recessive. Among its related pathways are Metformin Pathway, Pharmacodynamics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and organic cation transmembrane transporter activity. An important paralog of this gene is SLC22A2.

UniProtKB/Swiss-Prot for SLC22A3 Gene

  • Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Gene Wiki entry for SLC22A3 Gene

Additional gene information for SLC22A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A3 Gene

Genomics for SLC22A3 Gene

GeneHancer (GH) Regulatory Elements for SLC22A3 Gene

Promoters and enhancers for SLC22A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I160347 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 557.2 +0.3 254 2.3 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 RXRA REST PPARG KAT8 SLC22A3 GC06P160403
GH06I160455 Enhancer 1 Ensembl ENCODE 25.8 +107.6 107569 1.7 ELF3 RB1 ARID4B ZNF48 ZSCAN9 RAD21 ARID2 SCRT2 ZNF143 RUNX3 SLC22A3 SNORA29 TCP1 PIR50129 LPAL2
GH06I160386 Enhancer 1 Ensembl ENCODE dbSUPER 22.8 +39.1 39070 1.7 CTCF PKNOX1 JUN MAX SIN3A REST RAD21 SP1 JUND ATF3 SLC22A3 GC06P160403
GH06I160237 Enhancer 1 Ensembl ENCODE 19.5 -109.0 -108985 4.3 PKNOX1 ATF1 ZBTB40 ZNF766 ATF7 ELK4 ZBTB11 CEBPB ELF1 HDAC8 PIR56125 SLC22A3 SLC22A2 LOC105378088
GH06I160390 Enhancer 1 ENCODE dbSUPER 19.2 +43.4 43422 1.7 FOXA2 JUN SIN3A ZNF644 FOSL1 FOSL2 FOS NFE2 MAFK CREM SLC22A3 GC06P160403
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC22A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC22A3 gene promoter:

Genomic Locations for SLC22A3 Gene

Genomic Locations for SLC22A3 Gene
chr6:160,348,268-160,452,581
(GRCh38/hg38)
Size:
104,314 bases
Orientation:
Plus strand
chr6:160,769,300-160,876,014
(GRCh37/hg19)

Genomic View for SLC22A3 Gene

Genes around SLC22A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A3 Gene

Proteins for SLC22A3 Gene

  • Protein details for SLC22A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75751-S22A3_HUMAN
    Recommended name:
    Solute carrier family 22 member 3
    Protein Accession:
    O75751
    Secondary Accessions:
    • Q5SYN6
    • Q9UP02

    Protein attributes for SLC22A3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A3 Gene

Post-translational modifications for SLC22A3 Gene

  • Glycosylation at posLast=7272, posLast=9999, isoforms=119, and posLast=322322
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A3 Gene

No data available for DME Specific Peptides for SLC22A3 Gene

Domains & Families for SLC22A3 Gene

Gene Families for SLC22A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

O75751

UniProtKB/Swiss-Prot:

S22A3_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A3: view

Function for SLC22A3 Gene

Molecular function for SLC22A3 Gene

GENATLAS Biochemistry:
solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2
UniProtKB/Swiss-Prot Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Phenotypes From GWAS Catalog for SLC22A3 Gene

Gene Ontology (GO) - Molecular Function for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005329 dopamine transmembrane transporter activity IBA,IEA --
GO:0005515 protein binding IPI 17474147
GO:0008514 organic anion transmembrane transporter activity IBA --
GO:0015101 organic cation transmembrane transporter activity IEA,TAS --
GO:0015651 quaternary ammonium group transmembrane transporter activity IDA,IEA 10966924
genes like me logo Genes that share ontologies with SLC22A3: view
genes like me logo Genes that share phenotypes with SLC22A3: view

Animal Models for SLC22A3 Gene

MGI Knock Outs for SLC22A3:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A3 Gene

Localization for SLC22A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9933568
GO:0016020 membrane TAS 9933568
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A3: view

Pathways & Interactions for SLC22A3 Gene

genes like me logo Genes that share pathways with SLC22A3: view

Gene Ontology (GO) - Biological Process for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006855 drug transmembrane transport TAS --
GO:0015695 organic cation transport IEA,IDA 10966924
GO:0015697 quaternary ammonium group transport IDA,IEA 10966924
genes like me logo Genes that share ontologies with SLC22A3: view

No data available for SIGNOR curated interactions for SLC22A3 Gene

Drugs & Compounds for SLC22A3 Gene

(48) Drugs for SLC22A3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desipramine Approved, Investigational Pharma Transporter, inhibitor 39
Dopamine Approved Pharma Full agonist, Agonist, Transporter, inhibitor 4008
Guanidine Approved Pharma Transporter, substrate, inhibitor 0
Norepinephrine Approved Pharma Transporter, substrate, inhibitor 737
Metformin Approved Pharma Transporter, substrate AMP-activated protein kinase (AMPK) activator 1891

(7) Additional Compounds for SLC22A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC22A3: view

Transcripts for SLC22A3 Gene

Unigene Clusters for SLC22A3 Gene

Solute carrier family 22 (extraneuronal monoamine transporter), member 3:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for SLC22A3 Gene

GeneLoc Exon Structure for
SLC22A3
ECgene alternative splicing isoforms for
SLC22A3

Expression for SLC22A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A3 Gene

This gene is overexpressed in Artery - Aorta (x6.5), Muscle - Skeletal (x6.0), Nerve - Tibial (x4.9), and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for SLC22A3 Gene

This gene is overexpressed in Seminal vesicle (19.6), Prostate (16.8), Liver (11.5), and Ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC22A3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC22A3 Gene:

SLC22A3

SOURCE GeneReport for Unigene cluster for SLC22A3 Gene:

Hs.567337

mRNA Expression by UniProt/SwissProt for SLC22A3 Gene:

O75751-S22A3_HUMAN
Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.

Evidence on tissue expression from TISSUES for SLC22A3 Gene

  • Kidney(4.4)
  • Liver(2.4)
  • Nervous system(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with SLC22A3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A3 Gene

Orthologs for SLC22A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A3 33 34
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia SLC22A3 33 34
  • 89.49 (n)
dog
(Canis familiaris)
Mammalia SLC22A3 33 34
  • 89.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A3 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a3 33
  • 85.48 (n)
mouse
(Mus musculus)
Mammalia Slc22a3 33 16 34
  • 85 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC22A3 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A3 33 34
  • 72.47 (n)
lizard
(Anolis carolinensis)
Reptilia SLC22A3 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:175176 33
  • 54.41 (n)
SLC22A3 34
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8654 35
  • 38 (a)
CG6600 35
  • 33 (a)
Orct 35
  • 31 (a)
CG13610 35
  • 30 (a)
CG9317 35
  • 30 (a)
CG3790 35
  • 29 (a)
CG6126 35
  • 29 (a)
CG4630 34
  • 29 (a)
ManyToMany
CG7442 35 34
  • 28 (a)
CG7458 35 34
  • 28 (a)
CG17751 35
  • 27 (a)
CG5592 35
  • 27 (a)
CG17752 35
  • 26 (a)
CG6231 35
  • 26 (a)
CG14857 35
  • 25 (a)
CG16727 35
  • 24 (a)
CG7084 35
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea F52F12.1a 35
  • 29 (a)
oct-1 35
  • 29 (a)
B0252.3 35
  • 27 (a)
K05F1.6 35
  • 27 (a)
Y82E9BR.16 35
  • 26 (a)
ZK455.8a 35
  • 26 (a)
ZK455.8b 35
  • 26 (a)
Species where no ortholog for SLC22A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A3 Gene

ENSEMBL:
Gene Tree for SLC22A3 (if available)
TreeFam:
Gene Tree for SLC22A3 (if available)

Paralogs for SLC22A3 Gene

Pseudogenes.org Pseudogenes for SLC22A3 Gene

genes like me logo Genes that share paralogs with SLC22A3: view

Variants for SLC22A3 Gene

Sequence variations from dbSNP and Humsavar for SLC22A3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000021601 -- 160,394,060(+) A/G intron_variant
rs1000026041 -- 160,432,442(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000036580 -- 160,400,164(+) T/C intron_variant
rs1000074634 -- 160,439,015(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000103551 -- 160,350,992(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A3 Gene

Variant ID Type Subtype PubMed ID
esv2759484 CNV gain+loss 17122850
esv35098 CNV gain 17911159
esv3611428 CNV gain 21293372
nsv1020357 CNV loss 25217958
nsv1026543 CNV gain 25217958
nsv818463 CNV gain 17921354
nsv969462 CNV duplication 23825009

Variation tolerance for SLC22A3 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A3 Gene

Human Gene Mutation Database (HGMD)
SLC22A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A3 Gene

Disorders for SLC22A3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC22A3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
extragonadal seminoma
  • primary extragonadal seminoma
cerebral palsy, ataxic, autosomal recessive
  • acp
type 1 diabetes mellitus 8
  • diabetes mellitus, insulin-dependent, 8
chromosome 3q29 deletion syndrome
  • microdeletion 3q29 syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC22A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A3 Gene

Publications for SLC22A3 Gene

  1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PMID: 10966924) Wu X … Ganapathy V (American journal of physiology. Renal physiology 2000) 3 4 22 25 58
  2. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. (PMID: 19591196) Nies AT … Schaeffeler E (Hepatology (Baltimore, Md.) 2009) 3 22 44 58
  3. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. (PMID: 17010131) Aoyama N … Ozaki N (Alcoholism, clinical and experimental research 2006) 3 22 44 58
  4. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PMID: 9933568) Verhaagh S … Zwart R (Genomics 1999) 2 3 4 58
  5. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. (PMID: 10196521) Gründemann D … Schömig E (Nature neuroscience 1998) 3 4 25 58

Products for SLC22A3 Gene

Sources for SLC22A3 Gene

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