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Aliases for SLC6A2 Gene

Aliases for SLC6A2 Gene

  • Solute Carrier Family 6 Member 2 2 3 4 5
  • Norepinephrine Transporter 2 3 4
  • Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 2 3
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 2 2 3
  • SLC6A5 3 4
  • NAT1 3 4
  • NET1 3 4
  • NET 3 4
  • Sodium-Dependent Noradrenaline Transporter 3
  • Solute Carrier Family 6 Member 5 3
  • Neurotransmitter Transporter 3

External Ids for SLC6A2 Gene

Previous HGNC Symbols for SLC6A2 Gene

  • NET1
  • NAT1
  • SLC6A5

Previous GeneCards Identifiers for SLC6A2 Gene

  • GC16M046129
  • GC16P055745
  • GC16P055428
  • GC16P055469
  • GC16P054247
  • GC16P041576

Summaries for SLC6A2 Gene

Entrez Gene Summary for SLC6A2 Gene

  • This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

GeneCards Summary for SLC6A2 Gene

SLC6A2 (Solute Carrier Family 6 Member 2) is a Protein Coding gene. Diseases associated with SLC6A2 include Orthostatic Intolerance and Syncope. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Monoamine Transport. Gene Ontology (GO) annotations related to this gene include beta-tubulin binding and neurotransmitter:sodium symporter activity. An important paralog of this gene is SLC6A3.

UniProtKB/Swiss-Prot for SLC6A2 Gene

  • Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Tocris Summary for SLC6A2 Gene

  • Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for re-uptake of adrenalin and noradrenalin.

Gene Wiki entry for SLC6A2 Gene

Additional gene information for SLC6A2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A2 Gene

Genomics for SLC6A2 Gene

GeneHancer (GH) Regulatory Elements for SLC6A2 Gene

Promoters and enhancers for SLC6A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I055658 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 +0.3 323 0.2 MAZ ZNF449 ZIC2 ZNF335 RCOR1 PRDM10 ZBTB26 EZH2 CHD2 SLC6A2 ENSG00000278928
GH16I055656 Promoter/Enhancer 0.9 EPDnew ENCODE 579.3 +1.0 966 0.2 ZNF335 SIN3A EZH2 SLC6A2 ENSG00000278928
GH16I055657 Enhancer 0.6 ENCODE 550.8 +0.6 600 0.2 CTCF MAZ USF1 ZNF449 SIN3A ZIC2 ZNF335 PRDM10 ZBTB26 EZH2 SLC6A2 ENSG00000278928
GH16I055655 Promoter 0.6 EPDnew 550.8 -0.1 -83 0.1 EZH2 SLC6A2 CAPNS2
GH16I055671 Promoter 0.6 EPDnew 550.4 +16.0 16021 0.1 NRF1 SLC6A2 MMP2 ENSG00000278928
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC6A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC6A2 gene promoter:

Genomic Locations for SLC6A2 Gene

Genomic Locations for SLC6A2 Gene
50,589 bases
Plus strand

Genomic View for SLC6A2 Gene

Genes around SLC6A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A2 Gene

Proteins for SLC6A2 Gene

  • Protein details for SLC6A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent noradrenaline transporter
    Protein Accession:
    Secondary Accessions:
    • B2R707
    • B4DX48
    • Q96KH8

    Protein attributes for SLC6A2 Gene

    617 amino acids
    Molecular mass:
    69332 Da
    Quaternary structure:
    • Interacts with PRKCABP.
    • This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

    Alternative splice isoforms for SLC6A2 Gene


neXtProt entry for SLC6A2 Gene

Post-translational modifications for SLC6A2 Gene

  • Glycosylation at posLast=184184, posLast=192192, and isoforms=2, 3198
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC6A2 Gene

Domains & Families for SLC6A2 Gene

Gene Families for SLC6A2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC6A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
genes like me logo Genes that share domains with SLC6A2: view

Function for SLC6A2 Gene

Molecular function for SLC6A2 Gene

GENATLAS Biochemistry:
solute carrier family 6,member 2,neurotransmitter transporter,noradrenalin/morepinephrine
UniProtKB/Swiss-Prot Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Phenotypes From GWAS Catalog for SLC6A2 Gene

Gene Ontology (GO) - Molecular Function for SLC6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005330 NOT dopamine:sodium symporter activity IBA --
GO:0005333 norepinephrine transmembrane transporter activity IEA,IBA --
GO:0005334 norepinephrine:sodium symporter activity TAS --
GO:0005515 protein binding IPI 11343649
GO:0008504 monoamine transmembrane transporter activity IDA 16024787
genes like me logo Genes that share ontologies with SLC6A2: view
genes like me logo Genes that share phenotypes with SLC6A2: view

Human Phenotype Ontology for SLC6A2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC6A2 Gene

MGI Knock Outs for SLC6A2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC6A2 Gene

Localization for SLC6A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC6A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 2008212
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC6A2: view

Pathways & Interactions for SLC6A2 Gene

genes like me logo Genes that share pathways with SLC6A2: view

Gene Ontology (GO) - Biological Process for SLC6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 2008212
GO:0006836 neurotransmitter transport IEA --
GO:0007268 chemical synaptic transmission TAS 2008212
GO:0015844 monoamine transport IDA 16024787
GO:0015874 norepinephrine transport IBA,IEA --
genes like me logo Genes that share ontologies with SLC6A2: view

No data available for SIGNOR curated interactions for SLC6A2 Gene

Drugs & Compounds for SLC6A2 Gene

(144) Drugs for SLC6A2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atomoxetine Approved Pharma Target, inhibitor 0
Methylphenidate Approved, Investigational Pharma Target, inhibitor, blocker 387
Venlafaxine Approved Pharma Target, inhibitor Dual serotonin/noradrenalin re-uptake inhibitor 0
Mazindol Approved, Investigational Pharma Inhibition, Inhibitor, Target, inhibitor 3
Reboxetine Approved, Investigational Pharma Inhibition, Inhibitor, Target, inhibitor 26

(40) Additional Compounds for SLC6A2 Gene - From: Novoseek, HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
Tomoxetine hydrochloride

(5) Tocris Compounds for SLC6A2 Gene

Compound Action Cas Number
Bicifadine hydrochloride Noradrenalin, 5-HT and dopamine re-uptake inhibitor 66504-75-4
Maprotiline hydrochloride Noradrenalin re-uptake inhibitor 10347-81-6
Nisoxetine hydrochloride Noradrenalin re-uptake inhibitor 57754-86-6
Reboxetine mesylate Potent, selective noradrenalin uptake inhibitor; orally active 98769-84-7
Tomoxetine hydrochloride Potent, selective noradrenalin re-uptake inhibitor 82248-59-7

(16) ApexBio Compounds for SLC6A2 Gene

Compound Action Cas Number
Atomoxetine HCl Noradrenalin re-uptake inhibitor 82248-59-7
Bicifadine hydrochloride 66504-75-4
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
CHC 28166-41-8
Desipramine hydrochloride 58-28-6
Indatraline hydrochloride 96850-13-4
Lofepramine 23047-25-8
Milnacipran HCl 101152-94-7
Mofegiline hydrochloride 120635-25-8
NBI-98782 85081-18-1
NBI-98854 171598-74-6
Nisoxetine hydrochloride 57754-86-6
Reboxetine mesylate 98769-84-7
Reserpine hydrochloride 16994-56-2
Talopram hydrochloride 7013-41-4
Talsupram hydrochloride 25487-28-9
genes like me logo Genes that share compounds with SLC6A2: view

Drug Products

Transcripts for SLC6A2 Gene

Unigene Clusters for SLC6A2 Gene

Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP2: - -
SP3: -
SP4: -

Relevant External Links for SLC6A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC6A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A2 Gene

This gene is overexpressed in Testis (x11.5), Skin - Not Sun Exposed (Suprapubic) (x6.3), Cervix - Endocervix (x5.2), and Adrenal Gland (x5.1).

Protein differential expression in normal tissues from HIPED for SLC6A2 Gene

This gene is overexpressed in Esophagus (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC6A2 Gene

Protein tissue co-expression partners for SLC6A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC6A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC6A2 Gene:


Evidence on tissue expression from TISSUES for SLC6A2 Gene

  • Lung(4)
  • Nervous system(3)
  • Adrenal gland(2.5)
  • Blood(2.1)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC6A2 Gene

Germ Layers:
  • mesoderm
  • cardiovascular
Head and neck:
  • ear
  • heart
  • heart valve
genes like me logo Genes that share expression patterns with SLC6A2: view

No data available for mRNA Expression by UniProt/SwissProt for SLC6A2 Gene

Orthologs for SLC6A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC6A2 33 34
  • 99.73 (n)
(Bos Taurus)
Mammalia SLC6A2 33 34
  • 90.19 (n)
(Canis familiaris)
Mammalia SLC6A2 33 34
  • 89.63 (n)
(Ornithorhynchus anatinus)
Mammalia SLC6A2 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Slc6a2 33
  • 87.19 (n)
(Mus musculus)
Mammalia Slc6a2 33 16 34
  • 86.6 (n)
(Monodelphis domestica)
Mammalia SLC6A2 34
  • 85 (a)
(Gallus gallus)
Aves SLC6A2 33 34
  • 76.11 (n)
(Anolis carolinensis)
Reptilia SLC6A2 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a2 33
  • 71.38 (n)
(Danio rerio)
Actinopterygii slc6a2 34
  • 70 (a)
LOC565776 33
  • 69.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007367 33
  • 62.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta DAT 35 33 34
  • 58.92 (n)
SerT 35
  • 54 (a)
ine 35
  • 39 (a)
CG3252 35
  • 37 (a)
CG1698 35
  • 36 (a)
CG10804 35
  • 35 (a)
CG4476 35
  • 35 (a)
CG8850 35
  • 35 (a)
BG:DS03431.1 35
  • 33 (a)
CG7075 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea dat-1 33 34
  • 53.58 (n)
mod-5 35
  • 46 (a)
snf-3 35
  • 38 (a)
snf-4 35
  • 32 (a)
snf-2 35
  • 31 (a)
snf-12 35
  • 29 (a)
snf-8 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10022 34
  • 38 (a)
Species where no ortholog for SLC6A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A2 Gene

Gene Tree for SLC6A2 (if available)
Gene Tree for SLC6A2 (if available)

Paralogs for SLC6A2 Gene

Variants for SLC6A2 Gene

Sequence variations from dbSNP and Humsavar for SLC6A2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs111663130 likely-benign, Orthostatic intolerance 55,702,952(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs113163898 uncertain-significance, Orthostatic intolerance 55,702,762(+) C/ 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs115138076 likely-benign, Orthostatic intolerance 55,702,717(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs11568323 uncertain-significance, Orthostatic intolerance 55,656,715(+) C/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs11568343 likely-benign, Orthostatic intolerance 55,671,926(+) G/A/C coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A2 Gene

Variant ID Type Subtype PubMed ID
dgv61e19 CNV gain 19470904
esv1621115 CNV insertion 17803354
esv2758649 CNV gain 17122850
esv3310496 CNV novel sequence insertion 20981092
esv3409715 CNV insertion 20981092
esv3440837 CNV insertion 20981092
esv3571298 CNV gain 25503493
esv3638684 CNV gain 21293372
nsv103423 CNV insertion 16902084
nsv1813 CNV insertion 18451855
nsv478556 CNV novel sequence insertion 20440878
nsv517827 CNV loss 19592680
nsv572631 CNV loss 21841781
nsv819933 CNV gain 19587683

Variation tolerance for SLC6A2 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC6A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A2 Gene

Disorders for SLC6A2 Gene

MalaCards: The human disease database

(25) MalaCards diseases for SLC6A2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
orthostatic intolerance
  • floppy mitral valve
oppositional defiant disorder
ocular hyperemia
  • hyperemia eye
generalized anxiety disorder
  • anxiety generalized
- elite association - COSMIC cancer census association via MalaCards


  • Orthostatic intolerance (OI) [MIM:604715]: Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. {ECO:0000269 PubMed:10684912}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLC6A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC6A2: view

No data available for Genatlas for SLC6A2 Gene

Publications for SLC6A2 Gene

  1. Norepinephrine transporter gene variation modulates acute response to D-amphetamine. (PMID: 17239355) Dlugos A … de Wit H (Biological psychiatry 2007) 3 22 25 44 58
  2. Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes. (PMID: 17124432) Ksiazek P … Buraczynska M (Kidney & blood pressure research 2006) 3 22 25 44 58
  3. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. (PMID: 19844206) Dong C … Licinio J (Molecular psychiatry 2009) 3 22 44 58
  4. Further evidence of association between amphetamine response and SLC6A2 gene variants. (PMID: 19727679) Dlugos AM … de Wit H (Psychopharmacology 2009) 3 25 44 58
  5. Novel and functional norepinephrine transporter protein variants identified in attention-deficit hyperactivity disorder. (PMID: 19698724) Hahn MK … Krueger JJ (Neuropharmacology 2009) 3 22 44 58

Products for SLC6A2 Gene

Sources for SLC6A2 Gene

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