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Aliases for SLC5A2 Gene

Aliases for SLC5A2 Gene

  • Solute Carrier Family 5 Member 2 2 3 4 5
  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 2 2 3
  • Low Affinity Sodium-Glucose Cotransporter 3 4
  • Na(+)/Glucose Cotransporter 2 3 4
  • SGLT2 3 4
  • Solute Carrier Family 5 (Sodium/Glucose Transporter), Member 2 3
  • Sodium/Glucose Cotransporter 2 3

External Ids for SLC5A2 Gene

Previous HGNC Symbols for SLC5A2 Gene

  • SGLT2

Previous GeneCards Identifiers for SLC5A2 Gene

  • GC16P030575
  • GC16P031991
  • GC16P031491
  • GC16P031530
  • GC16P031403
  • GC16P029054

Summaries for SLC5A2 Gene

Entrez Gene Summary for SLC5A2 Gene

  • This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]

GeneCards Summary for SLC5A2 Gene

SLC5A2 (Solute Carrier Family 5 Member 2) is a Protein Coding gene. Diseases associated with SLC5A2 include Renal Glucosuria and Aminoaciduria. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and low-affinity glucose:sodium symporter activity. An important paralog of this gene is SLC5A1.

UniProtKB/Swiss-Prot for SLC5A2 Gene

  • Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.

  • Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

Gene Wiki entry for SLC5A2 Gene

Additional gene information for SLC5A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A2 Gene

Genomics for SLC5A2 Gene

GeneHancer (GH) Regulatory Elements for SLC5A2 Gene

Promoters and enhancers for SLC5A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J031480 Enhancer 0.7 ENCODE 650.7 -1.4 -1410 1.2 HDAC1 MEIS2 PKNOX1 CTBP1 L3MBTL2 BHLHE40 CBFA2T3 MNT NR2F2 NFIC SLC5A2 ENSG00000260740 ENSG00000280132
GH16J031483 Promoter 0.5 EPDnew 650.7 +0.6 569 0.1 SLC5A2 ENSG00000260740
GH16J031522 Promoter 0.5 EPDnew 11.4 +39.8 39846 0.1 GC16P031521 C16orf58 SLC5A2 TGFB1I1 CLUHP3 ZNF720 ARMC5 AHSP
GH16J031484 Enhancer 1.1 Ensembl ENCODE 0.7 +2.3 2276 1.7 ELF3 MLX ZSCAN4 ARID4B DMAP1 RAD21 RARA ZNF614 THAP11 MIXL1 ENSG00000260740 ZNF843 ITGAD SLC5A2
GH16J031470 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 0.4 -9.6 -9584 4.8 HDGF SIN3A YY1 ZNF121 GLIS2 GATA2 ZNF143 SP3 NFYC ZHX2 ENSG00000280132 TGFB1I1 ENSG00000260740 HERC2P4 SLC5A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC5A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC5A2 gene promoter:
  • HNF-4alpha1
  • HNF-4alpha2
  • COUP-TF1
  • COUP
  • Sp1

Genomic Locations for SLC5A2 Gene

Genomic Locations for SLC5A2 Gene
8,326 bases
Plus strand
7,859 bases
Plus strand

Genomic View for SLC5A2 Gene

Genes around SLC5A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC5A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC5A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A2 Gene

Proteins for SLC5A2 Gene

  • Protein details for SLC5A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/glucose cotransporter 2
    Protein Accession:
    Secondary Accessions:
    • A2RRD2

    Protein attributes for SLC5A2 Gene

    672 amino acids
    Molecular mass:
    72897 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC5A2 Gene


neXtProt entry for SLC5A2 Gene

Post-translational modifications for SLC5A2 Gene

  • Glycosylation at isoforms=399 and posLast=250250
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC5A2 Gene

No data available for DME Specific Peptides for SLC5A2 Gene

Domains & Families for SLC5A2 Gene

Gene Families for SLC5A2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC5A2 Gene

Suggested Antigen Peptide Sequences for SLC5A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A2: view

Function for SLC5A2 Gene

Molecular function for SLC5A2 Gene

UniProtKB/Swiss-Prot Function:
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.
UniProtKB/Swiss-Prot Function:
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
GENATLAS Biochemistry:
solute carrier family 5 (sodium/glucose cotransporter),member 2

Gene Ontology (GO) - Molecular Function for SLC5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005362 low-affinity glucose:sodium symporter activity TAS 8244402
GO:0005412 glucose:sodium symporter activity TAS --
GO:0015293 symporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A2: view
genes like me logo Genes that share phenotypes with SLC5A2: view

Human Phenotype Ontology for SLC5A2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC5A2 Gene

MGI Knock Outs for SLC5A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC5A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for SLC5A2 Gene

Localization for SLC5A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC5A2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 8244402
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SLC5A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC5A2 Gene

Pathways & Interactions for SLC5A2 Gene

genes like me logo Genes that share pathways with SLC5A2: view

Pathways by source for SLC5A2 Gene

1 BioSystems pathway for SLC5A2 Gene
1 Cell Signaling Technology pathway for SLC5A2 Gene

Interacting Proteins for SLC5A2 Gene

Gene Ontology (GO) - Biological Process for SLC5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 8244402
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC5A2: view

No data available for SIGNOR curated interactions for SLC5A2 Gene

Drugs & Compounds for SLC5A2 Gene

(21) Drugs for SLC5A2 Gene - From: DrugBank, ClinicalTrials, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Canagliflozin Approved Pharma Inhibition, Inhibitor, blocker, Target, inhibitor SGLT2 inhibitor,potent and selective 116
Dapagliflozin Approved Pharma Inhibition, Inhibitor, blocker, Target, antagonist, inhibitor SGLT2 inhibitor,potent and selective 0
Empagliflozin Approved Pharma Inhibition, Inhibitor, Target, antagonist, inhibitor 150
D-glucose Approved, Vet_approved Pharma Transporter, substrate 0
Ertugliflozin Approved, Investigational Pharma Target, antagonist 0

(2) Additional Compounds for SLC5A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Na(+)
  • Na+
  • SODIUM ion
genes like me logo Genes that share compounds with SLC5A2: view

Transcripts for SLC5A2 Gene

mRNA/cDNA for SLC5A2 Gene

Unigene Clusters for SLC5A2 Gene

Solute carrier family 5 (sodium/glucose cotransporter), member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - -
SP2: - -
SP3: -
SP4: - -
SP6: - -

Relevant External Links for SLC5A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC5A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC5A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC5A2 Gene

This gene is overexpressed in Kidney - Cortex (x36.9) and Testis (x8.1).

Protein differential expression in normal tissues from HIPED for SLC5A2 Gene

This gene is overexpressed in Urine (58.3) and Kidney (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC5A2 Gene

Protein tissue co-expression partners for SLC5A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC5A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC5A2 Gene:


Evidence on tissue expression from TISSUES for SLC5A2 Gene

  • Kidney(4.7)
  • Blood(2.5)
  • Urine(2.5)
  • Liver(2.3)
  • Pancreas(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC5A2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • nervous
  • urinary
Head and neck:
  • brain
  • head
  • pituitary gland
  • kidney
genes like me logo Genes that share expression patterns with SLC5A2: view

No data available for mRNA Expression by UniProt/SwissProt for SLC5A2 Gene

Orthologs for SLC5A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC5A2 34 33
  • 99.6 (n)
(Bos Taurus)
Mammalia SLC5A2 34 33
  • 88.69 (n)
(Canis familiaris)
Mammalia SLC5A2 34 33
  • 87.75 (n)
(Monodelphis domestica)
Mammalia SLC5A2 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Slc5a2 33
  • 85 (n)
(Mus musculus)
Mammalia Slc5a2 16 34 33
  • 84.75 (n)
(Anolis carolinensis)
Reptilia SLC5A2 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc5a2 33
  • 68.96 (n)
Str.4321 33
(Danio rerio)
Actinopterygii slc5a2 34 33
  • 63.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.349 34
  • 52 (a)
-- 34
  • 51 (a)
-- 34
  • 48 (a)
Species where no ortholog for SLC5A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC5A2 Gene

Gene Tree for SLC5A2 (if available)
Gene Tree for SLC5A2 (if available)
Evolutionary constrained regions (ECRs) for SLC5A2: view image

Paralogs for SLC5A2 Gene

(6) SIMAP similar genes for SLC5A2 Gene using alignment to 4 proteins:

  • H3BP44_HUMAN
  • Q8WY15_HUMAN
genes like me logo Genes that share paralogs with SLC5A2: view

Variants for SLC5A2 Gene

Sequence variations from dbSNP and Humsavar for SLC5A2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs114517938 uncertain-significance, Familial renal glucosuria 31,490,598(+) G/A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs121918621 pathogenic, Familial renal glucosuria 31,488,919(+) G/A coding_sequence_variant, intron_variant, stop_gained
rs138795531 uncertain-significance, Familial renal glucosuria 31,487,578(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs138803748 uncertain-significance, Familial renal glucosuria 31,486,269(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs141627694 uncertain-significance, Familial renal glucosuria 31,488,637(+) T/C coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A2 Gene

Variant ID Type Subtype PubMed ID
esv3570465 CNV gain 25503493
nsv1060240 CNV gain 25217958
nsv482193 CNV gain 20164927
nsv833194 CNV loss 17160897

Variation tolerance for SLC5A2 Gene

Residual Variation Intolerance Score: 3.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC5A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A2 Gene

Disorders for SLC5A2 Gene

MalaCards: The human disease database

(13) MalaCards diseases for SLC5A2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal glucosuria
  • glys
diabetes mellitus, ketosis-prone
  • kpd
  • intestinal taenia solium infection
- elite association - COSMIC cancer census association via MalaCards


  • Renal glucosuria (GLYS) [MIM:233100]: A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction. {ECO:0000269 PubMed:14614622}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for SLC5A2 Gene


Additional Disease Information for SLC5A2

genes like me logo Genes that share disorders with SLC5A2: view

Publications for SLC5A2 Gene

  1. Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. (PMID: 14614622) Calado J … Rueff J (Human genetics 2004) 3 4 22 58
  2. Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere. (PMID: 8244402) Wells RG … Hediger MA (Genomics 1993) 2 3 22 58
  3. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. (PMID: 1415574) Wells RG … Hediger MA (The American journal of physiology 1992) 3 4 22 58
  4. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. (PMID: 18622023) Calado J … Santer R (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008) 3 22 58
  5. Thioglycosides as inhibitors of hSGLT1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes. (PMID: 17505558) Castaneda F … Kinne RK (International journal of medical sciences 2007) 3 22 58

Products for SLC5A2 Gene

Sources for SLC5A2 Gene

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