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Aliases for MRPL32 Gene

Aliases for MRPL32 Gene

  • Mitochondrial Ribosomal Protein L32 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL32m 3 4
  • MRP-L32 3 4
  • L32mt 3 4
  • 39S Ribosomal Protein L32, Mitochondrial 3
  • BMRP-59b 3
  • HSPC283 3

External Ids for MRPL32 Gene

Previous GeneCards Identifiers for MRPL32 Gene

  • GC07P042618
  • GC07P042712
  • GC07P042745
  • GC07P042938

Summaries for MRPL32 Gene

Entrez Gene Summary for MRPL32 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL32 Gene

MRPL32 (Mitochondrial Ribosomal Protein L32) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL32 Gene

Additional gene information for MRPL32 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL32 Gene

Genomics for MRPL32 Gene

GeneHancer (GH) Regulatory Elements for MRPL32 Gene

Promoters and enhancers for MRPL32 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J042930 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.1 -65 3.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ZNF207 ENSG00000256646 MRPL32 PSMA2 C7orf25 LOC105375252
GH07J042911 Promoter/Enhancer 1.6 Ensembl ENCODE 9.2 -20.0 -20007 2.3 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B C7orf25 MRPL32 ENSG00000261019 ENSG00000256646
GH07J043619 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.3 +691.4 691379 8.7 PKNOX1 BACH1 EBF1 POLR2B ZNF316 POLR2A ATF7 ETV6 IKZF2 RUNX3 PIR42681 STK17A COA1 MRPL32 DDX56 BLVRA POLM DBNL GC07M043624 GC07P043619
GH07J043734 Enhancer 1.2 Ensembl ENCODE 10.4 +803.4 803391 2.4 PKNOX1 ATF1 ARNT IRF4 GTF3C2 TCF12 POLR2B ZNF766 ATF7 RUNX3 PIR57316 BLVRA DDX56 TMED4 COA1 STK17A POLM ENSG00000228434 MRPL32 LINC00957
GH07J042972 Enhancer 0.9 Ensembl ENCODE 10.6 +41.2 41181 1.8 USF1 CHAMP1 ZNF335 ZNF664 NFYB ZNF143 CBFA2T2 FOSL2 PRDM10 THAP11 MRPL32 C7orf25 PSMA2 GC07P043096 LOC105375253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL32 gene promoter:
  • AML1a
  • POU3F2
  • MEF-2A
  • aMEF-2
  • AP-2rep
  • FOXL1
  • AREB6

Genomic Locations for MRPL32 Gene

Genomic Locations for MRPL32 Gene
16,759 bases
Plus strand
16,759 bases
Plus strand

Genomic View for MRPL32 Gene

Genes around MRPL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL32 Gene

Proteins for MRPL32 Gene

  • Protein details for MRPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L32, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q96Q68
    • Q9P098

    Protein attributes for MRPL32 Gene

    188 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bL32m has a zinc binding site.

    Three dimensional structures from OCA and Proteopedia for MRPL32 Gene

neXtProt entry for MRPL32 Gene

Post-translational modifications for MRPL32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL32 Gene

Domains & Families for MRPL32 Gene

Gene Families for MRPL32 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for MRPL32 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bacterial ribosomal protein bL32 family.
  • Belongs to the bacterial ribosomal protein bL32 family.
genes like me logo Genes that share domains with MRPL32: view

Function for MRPL32 Gene

Gene Ontology (GO) - Molecular Function for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,NAS 11543634
genes like me logo Genes that share ontologies with MRPL32: view
genes like me logo Genes that share phenotypes with MRPL32: view

Animal Model Products

miRNA for MRPL32 Gene

miRTarBase miRNAs that target MRPL32

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL32 Gene

Localization for MRPL32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL32 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL32 gene
Compartment Confidence
mitochondrion 5
extracellular 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL32 Gene

Pathways & Interactions for MRPL32 Gene

genes like me logo Genes that share pathways with MRPL32: view

Gene Ontology (GO) - Biological Process for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL32: view

No data available for SIGNOR curated interactions for MRPL32 Gene

Drugs & Compounds for MRPL32 Gene

No Compound Related Data Available

Transcripts for MRPL32 Gene

mRNA/cDNA for MRPL32 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(170) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL32 Gene

Mitochondrial ribosomal protein L32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: - -

Relevant External Links for MRPL32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL32 Gene

Protein differential expression in normal tissues from HIPED for MRPL32 Gene

This gene is overexpressed in Lung (28.4) and Pancreas (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL32 Gene

Protein tissue co-expression partners for MRPL32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL32 Gene:


SOURCE GeneReport for Unigene cluster for MRPL32 Gene:


Evidence on tissue expression from TISSUES for MRPL32 Gene

  • Blood(4.1)
  • Heart(2)
  • Kidney(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with MRPL32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL32 Gene

Orthologs for MRPL32 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL32 34 33
  • 99.11 (n)
(Canis familiaris)
Mammalia MRPL32 34 33
  • 86.52 (n)
(Bos Taurus)
Mammalia MRPL32 34 33
  • 84.93 (n)
(Rattus norvegicus)
Mammalia Mrpl32 33
  • 80.04 (n)
(Mus musculus)
Mammalia Mrpl32 16 34 33
  • 79.32 (n)
Gm6578 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL32 34
  • 63 (a)
(Monodelphis domestica)
Mammalia MRPL32 34
  • 58 (a)
(Gallus gallus)
Aves MRPL32 34 33
  • 62.68 (n)
(Anolis carolinensis)
Reptilia MRPL32 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl32 33
  • 62.76 (n)
Str.6331 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7971 33
(Danio rerio)
Actinopterygii mrpl32 34 33
  • 64.07 (n)
Dr.19923 33
fruit fly
(Drosophila melanogaster)
Insecta mRpL32 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea mrpl-32 34
  • 25 (a)
Species where no ortholog for MRPL32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL32 Gene

Gene Tree for MRPL32 (if available)
Gene Tree for MRPL32 (if available)
Evolutionary constrained regions (ECRs) for MRPL32: view image

Paralogs for MRPL32 Gene Pseudogenes for MRPL32 Gene

genes like me logo Genes that share paralogs with MRPL32: view

No data available for Paralogs for MRPL32 Gene

Variants for MRPL32 Gene

Sequence variations from dbSNP and Humsavar for MRPL32 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000138292 -- 42,932,316(+) C/T genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000299247 -- 42,932,186(+) G/A/T upstream_transcript_variant
rs1000526844 -- 42,937,974(+) A/G downstream_transcript_variant
rs1000596877 -- 42,936,599(+) A/G intron_variant
rs1000629327 -- 42,936,945(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL32 Gene

Variant ID Type Subtype PubMed ID
nsv606715 CNV gain 21841781
nsv830979 CNV gain 17160897

Variation tolerance for MRPL32 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL32 Gene

Disorders for MRPL32 Gene

Additional Disease Information for MRPL32

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL32 Gene

Publications for MRPL32 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 58
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4 58

Products for MRPL32 Gene

Sources for MRPL32 Gene

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