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Aliases for MRPS5 Gene

Aliases for MRPS5 Gene

  • Mitochondrial Ribosomal Protein S5 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US5m 3 4
  • Mitochondrial 28S Ribosomal Protein S5 2 3
  • MRP-S5 3 4
  • S5mt 3 4
  • 28S Ribosomal Protein S5, Mitochondrial 3

External Ids for MRPS5 Gene

Previous GeneCards Identifiers for MRPS5 Gene

  • GC02M093650
  • GC02M094186
  • GC02M095220
  • GC02M095237
  • GC02M095174
  • GC02M095752
  • GC02M089781

Summaries for MRPS5 Gene

Entrez Gene Summary for MRPS5 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS5 Gene

MRPS5 (Mitochondrial Ribosomal Protein S5) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS5 Gene

Additional gene information for MRPS5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS5 Gene

Genomics for MRPS5 Gene

GeneHancer (GH) Regulatory Elements for MRPS5 Gene

Promoters and enhancers for MRPS5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J095120 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.3 +27.8 27828 2 HDGF CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 MRPS5 ZNF514 LOC105373488
GH02J095158 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.4 -10.1 -10120 2.2 HDAC1 RB1 SIN3A DMAP1 ZBTB40 ZNF335 ZNF614 GLIS2 THAP11 SMAD5 ZNF514 LOC101926959 MRPS5
GH02J095073 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.2 +73.8 73842 4.4 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 ZNF143 SP3 REST ZNF592 SSRP1 LOC105373488 KCNIP3 ENSG00000231062 TEKT4 MRPS5
GH02J095115 Enhancer 0.8 ENCODE 0.3 +33.9 33913 0.1 ELF3 FOXA2 ARID4B ZSCAN9 RAD21 SLC30A9 ZNF614 PRPF4 ZNF143 BCLAF1 TEKT4 MRPS5 LOC105373488
GH02J095079 Enhancer 0.6 dbSUPER 0.2 +69.9 69867 1 CTCF SRF ATF1 FOXA2 NANOG RB1 FOXA3 HLF RAD21 ATF2 ZNF514 KCNIP3 LOC105373488 MRPS5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS5 gene promoter:
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • Sp1
  • YY1
  • Arnt
  • ZID

Genomic Locations for MRPS5 Gene

Genomic Locations for MRPS5 Gene
62,228 bases
Minus strand
62,228 bases
Minus strand

Genomic View for MRPS5 Gene

Genes around MRPS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS5 Gene

Proteins for MRPS5 Gene

  • Protein details for MRPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S5, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q4ZFY5
    • Q96LJ6
    • Q9BWI4
    • Q9BYC4

    Protein attributes for MRPS5 Gene

    430 amino acids
    Molecular mass:
    48006 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS5 Gene

    Alternative splice isoforms for MRPS5 Gene


neXtProt entry for MRPS5 Gene

Post-translational modifications for MRPS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS5 Gene

No data available for DME Specific Peptides for MRPS5 Gene

Domains & Families for MRPS5 Gene

Gene Families for MRPS5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for MRPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS5 family.
  • Belongs to the universal ribosomal protein uS5 family.
genes like me logo Genes that share domains with MRPS5: view

Function for MRPS5 Gene

Gene Ontology (GO) - Molecular Function for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPS5: view
genes like me logo Genes that share phenotypes with MRPS5: view

Animal Models for MRPS5 Gene

MGI Knock Outs for MRPS5:
  • Mrps5 Mrps5<tm1b(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS5 Gene

Localization for MRPS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS5 gene
Compartment Confidence
mitochondrion 5
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 25838379
GO:0005840 ribosome IEA --
GO:0022627 NOT cytosolic small ribosomal subunit IBA --
genes like me logo Genes that share ontologies with MRPS5: view

Pathways & Interactions for MRPS5 Gene

genes like me logo Genes that share pathways with MRPS5: view

Gene Ontology (GO) - Biological Process for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS5: view

No data available for SIGNOR curated interactions for MRPS5 Gene

Drugs & Compounds for MRPS5 Gene

No Compound Related Data Available

Transcripts for MRPS5 Gene

mRNA/cDNA for MRPS5 Gene

Unigene Clusters for MRPS5 Gene

Mitochondrial ribosomal protein S5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS5 Gene

No ASD Table

Relevant External Links for MRPS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS5 Gene

Protein differential expression in normal tissues from HIPED for MRPS5 Gene

This gene is overexpressed in Lung (25.7) and Breast (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS5 Gene

Protein tissue co-expression partners for MRPS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS5 Gene:


SOURCE GeneReport for Unigene cluster for MRPS5 Gene:


Evidence on tissue expression from TISSUES for MRPS5 Gene

  • Kidney(4.4)
  • Eye(4.2)
  • Nervous system(3.5)
  • Liver(2)
genes like me logo Genes that share expression patterns with MRPS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS5 Gene

Orthologs for MRPS5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS5 34 33
  • 99.69 (n)
(Canis familiaris)
Mammalia MRPS5 34 33
  • 88.29 (n)
(Bos Taurus)
Mammalia MRPS5 34 33
  • 84.88 (n)
(Rattus norvegicus)
Mammalia Mrps5 33
  • 82.33 (n)
(Mus musculus)
Mammalia Mrps5 16 34 33
  • 80.7 (n)
(Monodelphis domestica)
Mammalia MRPS5 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS5 34
  • 68 (a)
(Gallus gallus)
Aves MRPS5 34 33
  • 67.51 (n)
(Anolis carolinensis)
Reptilia MRPS5 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494239 33
  • 68.62 (n)
Str.7009 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2711 33
(Danio rerio)
Actinopterygii mrps5 34 33
  • 62.64 (n)
wufc73g02 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004091 33
  • 51.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS5 34 33
  • 50.7 (n)
(Caenorhabditis elegans)
Secernentea mrps-5 34 33
  • 45.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS5 36 34
  • 23 (a)
Species where no ortholog for MRPS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS5 Gene

Gene Tree for MRPS5 (if available)
Gene Tree for MRPS5 (if available)
Evolutionary constrained regions (ECRs) for MRPS5: view image

Paralogs for MRPS5 Gene Pseudogenes for MRPS5 Gene

genes like me logo Genes that share paralogs with MRPS5: view

No data available for Paralogs for MRPS5 Gene

Variants for MRPS5 Gene

Sequence variations from dbSNP and Humsavar for MRPS5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000079492 -- 95,115,625(-) T/G intron_variant
rs1000146057 -- 95,122,835(-) C/T upstream_transcript_variant
rs1000229494 -- 95,109,502(-) T/A intron_variant
rs1000307074 -- 95,116,228(-) T/A intron_variant
rs1000566149 -- 95,103,569(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS5 Gene

Variant ID Type Subtype PubMed ID
dgv4007n100 CNV gain 25217958
esv3591652 OTHER inversion 21293372
esv3591662 CNV gain 21293372
nsv1160825 CNV duplication 26073780

Variation tolerance for MRPS5 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS5 Gene

Disorders for MRPS5 Gene

Additional Disease Information for MRPS5

No disorders were found for MRPS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS5 Gene

Publications for MRPS5 Gene

  1. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 3 4 58
  5. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. (PMID: 11402041) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4 58

Products for MRPS5 Gene

Sources for MRPS5 Gene

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