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Aliases for RASAL3 Gene

Aliases for RASAL3 Gene

  • RAS Protein Activator Like 3 2 3 5
  • RAS Protein Activator Like-3 3

External Ids for RASAL3 Gene

Previous GeneCards Identifiers for RASAL3 Gene

  • GC19M015426
  • GC19M015562
  • GC19M015132

Summaries for RASAL3 Gene

Entrez Gene Summary for RASAL3 Gene

  • This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

GeneCards Summary for RASAL3 Gene

RASAL3 (RAS Protein Activator Like 3) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASAL2.

UniProtKB/Swiss-Prot for RASAL3 Gene

  • Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.

Additional gene information for RASAL3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL3 Gene

Genomics for RASAL3 Gene

GeneHancer (GH) Regulatory Elements for RASAL3 Gene

Promoters and enhancers for RASAL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015463 Promoter/Enhancer 1.3 Ensembl ENCODE 663.9 +0.3 315 2.1 HDGF RAD21 ZNF207 ZNF143 ETV6 BCLAF1 IKZF2 RUNX3 CREM SMARCA5 RASAL3 WIZ GC19M015202
GH19J015466 Enhancer 1.2 FANTOM5 Ensembl ENCODE 14.7 -2.4 -2362 1.9 PTBP1 BATF ZNF366 ZNF143 FOS ETV6 RCOR1 IKZF2 RUNX3 CREM RASAL3 GC19M015481 GC19M015202
GH19J015295 Enhancer 1.4 Ensembl ENCODE dbSUPER 11 +165.9 165852 5.8 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZNF766 SP5 AKAP8 ZNF333 BRD4 EPHX3 NOTCH3 RASAL3 ENSG00000268189 SNRPGP15 RNU6-782P CYP4F24P
GH19J015550 Enhancer 1 Ensembl ENCODE 12.2 -86.8 -86837 1.2 KLF14 ZNF335 GLIS2 EGR1 KLF13 EGR2 SP3 USF2 SP1 NFIC CYP4F22 PGLYRP2 RASAL3 AKAP8L CYP4F11 GC19P015545 CYP4F23P
GH19J015291 Enhancer 1 Ensembl ENCODE dbSUPER 11 +171.3 171285 4.6 HLF CEBPB EBF1 REST ZEB2 ZIC2 SCRT2 ZNF629 PRDM10 ZNF600 GC19P015294 BRD4 AKAP8 AKAP8L EPHX3 RASAL3 RNU6-782P SYDE1 GC19P015309 GC19M015202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASAL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASAL3 gene promoter:
  • AP-1
  • Sp1
  • GR-beta
  • GR
  • GR-alpha
  • CP2

Genomic Locations for RASAL3 Gene

Genomic Locations for RASAL3 Gene
12,948 bases
Minus strand
12,948 bases
Minus strand

Genomic View for RASAL3 Gene

Genes around RASAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL3 Gene

Proteins for RASAL3 Gene

  • Protein details for RASAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RAS protein activator like-3
    Protein Accession:
    Secondary Accessions:
    • Q8N2T9
    • Q9H735

    Protein attributes for RASAL3 Gene

    1011 amino acids
    Molecular mass:
    111898 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30281.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15064.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC56928.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC56928.1; Type=Erroneous termination; Positions=723; Note=Translated as Arg.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL3 Gene


neXtProt entry for RASAL3 Gene

Post-translational modifications for RASAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASAL3 Gene

Domains & Families for RASAL3 Gene

Gene Families for RASAL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RASAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RASAL3: view

No data available for UniProtKB/Swiss-Prot for RASAL3 Gene

Function for RASAL3 Gene

Molecular function for RASAL3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.

Phenotypes From GWAS Catalog for RASAL3 Gene

Gene Ontology (GO) - Molecular Function for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RASAL3: view
genes like me logo Genes that share phenotypes with RASAL3: view

Animal Models for RASAL3 Gene

MGI Knock Outs for RASAL3:

Animal Model Products

miRNA for RASAL3 Gene

miRTarBase miRNAs that target RASAL3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASAL3 Gene

Localization for RASAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASAL3 Gene

Cytoplasm. Cytoplasm, cell cortex.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASAL3 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25652366
GO:0005829 cytosol TAS --
GO:0005938 cell cortex IEA --
GO:0016020 membrane HDA 19946888
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASAL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASAL3 Gene

Pathways & Interactions for RASAL3 Gene

SuperPathways for RASAL3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
5 Innate Immune System
genes like me logo Genes that share pathways with RASAL3: view

Pathways by source for RASAL3 Gene

Gene Ontology (GO) - Biological Process for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA --
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046580 negative regulation of Ras protein signal transduction IMP 25652366
genes like me logo Genes that share ontologies with RASAL3: view

No data available for SIGNOR curated interactions for RASAL3 Gene

Drugs & Compounds for RASAL3 Gene

No Compound Related Data Available

Transcripts for RASAL3 Gene

Unigene Clusters for RASAL3 Gene

RAS protein activator like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP3: - -
SP5: - - -
SP9: -

Relevant External Links for RASAL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASAL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASAL3 Gene

mRNA differential expression in normal tissues according to GTEx for RASAL3 Gene

This gene is overexpressed in Whole Blood (x17.0), Spleen (x7.6), and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for RASAL3 Gene

This gene is overexpressed in Tlymphocyte (26.0), Peripheral blood mononuclear cells (19.3), NK cells (8.6), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RASAL3 Gene

Protein tissue co-expression partners for RASAL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RASAL3 Gene:


SOURCE GeneReport for Unigene cluster for RASAL3 Gene:


mRNA Expression by UniProt/SwissProt for RASAL3 Gene:

Tissue specificity: Predominantly expressed in cells of hematopoietic lineages.

Evidence on tissue expression from TISSUES for RASAL3 Gene

  • Intestine(4.3)
  • Spleen(4.3)
  • Blood(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RASAL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASAL3 Gene

Orthologs for RASAL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASAL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RASAL3 34 33
  • 85.87 (n)
(Bos Taurus)
Mammalia RASAL3 34 33
  • 83.75 (n)
(Mus musculus)
Mammalia Rasal3 16 34 33
  • 80.17 (n)
(Rattus norvegicus)
Mammalia Rasal3 33
  • 79.74 (n)
(Monodelphis domestica)
Mammalia RASAL3 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia RASAL3 34
  • 59 (a)
(Gallus gallus)
Aves RASAL3 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal3 33
  • 50.33 (n)
(Danio rerio)
Actinopterygii rasal3 34
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42684 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea gap-2 34
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD2 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6146 34
  • 23 (a)
Species where no ortholog for RASAL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL3 Gene

Gene Tree for RASAL3 (if available)
Gene Tree for RASAL3 (if available)
Evolutionary constrained regions (ECRs) for RASAL3: view image

Paralogs for RASAL3 Gene

Paralogs for RASAL3 Gene

(4) SIMAP similar genes for RASAL3 Gene using alignment to 3 proteins:

  • M0QX12_HUMAN
genes like me logo Genes that share paralogs with RASAL3: view

Variants for RASAL3 Gene

Sequence variations from dbSNP and Humsavar for RASAL3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs76267899 uncertain-significance, Acute megakaryoblastic leukemia, Mediastinal germ cell tumor 15,464,363(-) G/A/C/T 5_prime_UTR_variant, non_coding_transcript_variant
rs1000266910 -- 15,461,365(-) G/C intron_variant
rs1000599366 -- 15,463,033(-) T/C intron_variant
rs1000651772 -- 15,462,716(-) G/C intron_variant
rs1000833888 -- 15,459,107(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RASAL3 Gene

Variant ID Type Subtype PubMed ID
esv2551856 CNV deletion 19546169
nsv1064684 CNV gain 25217958
nsv1118816 CNV deletion 24896259
nsv1131404 CNV deletion 24896259
nsv482216 CNV loss 20164927
nsv833765 CNV loss 17160897

Variation tolerance for RASAL3 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASAL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASAL3 Gene

Disorders for RASAL3 Gene

Additional Disease Information for RASAL3

No disorders were found for RASAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASAL3 Gene

Publications for RASAL3 Gene

  1. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. (PMID: 25652366) Saito S … Fujii M (European journal of immunology 2015) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for RASAL3 Gene

Sources for RASAL3 Gene

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