Aliases for NABP1 Gene
- Nucleic Acid Binding Protein 1 2 3 5
- Sensor Of Single-Strand DNA Complex Subunit B2 2 3 4
- Single-Stranded DNA-Binding Protein 2 2 3 4
- Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2A 3 4
- Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A 2 3
- Sensor Of SsDNA Subunit B2 3 4
- SOSS-B2 3 4
External Ids for NABP1 Gene
Previous HGNC Symbols for NABP1 Gene
Previous GeneCards Identifiers for NABP1 Gene
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
GeneCards Summary for NABP1 Gene
NABP1 (Nucleic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with NABP1 include Acute Promyelocytic Leukemia. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NABP2.
UniProtKB/Swiss-Prot for NABP1 Gene
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.