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Aliases for ST6GAL1 Gene

Aliases for ST6GAL1 Gene

  • ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1 2 3 5
  • ST6Gal I 2 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 1 3 4
  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 2 3
  • ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 1 2 3
  • B-Cell Antigen CD75 3 4
  • Alpha 2,6-ST 1 3 4
  • EC 4 56
  • ST6GalI 3 4
  • SIAT1 3 4
  • CMP-N-Acetylneuraminate Beta-Galactosamide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialyltransferase) 3
  • Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialytransferase) 2
  • Beta-Galactoside Alpha-2,6-Sialyltransferase 1 3
  • Sialyltransferase 1 4
  • ST6N 3

External Ids for ST6GAL1 Gene

Previous HGNC Symbols for ST6GAL1 Gene

  • SIAT1

Previous GeneCards Identifiers for ST6GAL1 Gene

  • GC03P188132
  • GC03P186648
  • GC03P184054

Summaries for ST6GAL1 Gene

Entrez Gene Summary for ST6GAL1 Gene

  • This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

GeneCards Summary for ST6GAL1 Gene

ST6GAL1 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1) is a Protein Coding gene. Diseases associated with ST6GAL1 include Colon Adenocarcinoma and Colorectal Cancer. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GAL2.

UniProtKB/Swiss-Prot for ST6GAL1 Gene

  • Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Gene Wiki entry for ST6GAL1 Gene

Additional gene information for ST6GAL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GAL1 Gene

Genomics for ST6GAL1 Gene

GeneHancer (GH) Regulatory Elements for ST6GAL1 Gene

Promoters and enhancers for ST6GAL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I186930 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 562 +1.7 1655 4.6 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ST6GAL1 GC03P186932 SNORA4 RFC4 TRA2B TBCCD1 SNORA81 ADIPOQ ENSG00000200418 SNORA63
GH03I187019 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 572.7 +94.4 94365 11 HDGF PKNOX1 FOXA2 SMAD1 ARNT YBX1 ZNF766 CBX5 E2F8 ZNF143 ST6GAL1 ADIPOQ ADIPOQ-AS1 RTP4 EIF4A2 TBCCD1 RTP1 GC03P186996 GC03P186997 PIR46786
GH03I186929 Enhancer 0.4 ENCODE dbSUPER 550.8 -0.9 -894 0 ST6GAL1 RPL29P9
GH03I186985 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.5 +55.9 55936 1.8 HDAC1 TCF12 ETV6 ATF7 IKZF2 RUNX3 CEBPB NCOA1 ELF1 SMARCA4 ST6GAL1 LOC101929079 GC03P186932
GH03I186908 Enhancer 1.1 Ensembl ENCODE 21.2 -21.0 -21023 1.5 HDGF ATF1 TAF9B NFRKB ZNF48 ZBTB40 TCF12 POLR2B ZNF766 CBX5 ST6GAL1 ADIPOQ-AS1 ADIPOQ RPS20P14 GC03M186923
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST6GAL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST6GAL1 gene promoter:

Genomic Locations for ST6GAL1 Gene

Genomic Locations for ST6GAL1 Gene
148,211 bases
Plus strand

Genomic View for ST6GAL1 Gene

Genes around ST6GAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GAL1 Gene

Proteins for ST6GAL1 Gene

  • Protein details for ST6GAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • A8KA14
    • B2R513
    • D3DNV3

    Protein attributes for ST6GAL1 Gene

    406 amino acids
    Molecular mass:
    46605 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ST6GAL1 Gene

    Alternative splice isoforms for ST6GAL1 Gene


neXtProt entry for ST6GAL1 Gene

Selected DME Specific Peptides for ST6GAL1 Gene


Post-translational modifications for ST6GAL1 Gene

  • The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at posLast=6868, isoforms=149, and posLast=161161
  • Modification sites at PhosphoSitePlus

Domains & Families for ST6GAL1 Gene

Gene Families for ST6GAL1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ST6GAL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GAL1: view

Function for ST6GAL1 Gene

Molecular function for ST6GAL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=530 uM for CMP-NeuAc {ECO:0000269 PubMed:21081508}; Vmax=1.074 pmol/min/ug enzyme {ECO:0000269 PubMed:21081508};
UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by CTP.
UniProtKB/Swiss-Prot Function:
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Enzyme Numbers (IUBMB) for ST6GAL1 Gene

Phenotypes From GWAS Catalog for ST6GAL1 Gene

Gene Ontology (GO) - Molecular Function for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity TAS --
GO:0005515 protein binding IPI 16237761
GO:0008373 sialyltransferase activity IDA 21081508
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GAL1: view
genes like me logo Genes that share phenotypes with ST6GAL1: view

Animal Models for ST6GAL1 Gene

MGI Knock Outs for ST6GAL1:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST6GAL1 Gene

Localization for ST6GAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GAL1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GAL1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
endoplasmic reticulum 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GAL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GAL1 Gene

Pathways & Interactions for ST6GAL1 Gene

genes like me logo Genes that share pathways with ST6GAL1: view

UniProtKB/Swiss-Prot P15907-SIAT1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006054 N-acetylneuraminate metabolic process IDA 23999306
GO:0006486 protein glycosylation IEA --
GO:0006959 humoral immune response TAS 7786324
GO:0009311 oligosaccharide metabolic process IBA --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with ST6GAL1: view

No data available for SIGNOR curated interactions for ST6GAL1 Gene

Drugs & Compounds for ST6GAL1 Gene

(3) Drugs for ST6GAL1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(10) Additional Compounds for ST6GAL1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (N-acetylneuraminosyl(alpha2-6)lactosamine)
  • 6'-Sialyllactosamine
  • a-N-Acetylneuraminyl-2,6-b-D-galactosyl-1,4-N-acetyl-b-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-delta-galactosyl-1,4-N-acetyl-beta-delta-glucosamine
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
genes like me logo Genes that share compounds with ST6GAL1: view

Transcripts for ST6GAL1 Gene

Unigene Clusters for ST6GAL1 Gene

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GAL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - -
SP2: - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP8: - - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - - -
SP13: -
SP14: - -
SP15: - - -

ExUns: 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c ^ 19a · 19b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - -

Relevant External Links for ST6GAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GAL1 Gene

This gene is overexpressed in Liver (x15.8).

Protein differential expression in normal tissues from HIPED for ST6GAL1 Gene

This gene is overexpressed in Liver (20.9), Serum (20.8), Plasma (9.2), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST6GAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST6GAL1 Gene:


SOURCE GeneReport for Unigene cluster for ST6GAL1 Gene:


Evidence on tissue expression from TISSUES for ST6GAL1 Gene

  • Liver(4.7)
  • Skin(4.3)
  • Spleen(4.3)
  • Nervous system(4.1)
  • Kidney(2.7)
  • Intestine(2.5)
  • Lymph node(2.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ST6GAL1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GAL1 Gene

Orthologs for ST6GAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIAT1 34
  • 100 (a)
ST6GAL1 33
  • 99.51 (n)
(Canis familiaris)
Mammalia ST6GAL1 33 34
  • 88.64 (n)
(Bos Taurus)
Mammalia ST6GAL1 33 34
  • 85.49 (n)
(Mus musculus)
Mammalia St6gal1 33 16 34
  • 82.46 (n)
(Rattus norvegicus)
Mammalia St6gal1 33
  • 82.46 (n)
(Monodelphis domestica)
Mammalia ST6GAL1 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
(Gallus gallus)
Aves ST6GAL1 33 34
  • 65.01 (n)
(Anolis carolinensis)
Reptilia ST6GAL1 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st6gal1 33
  • 58.89 (n)
(Danio rerio)
Actinopterygii st6gal1 33 34
  • 56.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 34
  • 25 (a)
Species where no ortholog for ST6GAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GAL1 Gene

Gene Tree for ST6GAL1 (if available)
Gene Tree for ST6GAL1 (if available)

Paralogs for ST6GAL1 Gene

Variants for ST6GAL1 Gene

Sequence variations from dbSNP and Humsavar for ST6GAL1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000008282 -- 187,003,743(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000015928 -- 187,000,174(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000018891 -- 187,013,564(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000031685 -- 187,045,928(+) G/A intron_variant
rs1000065591 -- 187,052,066(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GAL1 Gene

Variant ID Type Subtype PubMed ID
esv1371504 CNV deletion 17803354
esv1985985 CNV deletion 18987734
esv2726343 CNV deletion 23290073
esv2726344 CNV deletion 23290073
esv2726345 CNV deletion 23290073
esv2759207 CNV loss 17122850
esv34136 CNV loss 18971310
esv3569168 CNV loss 25503493
esv3599004 CNV loss 21293372
esv3893839 CNV gain 25118596
nsv1001111 CNV gain 25217958
nsv1003732 CNV gain 25217958
nsv1004008 CNV gain 25217958
nsv1012615 CNV gain 25217958
nsv1114461 CNV deletion 24896259
nsv4156 CNV deletion 18451855
nsv477787 CNV novel sequence insertion 20440878
nsv478351 CNV novel sequence insertion 20440878
nsv508975 CNV insertion 20534489
nsv519618 CNV loss 19592680

Variation tolerance for ST6GAL1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST6GAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GAL1 Gene

Disorders for ST6GAL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ST6GAL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colon adenocarcinoma
  • adenocarcinoma of colon
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST6GAL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST6GAL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST6GAL1 Gene

Publications for ST6GAL1 Gene

  1. Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase. (PMID: 2408023) Grundmann U … Zettlmeissl G (Nucleic acids research 1990) 2 3 4 58
  2. The B cell antigen CD75 is a cell surface sialytransferase. (PMID: 2373995) Stamenkovic I … Funderud S (The Journal of experimental medicine 1990) 3 4 22 58
  3. The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans. (PMID: 23999306) Kuhn B … Rudolph MG (Acta crystallographica. Section D, Biological crystallography 2013) 3 4 58
  4. Universal phosphatase-coupled glycosyltransferase assay. (PMID: 21081508) Wu ZL … Jiang W (Glycobiology 2011) 3 4 58
  5. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner JS … Chambers JC (Nature genetics 2011) 3 44 58

Products for ST6GAL1 Gene

Sources for ST6GAL1 Gene

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