Aliases for GORASP1 Gene
External Ids for GORASP1 Gene
Previous HGNC Symbols for GORASP1 Gene
Previous GeneCards Identifiers for GORASP1 Gene
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for GORASP1 Gene
GORASP1 (Golgi Reassembly Stacking Protein 1) is a Protein Coding gene. Diseases associated with GORASP1 include Long Qt Syndrome. Among its related pathways are Cell Cycle, Mitotic and Transport to the Golgi and subsequent modification. An important paralog of this gene is GORASP2.
UniProtKB/Swiss-Prot for GORASP1 Gene
Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).