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Aliases for GORASP1 Gene

Aliases for GORASP1 Gene

  • Golgi Reassembly Stacking Protein 1 2 3 5
  • Golgi Phosphoprotein 5 2 3 4
  • Golgi Reassembly-Stacking Protein Of 65 KDa 3 4
  • Golgi Reassembly Stacking Protein 1, 65kDa 2 3
  • Golgi Peripheral Membrane Protein P65 3 4
  • GRASP65 3 4
  • GOLPH5 3 4
  • Golgi Reassembly And Stacking Protein 1 3
  • Golgi Reassembly-Stacking Protein 1 3
  • P65 3

External Ids for GORASP1 Gene

Previous HGNC Symbols for GORASP1 Gene

  • GOLPH5

Previous GeneCards Identifiers for GORASP1 Gene

  • GC03M038478
  • GC03P038045
  • GC03M038951
  • GC03M039098

Summaries for GORASP1 Gene

Entrez Gene Summary for GORASP1 Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for GORASP1 Gene

GORASP1 (Golgi Reassembly Stacking Protein 1) is a Protein Coding gene. Diseases associated with GORASP1 include Long Qt Syndrome. Among its related pathways are Cell Cycle, Mitotic and Transport to the Golgi and subsequent modification. An important paralog of this gene is GORASP2.

UniProtKB/Swiss-Prot for GORASP1 Gene

  • Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).

Gene Wiki entry for GORASP1 Gene

Additional gene information for GORASP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GORASP1 Gene

Genomics for GORASP1 Gene

GeneHancer (GH) Regulatory Elements for GORASP1 Gene

Promoters and enhancers for GORASP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J039106 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663.6 +0.8 768 2.7 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 SP3 SP5 TTC21A GORASP1 CX3CR1 CSRNP1 MOBP SCN11A GC03M039097 PIR55888
GH03J039145 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 81.9 -42.7 -42734 10.7 CLOCK FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 MEF2D CSRNP1 ENSG00000283849 LOC101928263 GORASP1 SNORA62 TTC21A CX3CR1 OXSR1 WDR48 XIRP1
GH03J039382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 49.6 -275.4 -275419 2.7 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 SLC25A38 LOC105377644 GORASP1 RPSA SNORA62 WDR48 XIRP1 GC03M039393
GH03J038346 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.8 +761.2 761221 2 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 XYLB GORASP1 WDR48 OXSR1 C3orf35 SCN11A PIR42930
GH03J038163 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.8 +941.2 941165 8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 OXSR1 LOC101928234 GORASP1 C3orf35 ACAA1 MYD88 SLC22A13 ACVR2B-AS1 VILL PLCD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GORASP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GORASP1 gene promoter:
  • Max1
  • Tal-1
  • E47
  • HNF-4alpha1
  • LCR-F1
  • Pax-5
  • COMP1
  • AML1a
  • NF-AT4

Genomic Locations for GORASP1 Gene

Genomic Locations for GORASP1 Gene
chr3:39,096,599-39,108,363
(GRCh38/hg38)
Size:
11,765 bases
Orientation:
Minus strand
chr3:39,138,091-39,149,854
(GRCh37/hg19)
Size:
11,764 bases
Orientation:
Minus strand

Genomic View for GORASP1 Gene

Genes around GORASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GORASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GORASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GORASP1 Gene

Proteins for GORASP1 Gene

  • Protein details for GORASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQQ3-GORS1_HUMAN
    Recommended name:
    Golgi reassembly-stacking protein 1
    Protein Accession:
    Q9BQQ3
    Secondary Accessions:
    • B3KWC8
    • Q3SYG7
    • Q8N272
    • Q96H42

    Protein attributes for GORASP1 Gene

    Size:
    440 amino acids
    Molecular mass:
    46482 Da
    Quaternary structure:
    • Homodimer. Forms higher-order oligomers under interphase but not mitotic conditions. Dimers of the protein on one membrane might be able to interact with dimers on another and so stack cisternae (By similarity). Interacts with the C-terminus of GOLGA2/GM130 under both mitotic and non-mitotic conditions (PubMed:16489344). The interaction is critical for the correct targeting of both proteins to the cis-Golgi (By similarity). The complex binds to the vesicle docking protein p115/USO1. Interacts with TMED2 and TMED3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GORASP1 Gene

    Alternative splice isoforms for GORASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GORASP1 Gene

Post-translational modifications for GORASP1 Gene

  • Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking.
  • Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GORASP1 Gene

Domains & Families for GORASP1 Gene

Gene Families for GORASP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GORASP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BQQ3

UniProtKB/Swiss-Prot:

GORS1_HUMAN :
  • Belongs to the GORASP family.
Family:
  • Belongs to the GORASP family.
genes like me logo Genes that share domains with GORASP1: view

Function for GORASP1 Gene

Molecular function for GORASP1 Gene

UniProtKB/Swiss-Prot Function:
Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).

Phenotypes From GWAS Catalog for GORASP1 Gene

Gene Ontology (GO) - Molecular Function for GORASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16489344
genes like me logo Genes that share ontologies with GORASP1: view
genes like me logo Genes that share phenotypes with GORASP1: view

Animal Models for GORASP1 Gene

MGI Knock Outs for GORASP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GORASP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GORASP1 Gene

Localization for GORASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GORASP1 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Undergoes rapid exchange with the cytosol. {ECO:0000269 PubMed:11706049}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GORASP1 gene
Compartment Confidence
golgi apparatus 5
nucleus 2
cytosol 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GORASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 18045989
GO:0016020 membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS --
genes like me logo Genes that share ontologies with GORASP1: view

Pathways & Interactions for GORASP1 Gene

genes like me logo Genes that share pathways with GORASP1: view

Pathways by source for GORASP1 Gene

Gene Ontology (GO) - Biological Process for GORASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007030 Golgi organization ISS --
GO:0015031 protein transport IEA --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with GORASP1: view

No data available for SIGNOR curated interactions for GORASP1 Gene

Drugs & Compounds for GORASP1 Gene

(3) Drugs for GORASP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GORASP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GORASP1: view

Transcripts for GORASP1 Gene

Unigene Clusters for GORASP1 Gene

Golgi reassembly stacking protein 1, 65kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GORASP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GORASP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h · 4i · 4j ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: -
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - -
SP20: - - - - - - - - - - - - - - - - - - -
SP21: - - - - -
SP22: - - - - - -
SP23: - - - - - - -
SP24: - - - - - - - - - - - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - - - -
SP26: - - - - - -
SP27:
SP28: - - - -
SP29: - - - - - - - - - - - - - - - - - - -
SP30: - -
SP31:

ExUns: 8c · 8d · 8e · 8f · 8g · 8h ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11: - -
SP12: - - - - - - - - -
SP13: - -
SP14: - - - - - - -
SP15:
SP16:
SP17: - - - - - -
SP18:
SP19:
SP20: - - - -
SP21:
SP22:
SP23:
SP24: - -
SP25: - - - - - - - - - - -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:

Relevant External Links for GORASP1 Gene

GeneLoc Exon Structure for
GORASP1
ECgene alternative splicing isoforms for
GORASP1

Expression for GORASP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GORASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GORASP1 Gene

This gene is overexpressed in Liver (13.3), Pancreas (9.4), Retina (8.9), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GORASP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GORASP1 Gene:

GORASP1

SOURCE GeneReport for Unigene cluster for GORASP1 Gene:

Hs.721946

Evidence on tissue expression from TISSUES for GORASP1 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Eye(4.2)
  • Liver(4.2)
  • Kidney(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GORASP1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • lymphatic
Regions:
Head and neck:
  • head
  • mouth
Abdomen:
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
Pelvis:
  • anus
  • rectum
General:
  • blood
  • lymph node
  • red blood cell
genes like me logo Genes that share expression patterns with GORASP1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GORASP1 Gene

Orthologs for GORASP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GORASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GORASP1 34 33
  • 99.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GORASP1 34 33
  • 88.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GORASP1 34 33
  • 85.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gorasp1 33
  • 82.63 (n)
mouse
(Mus musculus)
Mammalia Gorasp1 16 34 33
  • 82.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GORASP1 34
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GORASP1 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves GORASP1 34 33
  • 63.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GORASP1 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gorasp1 33
  • 67.25 (n)
zebrafish
(Danio rerio)
Actinopterygii GORASP1 (2 of 3) 34
  • 73 (a)
OneToMany
CU633479.5 34
  • 69 (a)
OneToMany
gorasp1 34
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7809 35
  • 61 (a)
Grasp65 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y42H9AR.1 34 35
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRH1 36 34
  • 19 (a)
Species where no ortholog for GORASP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GORASP1 Gene

ENSEMBL:
Gene Tree for GORASP1 (if available)
TreeFam:
Gene Tree for GORASP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GORASP1: view image

Paralogs for GORASP1 Gene

Paralogs for GORASP1 Gene

(1) SIMAP similar genes for GORASP1 Gene using alignment to 11 proteins:

  • GORS1_HUMAN
  • B3KPY8_HUMAN
  • B4E1H8_HUMAN
  • C9J0V5_HUMAN
  • C9J5S6_HUMAN
  • C9J9V9_HUMAN
  • C9JBH8_HUMAN
  • C9JI27_HUMAN
  • F8WD30_HUMAN
  • G3V0G1_HUMAN
  • H7C0J2_HUMAN
genes like me logo Genes that share paralogs with GORASP1: view

Variants for GORASP1 Gene

Sequence variations from dbSNP and Humsavar for GORASP1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000172032 -- 39,110,173(-) A/G upstream_transcript_variant
rs1000439869 -- 39,102,503(-) G/A intron_variant
rs1000691482 -- 39,105,655(-) A/G intron_variant
rs1001036851 -- 39,103,993(-) C/T intron_variant
rs1001148205 -- 39,096,525(-) C/T downstream_transcript_variant

Variation tolerance for GORASP1 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GORASP1 Gene

Human Gene Mutation Database (HGMD)
GORASP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GORASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GORASP1 Gene

Disorders for GORASP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GORASP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
long qt syndrome
  • romano-ward syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GORASP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GORASP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GORASP1 Gene

Publications for GORASP1 Gene

  1. GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution. (PMID: 16489344) Puthenveedu MA … Linstedt AD (Nature cell biology 2006) 3 4 22 58
  2. The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment. (PMID: 11781572) Marra P … De Matteis MA (Nature cell biology 2001) 3 4 22 58
  3. The role of GRASP65 in Golgi cisternal stacking and cell cycle progression. (PMID: 20214750) Tang D … Wang Y (Traffic (Copenhagen, Denmark) 2010) 3 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking. (PMID: 20083603) Xiang Y … Wang Y (The Journal of cell biology 2010) 3 22 58

Products for GORASP1 Gene

Sources for GORASP1 Gene

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