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Aliases for RNF25 Gene

Aliases for RNF25 Gene

  • Ring Finger Protein 25 2 3
  • RING-Type E3 Ubiquitin Transferase RNF25 3 4
  • RING Finger Protein 25 4 5
  • E3 Ubiquitin-Protein Ligase RNF25 3
  • Ring Finger Protein AO7 3
  • EC 4
  • AO7 3

External Ids for RNF25 Gene

Previous GeneCards Identifiers for RNF25 Gene

  • GC02M217544
  • GC02M218249
  • GC02M219492
  • GC02M219731
  • GC02M219354
  • GC02M219236
  • GC02M211382
  • GC02M219528

Summaries for RNF25 Gene

Entrez Gene Summary for RNF25 Gene

  • The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF25 Gene

RNF25 (Ring Finger Protein 25) is a Protein Coding gene. Diseases associated with RNF25 include Congenital Epulis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and NF-kappaB binding.

UniProtKB/Swiss-Prot for RNF25 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Gene Wiki entry for RNF25 Gene

Additional gene information for RNF25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF25 Gene

Genomics for RNF25 Gene

GeneHancer (GH) Regulatory Elements for RNF25 Gene

Promoters and enhancers for RNF25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I218670 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 492 2.1 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 MXD4 RNF25 STK36 CNOT9 ZNF142 PLCD4
GH02I219569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.9 -899.1 -899120 4 PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 INHA OBSL1 ZNF142 RNF25 NHEJ1 SLC23A3 STK36 STK11IP GLB1L DNPEP
GH02I219495 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20 -825.6 -825615 5 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000268603 GC02M219493 GMPPA ZNF142 STK36 RNF25 CNOT9 USP37 NHEJ1 STK11IP
GH02I219368 Enhancer 1.1 Ensembl ENCODE 29.9 -696.9 -696895 2.4 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 RXRA YY2 REST TSHZ1 LOC105373883 ZNF142 STK36 CNOT9 RNF25 ENSG00000269068 STK11IP ENSG00000268896 ANKZF1 OBSL1
GH02I218393 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +271.4 271404 14.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 GC02P218403 ENSG00000273361 MIR26B CTDSP1 CNOT9 AAMP USP37 STK36 ANKZF1 BCS1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF25 gene promoter:

Genomic Locations for RNF25 Gene

Genomic Locations for RNF25 Gene
8,548 bases
Minus strand

Genomic View for RNF25 Gene

Genes around RNF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF25 Gene

Proteins for RNF25 Gene

  • Protein details for RNF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF25
    Protein Accession:
    Secondary Accessions:
    • A8K0D6
    • Q53HQ5
    • Q9H874

    Protein attributes for RNF25 Gene

    459 amino acids
    Molecular mass:
    51219 Da
    Quaternary structure:
    • Interacts with UBE2D2, and may also interact with UBE2E1 and UBE2E3. Interacts with NKD2 (By similarity). Interacts with RELA.

    Three dimensional structures from OCA and Proteopedia for RNF25 Gene

neXtProt entry for RNF25 Gene

Post-translational modifications for RNF25 Gene

Other Protein References for RNF25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF25 Gene

Domains & Families for RNF25 Gene

Gene Families for RNF25 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RNF25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
genes like me logo Genes that share domains with RNF25: view

Function for RNF25 Gene

Molecular function for RNF25 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Enzyme Numbers (IUBMB) for RNF25 Gene

Phenotypes From GWAS Catalog for RNF25 Gene

Gene Ontology (GO) - Molecular Function for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 18757723
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051059 NF-kappaB binding IPI 12748188
genes like me logo Genes that share ontologies with RNF25: view
genes like me logo Genes that share phenotypes with RNF25: view

Animal Models for RNF25 Gene

MGI Knock Outs for RNF25:

miRNA for RNF25 Gene

miRTarBase miRNAs that target RNF25

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF25 Gene

Localization for RNF25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF25 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12748188
GO:0005829 cytosol IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF25 Gene

Pathways & Interactions for RNF25 Gene

genes like me logo Genes that share pathways with RNF25: view

UniProtKB/Swiss-Prot Q96BH1-RNF25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination ISS --
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

No data available for SIGNOR curated interactions for RNF25 Gene

Drugs & Compounds for RNF25 Gene

No Compound Related Data Available

Transcripts for RNF25 Gene

Unigene Clusters for RNF25 Gene

Ring finger protein 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10

Relevant External Links for RNF25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF25 Gene

This gene is overexpressed in Rectum (25.5) and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF25 Gene

Protein tissue co-expression partners for RNF25 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF25 Gene:


SOURCE GeneReport for Unigene cluster for RNF25 Gene:


Evidence on tissue expression from TISSUES for RNF25 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RNF25: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF25 Gene

Orthologs for RNF25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF25 33 34
  • 98.91 (n)
(Canis familiaris)
Mammalia RNF25 33 34
  • 90.05 (n)
(Bos Taurus)
Mammalia RNF25 33 34
  • 86.46 (n)
(Rattus norvegicus)
Mammalia Rnf25 33
  • 84.88 (n)
(Mus musculus)
Mammalia Rnf25 33 16 34
  • 84.58 (n)
(Monodelphis domestica)
Mammalia RNF25 34
  • 74 (a)
(Gallus gallus)
Aves RNF25 33 34
  • 57.96 (n)
(Anolis carolinensis)
Reptilia RNF25 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf25 33
  • 56.6 (n)
Str.14059 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25335 33
(Danio rerio)
Actinopterygii rnf25 34
  • 31 (a)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9261 33
fruit fly
(Drosophila melanogaster)
Insecta CG13344 35 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y53G8AR.5 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8459 34
  • 29 (a)
Species where no ortholog for RNF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF25 Gene

Gene Tree for RNF25 (if available)
Gene Tree for RNF25 (if available)

Paralogs for RNF25 Gene

No data available for Paralogs for RNF25 Gene

Variants for RNF25 Gene

Sequence variations from dbSNP and Humsavar for RNF25 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1057516786 likely-pathogenic, GRACILE syndrome 218,663,369(-) GAG/G downstream_transcript_variant
rs1000024451 -- 218,665,470(-) G/A intron_variant
rs1000055970 -- 218,669,337(-) T/C intron_variant
rs1000621972 -- 218,667,263(-) TCT/T intron_variant
rs1000909845 -- 218,666,822(-) T/C intron_variant

Variation tolerance for RNF25 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNF25 Gene

Disorders for RNF25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital epulis
  • congenital epulides
- elite association - COSMIC cancer census association via MalaCards
Search RNF25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RNF25

genes like me logo Genes that share disorders with RNF25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF25 Gene

Publications for RNF25 Gene

  1. RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. (PMID: 12748188) Asamitsu K … Okamoto T (The Journal of biological chemistry 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PMID: 10500182) Lorick KL … Weissman AM (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RNF25 Gene

Sources for RNF25 Gene

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