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Aliases for RAB17 Gene

Aliases for RAB17 Gene

  • RAB17, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-17 3

External Ids for RAB17 Gene

Previous GeneCards Identifiers for RAB17 Gene

  • GC02M236532
  • GC02M237164
  • GC02M238499
  • GC02M238769
  • GC02M238264
  • GC02M238147
  • GC02M230273

Summaries for RAB17 Gene

Entrez Gene Summary for RAB17 Gene

  • The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

GeneCards Summary for RAB17 Gene

RAB17 (RAB17, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5A.

UniProtKB/Swiss-Prot for RAB17 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.

Gene Wiki entry for RAB17 Gene

Additional gene information for RAB17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB17 Gene

Genomics for RAB17 Gene

GeneHancer (GH) Regulatory Elements for RAB17 Gene

Promoters and enhancers for RAB17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J237588 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 663.8 +9.5 9528 7.8 PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 FOS SP5 RAB17 LOC105373958 RNU6-1140P PRLH MLPH RAMP1 TRAF3IP1
GH02J237599 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 656 -0.8 -757 5.3 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 NFKBIZ RXRA RAB17 PIR37838 LRRFIP1 PIR33254
GH02J237685 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 -90.8 -90770 13.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 LRRFIP1 ILKAP RAB17 LOC105373958 RNU6-1140P PRLH RBM44 ESPNL UBE2F PIR56300
GH02J237624 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.3 -27.4 -27403 9.9 ELF3 PKNOX1 ARID4B SIN3A RAD21 THRB RARA YY1 ZNF335 RXRA LRRFIP1 RAB17 LOC105373958 ENSG00000227107 RBM44 PIR56300
GH02J237581 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.1 +19.5 19547 1.5 FOXA2 ZFP64 ARID4B THRB RAD21 RARA YY1 GLIS2 SCRT2 ZNF143 RAB17 MLPH LOC105373958 PRLH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB17 gene promoter:
  • TBP
  • Lmo2
  • FOXL1
  • Msx-1
  • AP-1
  • NF-E2
  • NF-E2 p45
  • LCR-F1

Genomic Locations for RAB17 Gene

Genomic Locations for RAB17 Gene
chr2:237,574,322-237,601,614
(GRCh38/hg38)
Size:
27,293 bases
Orientation:
Minus strand
chr2:238,482,965-238,510,257
(GRCh37/hg19)
Size:
27,293 bases
Orientation:
Minus strand

Genomic View for RAB17 Gene

Genes around RAB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB17 Gene

Proteins for RAB17 Gene

  • Protein details for RAB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0T7-RAB17_HUMAN
    Recommended name:
    Ras-related protein Rab-17
    Protein Accession:
    Q9H0T7
    Secondary Accessions:
    • Q53QV6
    • Q6IA73
    • Q6PJZ0
    • Q9BVU1
    • Q9H9U9

    Protein attributes for RAB17 Gene

    Size:
    212 amino acids
    Molecular mass:
    23491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB17 Gene

Post-translational modifications for RAB17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB17 Gene

Domains & Families for RAB17 Gene

Gene Families for RAB17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB17 Gene

Suggested Antigen Peptide Sequences for RAB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0T7

UniProtKB/Swiss-Prot:

RAB17_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB17: view

Function for RAB17 Gene

Molecular function for RAB17 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
UniProtKB/Swiss-Prot Induction:
Up-regulated by forskolin probably through the transcription factor MITF.

Phenotypes From GWAS Catalog for RAB17 Gene

Gene Ontology (GO) - Molecular Function for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,IDA 17646400
GO:0005515 protein binding IPI 17646400
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB17: view
genes like me logo Genes that share phenotypes with RAB17: view

Animal Models for RAB17 Gene

MGI Knock Outs for RAB17:
  • Rab17 Rab17<tm1a(KOMP)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for RAB17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB17 Gene

Localization for RAB17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB17 Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cell projection, dendrite. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000250 UniProtKB:P35292}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB17 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
mitochondrion 3
cytosol 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IBA --
GO:0005886 plasma membrane IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with RAB17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB17 Gene

Pathways & Interactions for RAB17 Gene

genes like me logo Genes that share pathways with RAB17: view

Pathways by source for RAB17 Gene

Gene Ontology (GO) - Biological Process for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISS --
GO:0006886 intracellular protein transport IBA --
GO:0015031 protein transport IEA --
GO:0030100 regulation of endocytosis IBA --
GO:0032401 establishment of melanosome localization ISS --
genes like me logo Genes that share ontologies with RAB17: view

No data available for SIGNOR curated interactions for RAB17 Gene

Drugs & Compounds for RAB17 Gene

No Compound Related Data Available

Transcripts for RAB17 Gene

Unigene Clusters for RAB17 Gene

RAB17, member RAS oncogene family:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAB17

Alternative Splicing Database (ASD) splice patterns (SP) for RAB17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for RAB17 Gene

GeneLoc Exon Structure for
RAB17
ECgene alternative splicing isoforms for
RAB17

Expression for RAB17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB17 Gene

This gene is overexpressed in Liver (x15.2) and Kidney - Cortex (x8.0).

Protein differential expression in normal tissues from HIPED for RAB17 Gene

This gene is overexpressed in Cervix (28.6), Fetal Brain (9.0), Urine (8.4), and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB17 Gene



Protein tissue co-expression partners for RAB17 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB17 Gene:

RAB17

SOURCE GeneReport for Unigene cluster for RAB17 Gene:

Hs.44278

mRNA Expression by UniProt/SwissProt for RAB17 Gene:

Q9H0T7-RAB17_HUMAN
Tissue specificity: Expressed in melanocytes (at protein level).

Evidence on tissue expression from TISSUES for RAB17 Gene

  • Liver(4.4)
  • Nervous system(4.2)
  • Intestine(4.1)
  • Eye(4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RAB17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB17 Gene

Orthologs for RAB17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB17 34 33
  • 98.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAB17 34 33
  • 81.13 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab17 33
  • 79.15 (n)
mouse
(Mus musculus)
Mammalia Rab17 16 34 33
  • 77.99 (n)
cow
(Bos Taurus)
Mammalia RAB17 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB17 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB17 34 33
  • 64.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB17 34
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta chrw 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
Species where no ortholog for RAB17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB17 Gene

ENSEMBL:
Gene Tree for RAB17 (if available)
TreeFam:
Gene Tree for RAB17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB17: view image

Paralogs for RAB17 Gene

genes like me logo Genes that share paralogs with RAB17: view

Variants for RAB17 Gene

Sequence variations from dbSNP and Humsavar for RAB17 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000439438 -- 237,577,684(-) C/T intron_variant
rs1000756868 -- 237,589,718(-) T/C intron_variant
rs1000831868 -- 237,590,367(-) A/G intron_variant
rs1000875399 -- 237,588,418(-) A/G intron_variant
rs1001027725 -- 237,579,090(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB17 Gene

Variant ID Type Subtype PubMed ID
dgv4192n100 CNV loss 25217958
esv28512 CNV loss 19812545
nsv1000252 CNV loss 25217958
nsv1010093 CNV gain 25217958
nsv3229 CNV deletion 18451855

Variation tolerance for RAB17 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB17 Gene

Disorders for RAB17 Gene

Additional Disease Information for RAB17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB17 Gene

Publications for RAB17 Gene

  1. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. (PMID: 22328529) von Thun A … Norman JC (Journal of cell science 2012) 3 4 58
  2. The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. (PMID: 21291502) Beaumont KA … Stow JL (Traffic (Copenhagen, Denmark) 2011) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RAB17 Gene

Sources for RAB17 Gene

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