Aliases for SFRP2 Gene
External Ids for SFRP2 Gene
Previous GeneCards Identifiers for SFRP2 Gene
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP2 Gene
SFRP2 (Secreted Frizzled Related Protein 2) is a Protein Coding gene. Diseases associated with SFRP2 include Esophageal Basaloid Squamous Cell Carcinoma and Colorectal Cancer. Among its related pathways are Signaling by Wnt and Negative regulation of TCF-dependent signaling by WNT ligand antagonists. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is SFRP5.
UniProtKB/Swiss-Prot for SFRP2 Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.