External Ids for SEMG2 Gene
Previous GeneCards Identifiers for SEMG2 Gene
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]
GeneCards Summary for SEMG2 Gene
SEMG2 (Semenogelin II) is a Protein Coding gene. Diseases associated with SEMG2 include Pelvic Varices. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG1.
UniProtKB/Swiss-Prot for SEMG2 Gene
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.