Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEMG2 Gene

Aliases for SEMG2 Gene

  • Semenogelin II 2 3 4 5
  • Semenogelin 2 2 3
  • SgII 3 4
  • Semenogelin-2 3

External Ids for SEMG2 Gene

Previous GeneCards Identifiers for SEMG2 Gene

  • GC20P043578
  • GC20P044488
  • GC20P044535
  • GC20P043283
  • GC20P043849
  • GC20P040591

Summaries for SEMG2 Gene

Entrez Gene Summary for SEMG2 Gene

  • The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]

GeneCards Summary for SEMG2 Gene

SEMG2 (Semenogelin II) is a Protein Coding gene. Diseases associated with SEMG2 include Pelvic Varices. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG1.

UniProtKB/Swiss-Prot for SEMG2 Gene

  • Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.

Gene Wiki entry for SEMG2 Gene

Additional gene information for SEMG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMG2 Gene

Genomics for SEMG2 Gene

GeneHancer (GH) Regulatory Elements for SEMG2 Gene

Promoters and enhancers for SEMG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045221 Promoter 0.5 EPDnew 550.8 +0.1 54 0.1 SEMG2 GC20P045227
GH20I045206 Promoter 0.5 EPDnew 0.4 -14.3 -14285 0.1 SEMG1 SLPI SEMG2
GH20I045209 Enhancer 0.4 ENCODE 0.4 -11.2 -11235 0.2 USF1 POU5F1 SEMG1 SEMG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEMG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEMG2 gene promoter:

Genomic Locations for SEMG2 Gene

Genomic Locations for SEMG2 Gene
3,159 bases
Plus strand

Genomic View for SEMG2 Gene

Genes around SEMG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMG2 Gene

Proteins for SEMG2 Gene

  • Protein details for SEMG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q53ZU2
    • Q6X2M5
    • Q6X2M6

    Protein attributes for SEMG2 Gene

    582 amino acids
    Molecular mass:
    65444 Da
    Quaternary structure:
    • Interacts with SERPINA5.

neXtProt entry for SEMG2 Gene

Post-translational modifications for SEMG2 Gene

  • Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide.
  • Glycosylation at isoforms=272
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMG2 Gene

Domains & Families for SEMG2 Gene

Gene Families for SEMG2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SEMG2 Gene


Suggested Antigen Peptide Sequences for SEMG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the semenogelin family.
  • Belongs to the semenogelin family.
genes like me logo Genes that share domains with SEMG2: view

Function for SEMG2 Gene

Molecular function for SEMG2 Gene

GENATLAS Biochemistry:
major protein of seminal fluid,semenogelin 2 (71 and 76 kDa)
UniProtKB/Swiss-Prot Function:
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.

Gene Ontology (GO) - Molecular Function for SEMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 8665956
GO:0005515 protein binding IPI 8665956
GO:0046872 metal ion binding IMP 15563730
genes like me logo Genes that share ontologies with SEMG2: view
genes like me logo Genes that share phenotypes with SEMG2: view

miRNA for SEMG2 Gene

miRTarBase miRNAs that target SEMG2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMG2 Gene

Localization for SEMG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMG2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMG2 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SEMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 1517240
GO:0005634 nucleus IDA,HDA 21630459
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with SEMG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEMG2 Gene

Pathways & Interactions for SEMG2 Gene

SuperPathways for SEMG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019731 antibacterial humoral response IMP 18714013
GO:0050817 coagulation IDA 8665956
GO:0051291 protein heterooligomerization IDA 8665956
GO:1900005 positive regulation of serine-type endopeptidase activity IDA 15563730
GO:1901318 negative regulation of flagellated sperm motility IEA --
genes like me logo Genes that share ontologies with SEMG2: view

No data available for Pathways by source and SIGNOR curated interactions for SEMG2 Gene

Drugs & Compounds for SEMG2 Gene

(2) Drugs for SEMG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SEMG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SEMG2: view

Transcripts for SEMG2 Gene

mRNA/cDNA for SEMG2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(344) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEMG2 Gene

Semenogelin II:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMG2 Gene

No ASD Table

Relevant External Links for SEMG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEMG2 Gene

mRNA differential expression in normal tissues according to GTEx for SEMG2 Gene

This gene is overexpressed in Prostate (x32.5), Kidney - Cortex (x9.0), and Testis (x4.6).

Protein differential expression in normal tissues from HIPED for SEMG2 Gene

This gene is overexpressed in Prostate (51.8) and Seminal vesicle (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMG2 Gene

Protein tissue co-expression partners for SEMG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMG2 Gene:


SOURCE GeneReport for Unigene cluster for SEMG2 Gene:


mRNA Expression by UniProt/SwissProt for SEMG2 Gene:

Tissue specificity: Seminal vesicles, and to a much lesser extent, epididymis.
genes like me logo Genes that share expression patterns with SEMG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMG2 Gene

Orthologs for SEMG2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SEMG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEMG2 33
  • 98.03 (n)
Species where no ortholog for SEMG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEMG2 Gene

Gene Tree for SEMG2 (if available)
Gene Tree for SEMG2 (if available)

Paralogs for SEMG2 Gene

Paralogs for SEMG2 Gene

(1) SIMAP similar genes for SEMG2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMG2: view

Variants for SEMG2 Gene

Sequence variations from dbSNP and Humsavar for SEMG2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1001057447 -- 45,224,299(+) C/T 3_prime_UTR_variant
rs1001330971 -- 45,224,394(+) T/A 3_prime_UTR_variant
rs1001966331 -- 45,220,979(+) A/C upstream_transcript_variant
rs1002034264 -- 45,219,707(+) T/A upstream_transcript_variant
rs1003112003 -- 45,221,234(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEMG2 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for SEMG2 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEMG2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMG2 Gene

Disorders for SEMG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEMG2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search SEMG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SEMG2

genes like me logo Genes that share disorders with SEMG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMG2 Gene

Publications for SEMG2 Gene

  1. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PMID: 14629036) Jensen-Seaman MI … Li WH (Journal of molecular evolution 2003) 3 4 22 58
  2. Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase. (PMID: 9523691) Peter A … Malm J (European journal of biochemistry 1998) 2 3 22 58
  3. Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. (PMID: 8665951) Malm J … Lilja H (European journal of biochemistry 1996) 3 4 22 58
  4. Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. (PMID: 8665956) Kise H … Suzuki K (European journal of biochemistry 1996) 3 4 22 58
  5. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. (PMID: 1517240) Ulvsbäck M … Lundwall A (The Journal of biological chemistry 1992) 2 3 4 58

Products for SEMG2 Gene

Sources for SEMG2 Gene

Loading form....