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Aliases for TP53AIP1 Gene

Aliases for TP53AIP1 Gene

  • Tumor Protein P53 Regulated Apoptosis Inducing Protein 1 2 3 5
  • P53AIP1 3 4
  • P53-Regulated Apoptosis-Inducing Protein 1 3

External Ids for TP53AIP1 Gene

Previous GeneCards Identifiers for TP53AIP1 Gene

  • GC11M128313
  • GC11M128805
  • GC11M124756

Summaries for TP53AIP1 Gene

Entrez Gene Summary for TP53AIP1 Gene

  • This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TP53AIP1 Gene

TP53AIP1 (Tumor Protein P53 Regulated Apoptosis Inducing Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and DNA Damage Response.

UniProtKB/Swiss-Prot for TP53AIP1 Gene

  • May play an important role in mediating p53/TP53-dependent apoptosis.

Gene Wiki entry for TP53AIP1 Gene

Additional gene information for TP53AIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53AIP1 Gene

Genomics for TP53AIP1 Gene

GeneHancer (GH) Regulatory Elements for TP53AIP1 Gene

Promoters and enhancers for TP53AIP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J128942 Promoter 0.5 EPDnew 650.7 +0.5 524 0.1 TP53AIP1 GC11P128919
GH11J128890 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +50.2 50209 5.2 ELF3 ZSCAN4 MZF1 ZNF2 YY1 ZNF335 TCF12 ZNF121 GLIS2 EGR1 KCNJ5 GC11M128892 TP53AIP1 C11orf45
GH11J128904 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 12.2 +37.7 37723 2 CTCF KLF1 PKNOX1 KLF17 EBF1 ZIC2 RAD21 ZNF335 ZFHX2 GLIS2 C11orf45 TP53AIP1 KCNJ5 GC11M128892
GH11J128884 Enhancer 0.6 ENCODE 12 +58.5 58508 0.2 CTCF ZNF654 MAX TRIM22 REST RAD21 RFX5 ZNF143 SMC3 MYC TP53AIP1 ENSG00000255369 KCNJ5
GH11J128964 Enhancer 0.5 ENCODE 12 -21.2 -21159 0.9 SCRT2 FEZF1 ZIC2 ZNF18 KCNJ5 TP53AIP1 C11orf45 GC11P128967 GC11P128954
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TP53AIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TP53AIP1 gene promoter:
  • Pax-2a
  • Pax-2
  • Pax-6
  • FOXD3
  • HSF1short
  • HSF1 (long)
  • POU2F1a
  • POU2F1
  • YY1
  • C/EBPbeta

Genomic Locations for TP53AIP1 Gene

Genomic Locations for TP53AIP1 Gene
8,669 bases
Minus strand
8,669 bases
Minus strand

Genomic View for TP53AIP1 Gene

Genes around TP53AIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53AIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53AIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53AIP1 Gene

Proteins for TP53AIP1 Gene

  • Protein details for TP53AIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    p53-regulated apoptosis-inducing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6NT40
    • Q7Z6F7
    • Q9HCN0
    • Q9HCN1

    Protein attributes for TP53AIP1 Gene

    124 amino acids
    Molecular mass:
    12935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TP53AIP1 Gene


neXtProt entry for TP53AIP1 Gene

Post-translational modifications for TP53AIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TP53AIP1 Gene

Domains & Families for TP53AIP1 Gene

Gene Families for TP53AIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TP53AIP1 Gene


Suggested Antigen Peptide Sequences for TP53AIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP53AIP1: view

No data available for UniProtKB/Swiss-Prot for TP53AIP1 Gene

Function for TP53AIP1 Gene

Molecular function for TP53AIP1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in mediating p53/TP53-dependent apoptosis.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes From GWAS Catalog for TP53AIP1 Gene

Gene Ontology (GO) - Molecular Function for TP53AIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TP53AIP1: view
genes like me logo Genes that share phenotypes with TP53AIP1: view

Animal Model Products

miRNA for TP53AIP1 Gene

miRTarBase miRNAs that target TP53AIP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53AIP1 Gene

Localization for TP53AIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53AIP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53AIP1 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TP53AIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 11030628
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with TP53AIP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TP53AIP1 Gene

Pathways & Interactions for TP53AIP1 Gene

genes like me logo Genes that share pathways with TP53AIP1: view

Interacting Proteins for TP53AIP1 Gene

Gene Ontology (GO) - Biological Process for TP53AIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 11030628
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with TP53AIP1: view

No data available for SIGNOR curated interactions for TP53AIP1 Gene

Drugs & Compounds for TP53AIP1 Gene

(4) Drugs for TP53AIP1 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3113
Epirubicin Approved Pharma 426
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1970
genes like me logo Genes that share compounds with TP53AIP1: view

Transcripts for TP53AIP1 Gene

Unigene Clusters for TP53AIP1 Gene

Tumor protein p53 regulated apoptosis inducing protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53AIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: - - - - -
SP3: - - -
SP5: -

Relevant External Links for TP53AIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TP53AIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53AIP1 Gene

mRNA differential expression in normal tissues according to GTEx for TP53AIP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.1), Skin - Not Sun Exposed (Suprapubic) (x9.7), Skin - Sun Exposed (Lower leg) (x8.4), and Vagina (x6.8).

NURSA nuclear receptor signaling pathways regulating expression of TP53AIP1 Gene:


SOURCE GeneReport for Unigene cluster for TP53AIP1 Gene:


mRNA Expression by UniProt/SwissProt for TP53AIP1 Gene:

Tissue specificity: Only found to be expressed in thymus.
genes like me logo Genes that share expression patterns with TP53AIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53AIP1 Gene

Orthologs for TP53AIP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TP53AIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TP53AIP1 34 33
  • 98.66 (n)
Species where no ortholog for TP53AIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TP53AIP1 Gene

Gene Tree for TP53AIP1 (if available)
Gene Tree for TP53AIP1 (if available)
Evolutionary constrained regions (ECRs) for TP53AIP1: view image

Paralogs for TP53AIP1 Gene

(1) SIMAP similar genes for TP53AIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TP53AIP1: view

No data available for Paralogs for TP53AIP1 Gene

Variants for TP53AIP1 Gene

Sequence variations from dbSNP and Humsavar for TP53AIP1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000012854 -- 128,937,139(-) C/A/G/T 3_prime_UTR_variant, intron_variant, splice_donor_variant
rs1000821371 -- 128,945,246(-) G/T upstream_transcript_variant
rs1000848478 -- 128,941,285(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1001007330 -- 128,936,068(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001263583 -- 128,942,076(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TP53AIP1 Gene

Variant ID Type Subtype PubMed ID
dgv84n21 CNV loss 19592680
esv2097474 CNV deletion 18987734
nsv468892 CNV loss 19166990
nsv556563 CNV loss 21841781

Variation tolerance for TP53AIP1 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP53AIP1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53AIP1 Gene

Disorders for TP53AIP1 Gene

Additional Disease Information for TP53AIP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TP53AIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53AIP1 Gene

Publications for TP53AIP1 Gene

  1. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. (PMID: 11030628) Oda K … Taya Y (Cell 2000) 2 3 4 22 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. (PMID: 15657359) Wesierska-Gadek J … Horky M (Molecular cancer therapeutics 2005) 3 22 58
  4. p53AIP1 regulates the mitochondrial apoptotic pathway. (PMID: 12019168) Matsuda K … Arakawa H (Cancer research 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TP53AIP1 Gene

Sources for TP53AIP1 Gene

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