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Aliases for UBE2O Gene

Aliases for UBE2O Gene

  • Ubiquitin Conjugating Enzyme E2 O 2 3 5
  • E2/E3 Hybrid Ubiquitin-Protein Ligase UBE2O 3 4
  • Ubiquitin-Conjugating Enzyme E2 Of 230 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-230K 3 4
  • Ubiquitin Carrier Protein O 3 4
  • Ubiquitin-Protein Ligase O 3 4
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme E2 O 4
  • Ubiquitin-Conjugating Enzyme E2O 2
  • Ubiquitin Conjugating Enzyme E2O 3
  • EC 2.3.2.24 4
  • KIAA1734 4
  • E2-230K 3

External Ids for UBE2O Gene

Previous GeneCards Identifiers for UBE2O Gene

  • GC17M071898
  • GC17M074385
  • GC17M069814

Summaries for UBE2O Gene

GeneCards Summary for UBE2O Gene

UBE2O (Ubiquitin Conjugating Enzyme E2 O) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is BIRC6.

UniProtKB/Swiss-Prot for UBE2O Gene

  • E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Gene Wiki entry for UBE2O Gene

Additional gene information for UBE2O Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2O Gene

Genomics for UBE2O Gene

GeneHancer (GH) Regulatory Elements for UBE2O Gene

Promoters and enhancers for UBE2O Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I076452 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 215 2 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF207 UBE2O AANAT SPHK1 GC17M076452 GC17P076430
GH17I075975 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.9 +473.0 473012 10.1 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 ACOX1 TEN1 TEN1-CDK3 SRSF2 UBE2O H3F3B UNK ENSG00000267342 GGA3 SAP30BP
GH17I075763 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 12.9 +688.1 688122 2.7 HDGF PKNOX1 ARNT MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B GALK1 UBE2O FBF1 UNC13D ENSG00000267342 GC17M075747
GH17I076352 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +99.2 99174 2.9 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PRPSAP1 UNK SRSF2 ENSG00000266980 SEPT9 MFSD11 METTL23 EXOC7 QRICH2 SPHK1
GH17I076480 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -30.1 -30133 6.1 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF2 IRF4 YY1 SLC30A9 UNK SRSF2 TRIM65 ENSG00000267342 ENSG00000267801 RHBDF2 AANAT CDK3 UBE2O SAP30BP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBE2O on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2O gene promoter:

Genomic Locations for UBE2O Gene

Genomic Locations for UBE2O Gene
chr17:76,389,451-76,453,206
(GRCh38/hg38)
Size:
63,756 bases
Orientation:
Minus strand
chr17:74,385,532-74,449,288
(GRCh37/hg19)

Genomic View for UBE2O Gene

Genes around UBE2O on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2O Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2O Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2O Gene

Proteins for UBE2O Gene

  • Protein details for UBE2O Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C9-UBE2O_HUMAN
    Recommended name:
    (E3-independent) E2 ubiquitin-conjugating enzyme
    Protein Accession:
    Q9C0C9
    Secondary Accessions:
    • A6NDU5
    • Q69YP4
    • Q6PIZ2
    • Q86UA4
    • Q8N425
    • Q8TBN1
    • Q9BSW1
    • Q9H6E6
    • Q9H7E4
    • Q9H9B2

    Protein attributes for UBE2O Gene

    Size:
    1292 amino acids
    Molecular mass:
    141293 Da
    Quaternary structure:
    • Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain).
    SequenceCaution:
    • Sequence=AAH22237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25977.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH36820.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH51868.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14320.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15313.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UBE2O Gene

Post-translational modifications for UBE2O Gene

  • Phosphorylated. Phosphorylation affects subcellular location.
  • Ubiquitinated: autoubiquitinates, possibly affecting its subcellular location.
  • Ubiquitination at isoforms=132, isoforms=212, isoforms=283, posLast=373373, posLast=521521, posLast=620620, posLast=815815, posLast=819819, isoforms=825, isoforms=866, and posLast=990990
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2O Gene

No data available for DME Specific Peptides for UBE2O Gene

Domains & Families for UBE2O Gene

Gene Families for UBE2O Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2O Gene

Suggested Antigen Peptide Sequences for UBE2O Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0C9

UniProtKB/Swiss-Prot:

UBE2O_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2O: view

Function for UBE2O Gene

Molecular function for UBE2O Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
inhibited by phenylarsine oxide (PAO).
UniProtKB/Swiss-Prot Function:
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Enzyme Numbers (IUBMB) for UBE2O Gene

Phenotypes From GWAS Catalog for UBE2O Gene

Gene Ontology (GO) - Molecular Function for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22681889
GO:0004842 ubiquitin-protein transferase activity IDA 23455153
GO:0005515 protein binding IPI 23455153
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2O: view
genes like me logo Genes that share phenotypes with UBE2O: view

Animal Models for UBE2O Gene

MGI Knock Outs for UBE2O:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2O

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2O Gene

Localization for UBE2O Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2O Gene

Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2O gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24703950
GO:0005737 cytoplasm IDA 24703950
GO:0005829 cytosol IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with UBE2O: view

Pathways & Interactions for UBE2O Gene

genes like me logo Genes that share pathways with UBE2O: view

UniProtKB/Swiss-Prot Q9C0C9-UBE2O_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2O Gene

Inactivates:

Gene Ontology (GO) - Biological Process for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IDA 23455153
GO:0006810 transport IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030513 positive regulation of BMP signaling pathway IDA 23455153
GO:0042147 retrograde transport, endosome to Golgi IMP 23452853
genes like me logo Genes that share ontologies with UBE2O: view

Drugs & Compounds for UBE2O Gene

(3) Drugs for UBE2O Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for UBE2O Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2O: view

Transcripts for UBE2O Gene

Unigene Clusters for UBE2O Gene

Ubiquitin-conjugating enzyme E2O:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for UBE2O Gene

GeneLoc Exon Structure for
UBE2O
ECgene alternative splicing isoforms for
UBE2O

Expression for UBE2O Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2O Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2O Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8) and Heart (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2O Gene



Protein tissue co-expression partners for UBE2O Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2O Gene:

UBE2O

SOURCE GeneReport for Unigene cluster for UBE2O Gene:

Hs.16130

mRNA Expression by UniProt/SwissProt for UBE2O Gene:

Q9C0C9-UBE2O_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle and heart.

Evidence on tissue expression from TISSUES for UBE2O Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Skin(4.2)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with UBE2O: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2O Gene

Orthologs for UBE2O Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2O Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2O 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia UBE2O 33 34
  • 90.83 (n)
cow
(Bos Taurus)
Mammalia UBE2O 33 34
  • 90.48 (n)
rat
(Rattus norvegicus)
Mammalia Ube2o 33
  • 88.92 (n)
mouse
(Mus musculus)
Mammalia Ube2o 33 16 34
  • 88.55 (n)
oppossum
(Monodelphis domestica)
Mammalia UBE2O 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2O 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2O 33 34
  • 77.46 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2O 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2o 33
  • 70.17 (n)
zebrafish
(Danio rerio)
Actinopterygii UBE2O 34
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10254 34
  • 25 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.2300 33
corn
(Zea mays)
Liliopsida Zm.2040 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for UBE2O was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2O Gene

ENSEMBL:
Gene Tree for UBE2O (if available)
TreeFam:
Gene Tree for UBE2O (if available)

Paralogs for UBE2O Gene

Paralogs for UBE2O Gene

(5) SIMAP similar genes for UBE2O Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBE2O: view

Variants for UBE2O Gene

Sequence variations from dbSNP and Humsavar for UBE2O Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000048822 -- 76,400,869(-) C/T intron_variant
rs1000086364 -- 76,444,400(-) A/T intron_variant
rs1000119220 -- 76,423,373(-) C/G intron_variant
rs1000166377 -- 76,422,330(-) C/T intron_variant
rs1000171761 -- 76,428,325(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2O Gene

Variant ID Type Subtype PubMed ID
esv3397284 CNV duplication 20981092
esv3399280 CNV duplication 20981092
esv3582913 CNV loss 25503493
esv3641287 CNV loss 21293372
esv3641288 CNV loss 21293372
esv3641289 CNV insertion 21293372
nsv1143862 CNV deletion 24896259
nsv2145 CNV deletion 18451855
nsv833547 CNV loss 17160897
nsv833549 CNV gain 17160897
nsv978463 CNV duplication 23825009

Variation tolerance for UBE2O Gene

Residual Variation Intolerance Score: 5.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.80; 93.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2O Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2O

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2O Gene

Disorders for UBE2O Gene

Additional Disease Information for UBE2O

No disorders were found for UBE2O Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2O Gene

Publications for UBE2O Gene

  1. Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PMID: 11311559) Yokota T … Emi M (Gene 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. (PMID: 24703950) Mashtalir N … Affar el B (Molecular cell 2014) 3 4 58
  4. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. (PMID: 23381138) Zhang X … ten Dijke P (Cell research 2013) 3 4 58
  5. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. (PMID: 23452853) Hao YH … Potts PR (Cell 2013) 3 4 58

Products for UBE2O Gene

Sources for UBE2O Gene

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