Aliases for SDC2 Gene
External Ids for SDC2 Gene
Previous HGNC Symbols for SDC2 Gene
Previous GeneCards Identifiers for SDC2 Gene
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
GeneCards Summary for SDC2 Gene
SDC2 (Syndecan 2) is a Protein Coding gene. Diseases associated with SDC2 include Neurofibromatosis, Type I and Trichorhinophalangeal Syndrome, Type I. Among its related pathways are Cell adhesion_ECM remodeling and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and cytoskeletal protein binding. An important paralog of this gene is SDC3.
UniProtKB/Swiss-Prot for SDC2 Gene
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).