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Aliases for CCL5 Gene

Aliases for CCL5 Gene

  • C-C Motif Chemokine Ligand 5 2 3 5
  • SIS-Delta 2 3 4
  • Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted 2 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5 2 3
  • Eosinophil Chemotactic Cytokine 3 4
  • Chemokine (C-C Motif) Ligand 5 2 3
  • T-Cell Specific Protein P288 2 3
  • Beta-Chemokine RANTES 2 3
  • D17S136E 3 4
  • TCP228 3 4
  • SCYA5 3 4
  • EoCP 3 4
  • Small Inducible Cytokine A5 (RANTES) 2
  • T-Cell-Specific Protein RANTES 4
  • T-Cell Specific RANTES Protein 2
  • T Cell-Specific Protein P228 4
  • Small-Inducible Cytokine A5 4
  • C-C Motif Chemokine 5 3
  • RANTES 3
  • SISd 3

External Ids for CCL5 Gene

Previous HGNC Symbols for CCL5 Gene

  • D17S136E
  • SCYA5

Previous GeneCards Identifiers for CCL5 Gene

  • GC17M033968
  • GC17M036234
  • GC17M034344
  • GC17M031222
  • GC17M034198
  • GC17M030383

Summaries for CCL5 Gene

Entrez Gene Summary for CCL5 Gene

  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CCL5 Gene

CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Ulcer Of Lower Limbs and Periapical Granuloma. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL3L1.

UniProtKB/Swiss-Prot for CCL5 Gene

  • Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Gene Wiki entry for CCL5 Gene

Additional gene information for CCL5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL5 Gene

Genomics for CCL5 Gene

GeneHancer (GH) Regulatory Elements for CCL5 Gene

Promoters and enhancers for CCL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J035878 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.9 898 3.2 HDGF PKNOX1 SMAD1 RB1 BATF KLF5 ZNF143 ATF7 ETV6 BCLAF1 CCL5 C17orf50 TAF15 GAS2L2 LOC105371744 ENSG00000270240
GH17J035894 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.4 -13.5 -13500 0.1 ZNF680 CCL5 GC17M035888 PIR57610 GC17M035909 LRRC37A8P
GH17J035533 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +343.1 343120 9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZNF2 IRF4 YY1 ARID2 ZNF143 SLFN12L AP2B1 CCL5 ZNF830 PEX12 LIG3 SLFN5 TAF5LP1 GAS2L2 SLFN11
GH17J036102 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 13.6 -225.2 -225212 6.2 PKNOX1 ATF1 SMAD1 KLF17 BMI1 SCRT2 ZNF143 ATF7 IKZF2 RUNX3 CCL4 CCL3 CCL3L1 CCL3L3 CCL5 CCL18 CCL15 PIGW SLFN12L MYO19
GH17J035930 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.4 -50.1 -50065 1.3 HDGF ATF1 SIN3A ETS1 POLR2B ZNF207 ATF7 RUNX3 SP3 MXD4 RDM1 LIG3 GAS2L2 CCL5 ZNF830 C17orf50 AP2B1 GC17M036129
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL5 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for CCL5 Gene

Genomic Locations for CCL5 Gene
chr17:35,871,491-35,880,793
(GRCh38/hg38)
Size:
9,303 bases
Orientation:
Minus strand
chr17:34,198,495-34,207,797
(GRCh37/hg19)
Size:
9,303 bases
Orientation:
Minus strand

Genomic View for CCL5 Gene

Genes around CCL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL5 Gene

Proteins for CCL5 Gene

  • Protein details for CCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13501-CCL5_HUMAN
    Recommended name:
    C-C motif chemokine 5
    Protein Accession:
    P13501
    Secondary Accessions:
    • O43646
    • Q0QVW8
    • Q4ZGJ1
    • Q9NYA2
    • Q9UBG2
    • Q9UC99

    Protein attributes for CCL5 Gene

    Size:
    91 amino acids
    Molecular mass:
    9990 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL5 Gene

neXtProt entry for CCL5 Gene

Post-translational modifications for CCL5 Gene

  • N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
  • The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
  • Glycosylation at posLast=2828 and posLast=2727
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL5 Gene

Antibody Products

  • Abcam antibodies for CCL5

No data available for DME Specific Peptides for CCL5 Gene

Domains & Families for CCL5 Gene

Gene Families for CCL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CCL5 Gene

Graphical View of Domain Structure for InterPro Entry

P13501

UniProtKB/Swiss-Prot:

CCL5_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL5: view

Function for CCL5 Gene

Molecular function for CCL5 Gene

UniProtKB/Swiss-Prot Function:
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
UniProtKB/Swiss-Prot Induction:
By mitogens.

Phenotypes From GWAS Catalog for CCL5 Gene

Gene Ontology (GO) - Molecular Function for CCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IDA 10734056
GO:0004672 protein kinase activity IDA 10734056
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 8699119
GO:0008009 chemokine activity NAS,IEA 7524281
genes like me logo Genes that share ontologies with CCL5: view
genes like me logo Genes that share phenotypes with CCL5: view

Animal Models for CCL5 Gene

MGI Knock Outs for CCL5:

Animal Model Products

Clone Products

  • Addgene plasmids for CCL5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL5 Gene

Localization for CCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL5 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
endosome 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA,IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL5 Gene

Pathways & Interactions for CCL5 Gene

genes like me logo Genes that share pathways with CCL5: view

Gene Ontology (GO) - Biological Process for CCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0002407 dendritic cell chemotaxis TAS 18337562
GO:0002548 monocyte chemotaxis IC 10660125
GO:0002676 regulation of chronic inflammatory response TAS 10488085
GO:0006816 calcium ion transport IDA 10734056
genes like me logo Genes that share ontologies with CCL5: view

No data available for SIGNOR curated interactions for CCL5 Gene

Drugs & Compounds for CCL5 Gene

(71) Drugs for CCL5 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Disaccharide Iii-S Experimental Pharma Target 0
Heparin Disaccharide I-S Experimental Pharma Target 0

(48) Additional Compounds for CCL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL5: view

Transcripts for CCL5 Gene

mRNA/cDNA for CCL5 Gene

Unigene Clusters for CCL5 Gene

Chemokine (C-C motif) ligand 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCL5

Alternative Splicing Database (ASD) splice patterns (SP) for CCL5 Gene

No ASD Table

Relevant External Links for CCL5 Gene

GeneLoc Exon Structure for
CCL5
ECgene alternative splicing isoforms for
CCL5

Expression for CCL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL5 Gene

This gene is overexpressed in Whole Blood (x33.8).

Protein differential expression in normal tissues from HIPED for CCL5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.9), Platelet (15.1), Serum (14.1), and Monocytes (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL5 Gene



Protein tissue co-expression partners for CCL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCL5 Gene:

CCL5

SOURCE GeneReport for Unigene cluster for CCL5 Gene:

Hs.514821

mRNA Expression by UniProt/SwissProt for CCL5 Gene:

P13501-CCL5_HUMAN
Tissue specificity: Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.

Evidence on tissue expression from TISSUES for CCL5 Gene

  • Blood(4.8)
  • Nervous system(4.5)
  • Lung(3.4)
  • Lymph node(3.4)
  • Spleen(3.4)
  • Bone marrow(2.9)
  • Intestine(2.7)
  • Heart(2.5)
  • Kidney(2.5)
  • Liver(2.4)
  • Skin(2.4)
  • Stomach(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with CCL5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL5 Gene

Orthologs for CCL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL5 33
  • 100 (n)
rat
(Rattus norvegicus)
Mammalia Ccl5 33
  • 88.6 (n)
dog
(Canis familiaris)
Mammalia CCL5 33
  • 85.71 (n)
cow
(Bos Taurus)
Mammalia CCL5 33
  • 85.71 (n)
mouse
(Mus musculus)
Mammalia Ccl5 16 33
  • 85.35 (n)
chicken
(Gallus gallus)
Aves CCL5 33
  • 64.89 (n)
Species where no ortholog for CCL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL5 Gene

ENSEMBL:
Gene Tree for CCL5 (if available)
TreeFam:
Gene Tree for CCL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL5: view image

Paralogs for CCL5 Gene

Paralogs for CCL5 Gene

(30) SIMAP similar genes for CCL5 Gene using alignment to 3 proteins:

  • CCL5_HUMAN
  • D0EI67_HUMAN
  • K7EJM0_HUMAN
genes like me logo Genes that share paralogs with CCL5: view

Variants for CCL5 Gene

Sequence variations from dbSNP and Humsavar for CCL5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000156922 -- 35,881,789(-) C/T upstream_transcript_variant
rs1000165965 -- 35,871,362(-) G/A downstream_transcript_variant
rs1000599672 -- 35,873,370(-) G/A intron_variant
rs1000709472 -- 35,877,736(-) T/A intron_variant
rs1000762147 -- 35,880,441(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL5 Gene

Variant ID Type Subtype PubMed ID
esv3640458 CNV loss 21293372
esv3892999 CNV loss 25118596
nsv1059795 CNV gain 25217958
nsv1079030 OTHER inversion 25765185

Variation tolerance for CCL5 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL5 Gene

Human Gene Mutation Database (HGMD)
CCL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL5 Gene

Disorders for CCL5 Gene

MalaCards: The human disease database

(89) MalaCards diseases for CCL5 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ulcer of lower limbs
  • ulcer of ankle
periapical granuloma
  • apical granuloma
whiplash
viral meningitis
  • meningitis viral
genital herpes
  • genital herpes simplex
- elite association - COSMIC cancer census association via MalaCards
Search CCL5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL5 Gene

Publications for CCL5 Gene

  1. RANTES promoter genotype and gastric cancer risk in a Japanese population. (PMID: 19846984) Tahara T … Arisawa T (Anticancer research 2009) 3 22 44 58
  2. Analysis of CCR5, CCR2, SDF1 and RANTES gene polymorphisms in subjects with HIV-related PML and not determined leukoencephalopathy. (PMID: 17560067) Guerini FR … Ferrante P (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2008) 3 22 44 58
  3. Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. (PMID: 16323127) Shrestha S … Smith MW (The Journal of infectious diseases 2006) 3 22 44 58
  4. RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. (PMID: 17001303) Ignatov A … Schaller HC (British journal of pharmacology 2006) 3 4 22 58
  5. The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. (PMID: 15863470) Goulding C … Kelleher D (Gut 2005) 3 22 44 58

Products for CCL5 Gene

  • Addgene plasmids for CCL5

Sources for CCL5 Gene

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