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Aliases for SCT Gene

Aliases for SCT Gene

  • Secretin 2 3 3 5
  • Prepro-Secretin 2 3

External Ids for SCT Gene

Previous GeneCards Identifiers for SCT Gene

  • GC11P001116
  • GC11P000936
  • GC11P000573
  • GC11M000616
  • GC11M000441

Summaries for SCT Gene

Entrez Gene Summary for SCT Gene

  • This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]

GeneCards Summary for SCT Gene

SCT (Secretin) is a Protein Coding gene. Diseases associated with SCT include Zollinger-Ellison Syndrome and Gastrinoma. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for SCT Gene

  • Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

Gene Wiki entry for SCT Gene

Additional gene information for SCT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCT Gene

Genomics for SCT Gene

GeneHancer (GH) Regulatory Elements for SCT Gene

Promoters and enhancers for SCT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000628 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 658.6 -1.8 -1770 1.9 ATF1 PKNOX1 FEZF1 BATF KLF5 ZNF366 ATF7 IKZF2 RUNX3 CREM SCT TMEM80 DRD4 IRF7 GC11P000637
GH11J000627 Promoter 0.5 EPDnew 650.7 +0.0 39 0.1 CDHR5 SCT
GH11J000623 Promoter/Enhancer 1.2 EPDnew ENCODE 0.7 +2.1 2124 3.7 KLF1 SAP130 RAD21 RARA POLR2A SCRT2 ATF7 ZNF600 NR2F6 ZNF10 CDHR5 TMEM80 EPS8L2 ENSG00000254815 GC11M000619 SCT
GH11J000632 Enhancer 0.3 ENCODE 0.4 -5.7 -5720 0.8 ZNF18 GC11P000637 SCT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCT gene promoter:
  • Sp1
  • p300
  • C/EBPalpha

Genomic Locations for SCT Gene

Genomic Locations for SCT Gene
2,252 bases
Minus strand
861 bases
Minus strand

Genomic View for SCT Gene

Genes around SCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCT Gene

Proteins for SCT Gene

  • Protein details for SCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for SCT Gene

    121 amino acids
    Molecular mass:
    13016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCT Gene

Post-translational modifications for SCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCT Gene

Domains & Families for SCT Gene

Gene Families for SCT Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SCT Gene

Suggested Antigen Peptide Sequences for SCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucagon family.
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with SCT: view

Function for SCT Gene

Molecular function for SCT Gene

UniProtKB/Swiss-Prot Function:
Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

LifeMap Function Summary for SCT Gene

It affects the following cells:

Phenotypes From GWAS Catalog for SCT Gene

Gene Ontology (GO) - Molecular Function for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 7612008
GO:0005102 signaling receptor binding IBA,IEA --
GO:0005179 hormone activity NAS 11060443
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with SCT: view
genes like me logo Genes that share phenotypes with SCT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCT

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCT

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCT Gene

Localization for SCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCT Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCT gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with SCT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCT Gene

Pathways & Interactions for SCT Gene

genes like me logo Genes that share pathways with SCT: view

Gene Ontology (GO) - Biological Process for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007420 brain development IEA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0030157 pancreatic juice secretion NAS 11060443
GO:0043950 positive regulation of cAMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with SCT: view

No data available for SIGNOR curated interactions for SCT Gene

Drugs & Compounds for SCT Gene

(132) Drugs for SCT Gene - From: ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1231,1231
Pyridoxine Approved, Investigational, Vet_approved Nutra 198,198
Azacitidine Approved, Investigational Pharma 581
Belinostat Approved, Investigational Pharma Histone deacetylase (HDAC)inhibitors 42
Busulfan Approved, Investigational Pharma 569

(49) Additional Compounds for SCT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCT: view

Transcripts for SCT Gene

mRNA/cDNA for SCT Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCT Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCT

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCT Gene

No ASD Table

Relevant External Links for SCT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCT Gene

This gene is overexpressed in Muscle - Skeletal (x8.4), Spleen (x5.1), and Testis (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of SCT Gene:


SOURCE GeneReport for Unigene cluster for SCT Gene:


Evidence on tissue expression from TISSUES for SCT Gene

  • Intestine(3.5)
  • Pancreas(3.2)
  • Blood(2.9)
  • Stomach(2.7)
  • Gall bladder(2.3)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SCT: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCT Gene

Orthologs for SCT Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCT 34 33
  • 98.62 (n)
(Mus musculus)
Mammalia Sct 34
  • 56 (a)
(Bos Taurus)
Mammalia SCT 34
  • 55 (a)
Species where no ortholog for SCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCT Gene

Gene Tree for SCT (if available)
Gene Tree for SCT (if available)
Evolutionary constrained regions (ECRs) for SCT: view image

Paralogs for SCT Gene

No data available for Paralogs for SCT Gene

Variants for SCT Gene

Sequence variations from dbSNP and Humsavar for SCT Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000226608 -- 627,628(-) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000541351 -- 626,871(-) A/C intron_variant
rs1000660706 -- 627,853(-) C/T upstream_transcript_variant
rs1000789412 -- 627,041(-) C/T intron_variant
rs1001696040 -- 627,333(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SCT Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
esv2668299 CNV deletion 23128226
esv2759794 CNV loss 17122850
esv2762889 CNV loss 21179565
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1143528 CNV deletion 24896259
nsv1159791 CNV deletion 26073780
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv552861 CNV loss 21841781
nsv552865 CNV loss 21841781
nsv552866 CNV loss 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for SCT Gene

Gene Damage Index Score: 0.44; 9.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCT Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCT Gene

Disorders for SCT Gene

MalaCards: The human disease database

(38) MalaCards diseases for SCT Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
zollinger-ellison syndrome
  • gastrinoma
  • gastrin cell tumour
exocrine pancreatic insufficiency
  • fatty stool
recurrent acute pancreatitis
  • acute recurrent pancreatitis
- elite association - COSMIC cancer census association via MalaCards
Search SCT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCT

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCT Gene

Publications for SCT Gene

  1. Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. (PMID: 11060443) Whitmore TE … Lok S (Cytogenetics and cell genetics 2000) 3 4 22 58
  2. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 44 58
  3. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. (PMID: 19904746) Onori P … Glaser SS (International journal of cancer 2010) 3 22 58
  4. Peptic ulceration may be a hormonal deficiency disease. (PMID: 18280672) Love JW (Medical hypotheses 2008) 3 22 58
  5. Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1. (PMID: 16888198) Lee LT … Chow BK (Annals of the New York Academy of Sciences 2006) 3 22 58

Products for SCT Gene

Sources for SCT Gene

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