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Aliases for SERPINB3 Gene

Aliases for SERPINB3 Gene

  • Serpin Family B Member 3 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 3 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 2 3
  • Squamous Cell Carcinoma Antigen 1 3 4
  • Protein T4-A 3 4
  • SCCA-1 3 4
  • SCCA1 3 4
  • Serpin B3 3
  • HsT1196 3
  • SCCA-PD 3
  • SSCA1 3
  • T4-A 3
  • SCCA 4
  • SCC 3

External Ids for SERPINB3 Gene

Previous HGNC Symbols for SERPINB3 Gene

  • SCC
  • SCCA1

Previous GeneCards Identifiers for SERPINB3 Gene

  • GC18M061161
  • GC18M061295
  • GC18M059455
  • GC18M059457
  • GC18M059473
  • GC18M058022
  • GC18M061322

Summaries for SERPINB3 Gene

GeneCards Summary for SERPINB3 Gene

SERPINB3 (Serpin Family B Member 3) is a Protein Coding gene. Diseases associated with SERPINB3 include Anus Cancer and Lung Cancer. Among its related pathways are Amoebiasis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB4.

UniProtKB/Swiss-Prot for SERPINB3 Gene

  • May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

Gene Wiki entry for SERPINB3 Gene

Additional gene information for SERPINB3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB3 Gene

Genomics for SERPINB3 Gene

GeneHancer (GH) Regulatory Elements for SERPINB3 Gene

Promoters and enhancers for SERPINB3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J063661 Promoter 0.6 EPDnew 650.7 0.0 -30 0.1 CEBPB SERPINB3 SERPINB11 GC18P063715 GC18P063716
GH18J063662 Promoter 0.6 EPDnew 650.7 +0.1 50 0.1 CEBPB SERPINB3 SERPINB11
GH18J063680 Enhancer 1.2 FANTOM5 Ensembl ENCODE 17.1 -20.7 -20691 3.4 FOXA2 JUN MAX BRCA1 YY1 POLR2A HNF4G RCOR1 FOSL2 MAFK SERPINB3 SERPINB7 SERPINB12 SERPINB11 SERPINB5 GC18P063715 GC18P063716
GH18J063762 Enhancer 0.4 ENCODE dbSUPER 4.4 -100.8 -100814 1.5 SERPINB3 SERPINB7 SERPINB2
GH18J063702 Promoter 0.5 EPDnew 0.3 -41.0 -40978 0.1 SERPINB11 GC18P063715 GC18P063716 SERPINB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB3 gene promoter:
  • HFH-1
  • POU3F2
  • SRF (504 AA)
  • SRF
  • HNF-4alpha2
  • HNF-4alpha1
  • Pax-6
  • Ik-3
  • AREB6
  • Sox9

Genomic Locations for SERPINB3 Gene

Genomic Locations for SERPINB3 Gene
6,767 bases
Minus strand
6,767 bases
Minus strand

Genomic View for SERPINB3 Gene

Genes around SERPINB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB3 Gene

Proteins for SERPINB3 Gene

  • Protein details for SERPINB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin B3
    Protein Accession:
    Secondary Accessions:
    • A6NDM2
    • B2RBT5
    • B3W5Y6
    • Q53H28
    • Q53YB5
    • Q86VF3
    • Q86W04
    • Q8IWL4
    • Q8IXI3
    • Q96J21
    • Q9BYF8

    Protein attributes for SERPINB3 Gene

    390 amino acids
    Molecular mass:
    44565 Da
    Quaternary structure:
    • Interacts with MAPK8/JNK1.
    • Sequence=AAO11731.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINB3 Gene

    Alternative splice isoforms for SERPINB3 Gene


neXtProt entry for SERPINB3 Gene

Post-translational modifications for SERPINB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB3 Gene

Domains & Families for SERPINB3 Gene

Gene Families for SERPINB3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family. Ov-serpin subfamily.
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB3: view

Function for SERPINB3 Gene

Molecular function for SERPINB3 Gene

UniProtKB/Swiss-Prot Function:
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
UniProtKB/Swiss-Prot Induction:
Strongly up-regulated in the upper epidermis of sun-exposed skin.

Gene Ontology (GO) - Molecular Function for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 12975381
GO:0002020 protease binding IPI 21383048
GO:0004867 serine-type endopeptidase inhibitor activity IBA,NAS 7724531
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 21383048
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB3: view
genes like me logo Genes that share phenotypes with SERPINB3: view

Animal Model Products

miRNA for SERPINB3 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINB3 Gene

Localization for SERPINB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB3 Gene

Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB3 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
cytosol 4
plasma membrane 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IDA 20527027
GO:0005737 cytoplasm IEA,IDA 20527027
GO:0031410 cytoplasmic vesicle IDA 21383048
genes like me logo Genes that share ontologies with SERPINB3: view

Pathways & Interactions for SERPINB3 Gene

genes like me logo Genes that share pathways with SERPINB3: view

Pathways by source for SERPINB3 Gene

3 Reactome pathways for SERPINB3 Gene
1 KEGG pathway for SERPINB3 Gene

Gene Ontology (GO) - Biological Process for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 20527027
GO:0010466 negative regulation of peptidase activity IDA,IEA 12949073
GO:0010718 positive regulation of epithelial to mesenchymal transition IMP 20527027
GO:0010950 positive regulation of endopeptidase activity IDA 20527027
GO:0010951 negative regulation of endopeptidase activity IMP 21383048
genes like me logo Genes that share ontologies with SERPINB3: view

No data available for SIGNOR curated interactions for SERPINB3 Gene

Drugs & Compounds for SERPINB3 Gene

(4) Drugs for SERPINB3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-serine Approved, Experimental, Investigational Pharma Agonist, Target 0
phosphoserine Experimental Pharma Target 0

(1) Additional Compounds for SERPINB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB3: view

Transcripts for SERPINB3 Gene


(1) REFSEQ mRNAs :
(23) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB3 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: -
SP2: - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - -
SP9: - - -

Relevant External Links for SERPINB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB3 Gene

This gene is overexpressed in Vagina (x18.3), Esophagus - Mucosa (x17.9), and Cervix - Ectocervix (x12.4).

Protein differential expression in normal tissues from HIPED for SERPINB3 Gene

This gene is overexpressed in Stomach (19.2), Esophagus (11.6), Oral epithelium (8.5), and Urine (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINB3 Gene:


SOURCE GeneReport for Unigene cluster for SERPINB3 Gene:


mRNA Expression by UniProt/SwissProt for SERPINB3 Gene:

Tissue specificity: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).

Evidence on tissue expression from TISSUES for SERPINB3 Gene

  • Lung(4.5)
  • Liver(4.2)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with SERPINB3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB3 Gene

Orthologs for SERPINB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINB3 34 33
  • 97.95 (n)
(Mus musculus)
Mammalia Serpinb3d 16 34 33
  • 71.5 (n)
Serpinb3a 34
  • 60 (a)
Serpinb3b 34
  • 58 (a)
Serpinb3c 34
  • 56 (a)
(Bos Taurus)
Mammalia -- 34
  • 69 (a)
  • 67 (a)
-- 34
  • 66 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
(Canis familiaris)
Mammalia -- 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
-- 34
  • 50 (a)
(Gallus gallus)
Aves OVALY 34
  • 45 (a)
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
-- 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn4 35
  • 36 (a)
Spn1 35
  • 36 (a)
serpin-27A 35
  • 34 (a)
CG9460 35
  • 33 (a)
Spn6 35
  • 33 (a)
Spn3 35
  • 33 (a)
CG9455 35
  • 33 (a)
Spn2 35
  • 32 (a)
Spn43Aa 35
  • 31 (a)
CG6717 35
  • 29 (a)
Spn5 35
  • 28 (a)
nec 35
  • 27 (a)
CG7722 35
  • 27 (a)
CG6687 35
  • 27 (a)
Spn43Ab 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea srp-7 35
  • 31 (a)
srp-1 35
  • 29 (a)
srp-6 35
  • 29 (a)
Species where no ortholog for SERPINB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB3 Gene

Gene Tree for SERPINB3 (if available)
Gene Tree for SERPINB3 (if available)
Evolutionary constrained regions (ECRs) for SERPINB3: view image

Paralogs for SERPINB3 Gene

Variants for SERPINB3 Gene

Sequence variations from dbSNP and Humsavar for SERPINB3 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000864610 -- 63,662,721(-) C/T upstream_transcript_variant
rs1000939413 -- 63,662,470(-) A/G upstream_transcript_variant
rs1001149611 -- 63,658,240(-) G/C intron_variant
rs1001283829 -- 63,655,996(-) T/G coding_sequence_variant, synonymous_variant
rs1001518757 -- 63,658,433(-) G/C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB3 Gene

Variant ID Type Subtype PubMed ID
dgv621e214 CNV loss 21293372
esv2717205 CNV deletion 23290073
esv3642778 CNV loss 21293372
esv3642779 CNV gain 21293372
nsv1057179 CNV loss 25217958
nsv1066552 CNV gain 25217958
nsv833672 CNV gain 17160897

Variation tolerance for SERPINB3 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB3 Gene

Disorders for SERPINB3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SERPINB3 Gene - From: HGMD, LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anus cancer
  • anal cancer
lung cancer
  • lung cancer, susceptibility to
anal carcinoma in situ
  • anal carcinoma stage 0
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
squamous cell carcinoma
  • epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SERPINB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB3 Gene

Publications for SERPINB3 Gene

  1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider SS … Silverman GA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
  2. Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease. (PMID: 18657489) Turato C … Pontisso P (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2009) 3 22 44 58
  3. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. (PMID: 14970861) Pontisso P … Fassina G (British journal of cancer 2004) 3 4 22 58
  4. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PMID: 10956412) Uemura Y … Silverman GA (International journal of cancer 2000) 3 4 22 58
  5. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58

Products for SERPINB3 Gene

Sources for SERPINB3 Gene

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