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Aliases for TSPAN31 Gene

Aliases for TSPAN31 Gene

  • Tetraspanin 31 2 3 5
  • Sarcoma-Amplified Sequence 3 4
  • Tspan-31 3 4
  • SAS 3 4
  • Sarcoma Amplified Sequence 2
  • Transmembrane 4 Protein 3
  • Tetraspanin-31 3

External Ids for TSPAN31 Gene

Previous HGNC Symbols for TSPAN31 Gene

  • SAS

Previous GeneCards Identifiers for TSPAN31 Gene

  • GC12P056426
  • GC12P058138
  • GC12P055175

Summaries for TSPAN31 Gene

Entrez Gene Summary for TSPAN31 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN31 Gene

TSPAN31 (Tetraspanin 31) is a Protein Coding gene. Diseases associated with TSPAN31 include Atypical Lipomatous Tumor and Liposarcoma. An important paralog of this gene is TSPAN13.

Gene Wiki entry for TSPAN31 Gene

Additional gene information for TSPAN31 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN31 Gene

Genomics for TSPAN31 Gene

GeneHancer (GH) Regulatory Elements for TSPAN31 Gene

Promoters and enhancers for TSPAN31 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057733 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 650.7 +0.4 443 9.6 HDGF ARID4B SIN3A ZNF213 E2F8 ZNF143 ZNF548 KLF13 SP3 REST AGAP2 TSPAN31 TSFM NEMP1 ARHGAP9 ATP23 CTDSP2 EEF1AKMT3 ENSG00000224713 CDK4
GH12J057743 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.9 +7.1 7108 2.7 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 TSPAN31 PIR55823 TSFM ATP23 ZBTB39 PRIM1 CYP27B1 METTL1 EEF1AKMT3 CDK4
GH12J057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 33.5 -626.8 -626759 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 CDK4 ANKRD52 DTX3
GH12J057516 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.1 -216.9 -216924 8.8 CLOCK FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MBD6 ENSG00000285133 MIR616 DDIT3 NEMP1 BAZ2A RN7SL809P ZBTB39 EEF1AKMT3 DTX3
GH12J057750 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.2 +15.8 15845 6.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 CDK4 MARCH9 NEMP1 TSFM CTDSP2 EEF1AKMT3 MBD6 ENSG00000224713 RPL13AP23 LINC02403
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN31 gene promoter:
  • AP-1
  • NF-kappaB1
  • NF-kappaB
  • c-Fos
  • c-Jun
  • E2F-3a
  • E2F-2

Genomic Locations for TSPAN31 Gene

Genomic Locations for TSPAN31 Gene
12,199 bases
Plus strand
12,199 bases
Plus strand

Genomic View for TSPAN31 Gene

Genes around TSPAN31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN31 Gene

Proteins for TSPAN31 Gene

  • Protein details for TSPAN31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O00577
    • Q53X76

    Protein attributes for TSPAN31 Gene

    210 amino acids
    Molecular mass:
    23053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN31 Gene

Post-translational modifications for TSPAN31 Gene

  • Glycosylation at posLast=134134, isoforms=117, posLast=109109, and isoforms=100
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSPAN31 Gene

Domains & Families for TSPAN31 Gene

Gene Families for TSPAN31 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TSPAN31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN31: view

Function for TSPAN31 Gene

Phenotypes From GWAS Catalog for TSPAN31 Gene

genes like me logo Genes that share phenotypes with TSPAN31: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN31

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN31 Gene

Localization for TSPAN31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN31 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN31 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8134123
GO:0016020 membrane TAS,IEA 8134123
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN31: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPAN31 Gene

Pathways & Interactions for TSPAN31 Gene

SuperPathways for TSPAN31 Gene

No Data Available

Interacting Proteins for TSPAN31 Gene

Gene Ontology (GO) - Biological Process for TSPAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008284 positive regulation of cell proliferation TAS 8134123
genes like me logo Genes that share ontologies with TSPAN31: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN31 Gene

Drugs & Compounds for TSPAN31 Gene

No Compound Related Data Available

Transcripts for TSPAN31 Gene

mRNA/cDNA for TSPAN31 Gene

Unigene Clusters for TSPAN31 Gene

Tetraspanin 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP8: -

Relevant External Links for TSPAN31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN31 Gene

Protein differential expression in normal tissues from HIPED for TSPAN31 Gene

This gene is overexpressed in Pancreas (30.3), Colon (12.1), and Fetal gut (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN31 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN31 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN31 Gene:


Evidence on tissue expression from TISSUES for TSPAN31 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with TSPAN31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN31 Gene

Orthologs for TSPAN31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN31 34 33
  • 99.84 (n)
(Canis familiaris)
Mammalia TSPAN31 33
  • 94.13 (n)
SAS 34
  • 85 (a)
(Bos Taurus)
Mammalia TSPAN31 34 33
  • 93.81 (n)
(Mus musculus)
Mammalia Tspan31 16 34 33
  • 86.51 (n)
(Rattus norvegicus)
Mammalia Tspan31 33
  • 85.87 (n)
(Anolis carolinensis)
Reptilia TSPAN31 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan31 33
  • 67.15 (n)
Str.10756 33
(Danio rerio)
Actinopterygii sas 34 33
  • 65.87 (n)
zgc56710 33
fruit fly
(Drosophila melanogaster)
Insecta Tsp97E 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10763 34
  • 42 (a)
Species where no ortholog for TSPAN31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN31 Gene

Gene Tree for TSPAN31 (if available)
Gene Tree for TSPAN31 (if available)
Evolutionary constrained regions (ECRs) for TSPAN31: view image

Paralogs for TSPAN31 Gene

Paralogs for TSPAN31 Gene

(2) SIMAP similar genes for TSPAN31 Gene using alignment to 8 proteins:

  • F8VP43_HUMAN
  • F8VS78_HUMAN
  • F8VW54_HUMAN
genes like me logo Genes that share paralogs with TSPAN31: view

Variants for TSPAN31 Gene

Sequence variations from dbSNP and Humsavar for TSPAN31 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1056120320 uncertain-significance, Cutaneous Malignant Melanoma, Dominant 57,747,836(+) G/A/C 3_prime_UTR_variant
rs112275916 benign, Cutaneous Malignant Melanoma, Dominant 57,748,034(+) G/A/T 3_prime_UTR_variant
rs113625101 likely-benign, Cutaneous Malignant Melanoma, Dominant 57,748,004(+) C/T 3_prime_UTR_variant
rs115576923 likely-benign, Hereditary cutaneous melanoma, not specified, Hereditary cancer-predisposing syndrome 57,748,603(+) A/G downstream_transcript_variant
rs146863045 uncertain-significance, Cutaneous Malignant Melanoma, Dominant 57,747,748(+) TTTTTTTTTTTTT/TTTTTTTTTT/TTTTTTTTTTTT/TTTTTTTTTTTTTT 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN31 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv819021 CNV loss 19587683
nsv826384 CNV gain 20364138
nsv826386 CNV gain 20364138

Variation tolerance for TSPAN31 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN31 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN31 Gene

Disorders for TSPAN31 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TSPAN31 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
atypical lipomatous tumor
  • atypical lipoma
  • cutaneous fibrous histiocytoma
well-differentiated liposarcoma
  • pleomorphic lipoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPAN31

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TSPAN31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN31 Gene

Publications for TSPAN31 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (PMID: 15024701) Ragazzini P … Benassi MS (Histology and histopathology 2004) 3 22 58
  5. Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. (PMID: 9192850) Elkahloun AG … Meltzer PS (Genomics 1997) 3 4 58

Products for TSPAN31 Gene

Sources for TSPAN31 Gene

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