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Aliases for S100A6 Gene

Aliases for S100A6 Gene

  • S100 Calcium Binding Protein A6 2 3 5
  • Calcyclin 2 3 4
  • Prolactin Receptor-Associated Protein 3 4
  • Growth Factor-Inducible Protein 2A9 3 4
  • MLN 4 3 4
  • CACY 3 4
  • PRA 3 4
  • S100 Calcium-Binding Protein A6 (Calcyclin) 2
  • S100 Calcium-Binding Protein A6 4
  • Protein S100-A6 3
  • S10A6 3
  • 5B10 3
  • CABP 3
  • 2A9 3

External Ids for S100A6 Gene

Previous HGNC Symbols for S100A6 Gene

  • CACY

Previous GeneCards Identifiers for S100A6 Gene

  • GC01M151323
  • GC01M149289
  • GC01M150334
  • GC01M150775
  • GC01M150320
  • GC01M151774
  • GC01M124870

Summaries for S100A6 Gene

Entrez Gene Summary for S100A6 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A6 Gene

S100A6 (S100 Calcium Binding Protein A6) is a Protein Coding gene. Diseases associated with S100A6 include Endometrial Cancer and Uterine Corpus Cancer. Among its related pathways are Ca, cAMP and Lipid Signaling and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100A5.

UniProtKB/Swiss-Prot for S100A6 Gene

  • May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.

Gene Wiki entry for S100A6 Gene

Additional gene information for S100A6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A6 Gene

Genomics for S100A6 Gene

GeneHancer (GH) Regulatory Elements for S100A6 Gene

Promoters and enhancers for S100A6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153531 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +1.1 1114 8.2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A ZNF143 FOS DEK SP5 ENSG00000238279 PIR41635 S100A6 S100A7 S100A3 INTS3 CHTOP UBAP2L ENSG00000272654 RN7SL44P
GH01J153561 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.9 -29.3 -29317 8.8 DMAP1 YY1 ZNF213 ZNF143 SP3 MEF2D GLIS1 NBN KDM1A WT1 S100A3 S100A2 S100A6 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1
GH01J153494 Enhancer 0.8 ENCODE 11.6 +41.2 41174 0.2 HDGF PKNOX1 RB1 INSM2 KLF17 KLF14 ZNF2 KLF5 RAD21 ARID2 CRTC2 SLC27A3 SLC39A1 ENSG00000238279 S100A6 S100A5 S100A3 S100A4 UBAP2L PGLYRP4
GH01J153606 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.9 -76.2 -76215 11.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B S100A16 S100A14 S100A1 SNAPIN ILF2 ENSG00000233222 ENSG00000243613 INTS3 S100A13 ENSG00000272030
GH01J153492 Enhancer 0.4 dbSUPER 11.6 +42.6 42623 2.1 CTCF RFX1 NR2F2 RN7SL44P ENSG00000238279 S100A6 S100A5 S100A3 S100A4 PGLYRP4 S100A9 RNU6-160P S100A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100A6 gene promoter:
  • c-Jun
  • ATF-2
  • AML1a

Genomic Locations for S100A6 Gene

Genomic Locations for S100A6 Gene
chr1:153,534,599-153,536,244
(GRCh38/hg38)
Size:
1,646 bases
Orientation:
Minus strand
chr1:153,507,075-153,508,720
(GRCh37/hg19)
Size:
1,646 bases
Orientation:
Minus strand

Genomic View for S100A6 Gene

Genes around S100A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A6 Gene

Proteins for S100A6 Gene

  • Protein details for S100A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06703-S10A6_HUMAN
    Recommended name:
    Protein S100-A6
    Protein Accession:
    P06703
    Secondary Accessions:
    • D3DV39
    • Q5RHS4

    Protein attributes for S100A6 Gene

    Size:
    90 amino acids
    Molecular mass:
    10180 Da
    Quaternary structure:
    • Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    Miscellaneous:
    • This protein co-purified with the prolactin receptor.

    Three dimensional structures from OCA and Proteopedia for S100A6 Gene

neXtProt entry for S100A6 Gene

Post-translational modifications for S100A6 Gene

Other Protein References for S100A6 Gene

No data available for DME Specific Peptides for S100A6 Gene

Domains & Families for S100A6 Gene

Gene Families for S100A6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for S100A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06703

UniProtKB/Swiss-Prot:

S10A6_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A6: view

Function for S100A6 Gene

Molecular function for S100A6 Gene

UniProtKB/Swiss-Prot Function:
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
UniProtKB/Swiss-Prot Induction:
Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.
GENATLAS Biochemistry:
S100 calcium binding protein A6,10.2kDa,epidermal differentiation complex

Phenotypes From GWAS Catalog for S100A6 Gene

Gene Ontology (GO) - Molecular Function for S100A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS,IEA 12577318
GO:0005515 protein binding IPI 10913138
GO:0005523 tropomyosin binding IDA 19724273
GO:0008270 zinc ion binding IEA --
GO:0015075 ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with S100A6: view
genes like me logo Genes that share phenotypes with S100A6: view

Animal Models for S100A6 Gene

MGI Knock Outs for S100A6:
  • S100a6 S100a6<tm1b(KOMP)Wtsi>

Animal Model Products

miRNA for S100A6 Gene

miRTarBase miRNAs that target S100A6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A6 Gene

Localization for S100A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A6 Gene

Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 10913138
GO:0005576 extracellular region IDA 27068509
GO:0005634 nucleus IEA,IDA 10913138
GO:0005635 nuclear envelope NAS 12577318
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with S100A6: view

Pathways & Interactions for S100A6 Gene

genes like me logo Genes that share pathways with S100A6: view

Pathways by source for S100A6 Gene

2 Cell Signaling Technology pathways for S100A6 Gene

Gene Ontology (GO) - Biological Process for S100A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 16130169
GO:0007409 axonogenesis NAS 12152788
GO:0034220 ion transmembrane transport IEA --
GO:0048146 positive regulation of fibroblast proliferation NAS 12577318
genes like me logo Genes that share ontologies with S100A6: view

No data available for SIGNOR curated interactions for S100A6 Gene

Drugs & Compounds for S100A6 Gene

(17) Drugs for S100A6 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Citrate Approved Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0

(13) Additional Compounds for S100A6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A6: view

Transcripts for S100A6 Gene

mRNA/cDNA for S100A6 Gene

Unigene Clusters for S100A6 Gene

S100 calcium binding protein A6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: -

Relevant External Links for S100A6 Gene

GeneLoc Exon Structure for
S100A6
ECgene alternative splicing isoforms for
S100A6

Expression for S100A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A6 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for S100A6 Gene

This gene is overexpressed in Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100A6 Gene



Protein tissue co-expression partners for S100A6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A6 Gene:

S100A6

SOURCE GeneReport for Unigene cluster for S100A6 Gene:

Hs.275243

Evidence on tissue expression from TISSUES for S100A6 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Blood(4.4)
  • Lung(4.3)
  • Intestine(4.2)
  • Pancreas(4.1)
  • Stomach(4.1)
  • Skin(3.6)
  • Muscle(3.2)
  • Kidney(3.1)
  • Heart(3)
  • Thyroid gland(2.6)
  • Bone marrow(2.5)
  • Gall bladder(2.5)
  • Lymph node(2.5)
  • Spleen(2.4)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with S100A6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A6 Gene

Orthologs for S100A6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A6 34 33
  • 99.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia S100a6 16 34 33
  • 93.26 (n)
dog
(Canis familiaris)
Mammalia S100A6 34 33
  • 92.59 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a6 33
  • 92.51 (n)
cow
(Bos Taurus)
Mammalia S100A6 33
  • 86.05 (n)
oppossum
(Monodelphis domestica)
Mammalia S100A6 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S100A6 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves S100A6 33
  • 84.85 (n)
Species where no ortholog for S100A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A6 Gene

ENSEMBL:
Gene Tree for S100A6 (if available)
TreeFam:
Gene Tree for S100A6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100A6: view image

Paralogs for S100A6 Gene

Paralogs for S100A6 Gene

(20) SIMAP similar genes for S100A6 Gene using alignment to 2 proteins:

  • S10A6_HUMAN
  • R4GN98_HUMAN
genes like me logo Genes that share paralogs with S100A6: view

Variants for S100A6 Gene

Sequence variations from dbSNP and Humsavar for S100A6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000035379 -- 153,534,199(-) T/C downstream_transcript_variant
rs1001569357 -- 153,535,022(-) C/T intron_variant
rs1002887494 -- 153,535,961(-) G/A 5_prime_UTR_variant
rs1003199194 -- 153,537,725(-) A/C upstream_transcript_variant
rs1003265446 -- 153,536,191(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for S100A6 Gene

Variant ID Type Subtype PubMed ID
esv3587584 CNV gain 21293372
esv3587591 CNV gain 21293372
nsv1002705 CNV gain 25217958
nsv831603 CNV gain 17160897

Variation tolerance for S100A6 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A6 Gene

Disorders for S100A6 Gene

MalaCards: The human disease database

(11) MalaCards diseases for S100A6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
uterine corpus cancer
  • corpus uteri cancer
epidermoid cysts
  • epidermoid cyst
cutaneous ganglioneuroma
  • ganglioneuroma of skin
capillariasis
  • capillaria infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with S100A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A6 Gene

Publications for S100A6 Gene

  1. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (PMID: 19724273) Nedjadi T … Costello E (British journal of cancer 2009) 3 4 22 58
  2. Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. (PMID: 12601007) Tomas A … Moss SE (The Journal of biological chemistry 2003) 3 4 22 58
  3. Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. (PMID: 11937060) Otterbein LR … Dominguez R (Structure (London, England : 1993) 2002) 3 4 22 58
  4. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PMID: 20188096) Shimamoto S … Kobayashi R (FEBS letters 2010) 3 4 58
  5. Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer. (PMID: 18620780) De Petris L … Lehtiö J (Lung cancer (Amsterdam, Netherlands) 2009) 3 22 58

Products for S100A6 Gene

Sources for S100A6 Gene

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