Aliases for S100A5 Gene
External Ids for S100A5 Gene
Previous HGNC Symbols for S100A5 Gene
Previous GeneCards Identifiers for S100A5 Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]
GeneCards Summary for S100A5 Gene
S100A5 (S100 Calcium Binding Protein A5) is a Protein Coding gene. Diseases associated with S100A5 include Meningioma, Familial and Epidermoid Cysts. Gene Ontology (GO) annotations related to this gene include calcium ion binding and copper ion binding. An important paralog of this gene is S100A2.
UniProtKB/Swiss-Prot for S100A5 Gene
Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.