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Aliases for S100A2 Gene

Aliases for S100A2 Gene

  • S100 Calcium Binding Protein A2 2 3 5
  • S100 Calcium-Binding Protein A2 2 4
  • S100L 3 4
  • CAN19 3 4
  • Protein S100-A2 3
  • Protein S-100L 4

External Ids for S100A2 Gene

Previous HGNC Symbols for S100A2 Gene

  • S100L

Previous GeneCards Identifiers for S100A2 Gene

  • GC01M151349
  • GC01M149316
  • GC01M150360
  • GC01M150802
  • GC01M150346
  • GC01M151800
  • GC01M124896

Summaries for S100A2 Gene

Entrez Gene Summary for S100A2 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A2 Gene

S100A2 (S100 Calcium Binding Protein A2) is a Protein Coding gene. Diseases associated with S100A2 include Epidermoid Cysts and Chondromyxoid Fibroma. Among its related pathways are Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A4.

UniProtKB/Swiss-Prot for S100A2 Gene

  • May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.

Gene Wiki entry for S100A2 Gene

Additional gene information for S100A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A2 Gene

Genomics for S100A2 Gene

GeneHancer (GH) Regulatory Elements for S100A2 Gene

Promoters and enhancers for S100A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153561 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.9 +2.3 2329 8.8 DMAP1 YY1 ZNF213 ZNF143 SP3 MEF2D GLIS1 NBN KDM1A WT1 S100A3 S100A2 S100A6 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1
GH01J153606 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.8 -44.6 -44569 11.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B S100A16 S100A14 S100A1 SNAPIN ILF2 ENSG00000233222 ENSG00000243613 INTS3 S100A13 ENSG00000272030
GH01J153514 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +52.1 52103 2.4 KLF1 MAX CEBPG POLR2A SMC3 ZNF444 DEK SMARCC1 SP3 MAZ S100A3 RN7SL44P S100A2 S100A14 PGLYRP4 S100A6 S100A16 GC01M153500 ENSG00000238279
GH01J153572 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -4.8 -4849 2.2 ELF3 RB1 ARID4B SIN3A RAD21 RFX5 ZNF335 EGR1 ZNF143 RCOR1 INTS3 ATP8B2 UBAP2L S100A3 S100A9 S100A7L2 S100A12 S100A4 S100A2 PIR44602
GH01J153552 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +14.0 14022 1.8 ZFHX2 EGR2 S100A3 CHTOP S100A13 S100A16 S100A14 S100A1 INTS3 ENSG00000233222 ENSG00000243613 ILF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100A2 gene promoter:
  • p53
  • Nkx2-5
  • Egr-2
  • FOXJ2 (long isoform)
  • FOXJ2

Genomic Locations for S100A2 Gene

Genomic Locations for S100A2 Gene
6,783 bases
Minus strand
6,783 bases
Minus strand

Genomic View for S100A2 Gene

Genes around S100A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A2 Gene

Proteins for S100A2 Gene

  • Protein details for S100A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A2
    Protein Accession:
    Secondary Accessions:
    • O00266
    • Q3KRB9
    • Q5RHS8
    • Q9BU83

    Protein attributes for S100A2 Gene

    98 amino acids
    Molecular mass:
    11117 Da
    Quaternary structure:
    • Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    • This protein binds two calcium ions.
    • Sequence=CAA69033.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for S100A2 Gene

neXtProt entry for S100A2 Gene

Post-translational modifications for S100A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A2 Gene

Antibody Products

No data available for DME Specific Peptides for S100A2 Gene

Domains & Families for S100A2 Gene

Gene Families for S100A2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for S100A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A2: view

Function for S100A2 Gene

Molecular function for S100A2 Gene

UniProtKB/Swiss-Prot Function:
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.
UniProtKB/Swiss-Prot Induction:
By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells.
GENATLAS Biochemistry:
S100 calcium binding protein A2,epidermal diffentiation complex

Gene Ontology (GO) - Molecular Function for S100A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 9481475
GO:0005515 protein binding IPI 20188096
GO:0042802 identical protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
GO:0046914 transition metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A2: view
genes like me logo Genes that share phenotypes with S100A2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A2 Gene

Localization for S100A2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A2 gene
Compartment Confidence
cytosol 4
extracellular 3
nucleus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with S100A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for S100A2 Gene

Pathways & Interactions for S100A2 Gene

SuperPathways for S100A2 Gene

SuperPathway Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with S100A2: view

Pathways by source for S100A2 Gene

1 BioSystems pathway for S100A2 Gene

Gene Ontology (GO) - Biological Process for S100A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043542 endothelial cell migration IMP 15313892
genes like me logo Genes that share ontologies with S100A2: view

No data available for SIGNOR curated interactions for S100A2 Gene

Drugs & Compounds for S100A2 Gene

(8) Drugs for S100A2 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra Target 0
Olopatadine Approved Pharma Target, antagonist 0
Zinc Approved, Investigational Pharma Target 2430
Copper Approved, Investigational Pharma Target 202
Patanase Approved April 2008 Pharma 0

(3) Additional Compounds for S100A2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A2: view

Transcripts for S100A2 Gene

mRNA/cDNA for S100A2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(133) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A2 Gene

S100 calcium binding protein A2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP2: -
SP3: -
SP4: - -

Relevant External Links for S100A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A2 Gene

This gene is overexpressed in Esophagus - Mucosa (x27.8), Minor Salivary Gland (x6.4), Vagina (x4.8), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for S100A2 Gene

This gene is overexpressed in Hair follicle (36.0) and Cervix (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of S100A2 Gene:


SOURCE GeneReport for Unigene cluster for S100A2 Gene:


mRNA Expression by UniProt/SwissProt for S100A2 Gene:

Tissue specificity: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes.

Evidence on tissue expression from TISSUES for S100A2 Gene

  • Skin(4.6)
  • Lung(3.7)
genes like me logo Genes that share expression patterns with S100A2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A2 Gene

Orthologs for S100A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A2 34 33
  • 98.63 (n)
(Bos Taurus)
Mammalia S100A2 34 33
  • 90.97 (n)
(Canis familiaris)
Mammalia S100A2 34 33
  • 87.97 (n)
(Ornithorhynchus anatinus)
Mammalia S100A2 34
  • 77 (a)
Species where no ortholog for S100A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A2 Gene

Gene Tree for S100A2 (if available)
Gene Tree for S100A2 (if available)
Evolutionary constrained regions (ECRs) for S100A2: view image

Paralogs for S100A2 Gene

Paralogs for S100A2 Gene

(19) SIMAP similar genes for S100A2 Gene using alignment to 3 proteins:

  • S10A2_HUMAN
  • R4GN49_HUMAN
genes like me logo Genes that share paralogs with S100A2: view

Variants for S100A2 Gene

Sequence variations from dbSNP and Humsavar for S100A2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000130986 -- 153,566,358(-) A/T upstream_transcript_variant
rs1000267225 -- 153,566,132(-) G/C upstream_transcript_variant
rs1000455946 -- 153,562,071(-) C/T intron_variant
rs1000464467 -- 153,564,772(-) T/C intron_variant
rs1000601230 -- 153,564,361(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for S100A2 Gene

Variant ID Type Subtype PubMed ID
esv3587584 CNV gain 21293372
esv3587591 CNV gain 21293372
nsv831603 CNV gain 17160897

Variation tolerance for S100A2 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A2 Gene

Disorders for S100A2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for S100A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epidermoid cysts
  • epidermoid cyst
chondromyxoid fibroma
  • fibroma chondromyxoid
lung cancer
  • lung cancer, susceptibility to
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with S100A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A2 Gene

Publications for S100A2 Gene

  1. Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer. (PMID: 18656279) Strazisar M … Glavac D (Lung cancer (Amsterdam, Netherlands) 2009) 3 22 44 58
  2. S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis. (PMID: 11260185) Stoll SW … Elder JT (Clinical and experimental dermatology 2001) 3 22 44 58
  3. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. (PMID: 9481475) Wicki R … Schäfer BW (Cell calcium 1997) 3 4 22 58
  4. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PMID: 20188096) Shimamoto S … Kobayashi R (FEBS letters 2010) 3 4 58
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58

Products for S100A2 Gene

Sources for S100A2 Gene

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