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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate ... See more...
Aliases for RPS6KA1 Gene
Aliases for RPS6KA1 Gene
- Ribosomal Protein S6 Kinase A1 2 3 5
- RSK1 2 3 4
- MAP Kinase-Activated Protein Kinase 1a 3 4
- 90 KDa Ribosomal Protein S6 Kinase 1 3 4
- Ribosomal Protein S6 Kinase Alpha-1 3 4
- MAPK-Activated Protein Kinase 1a 3 4
- Ribosomal S6 Kinase 1 3 4
- MAPKAP Kinase 1a 3 4
- EC 2.7.11.1 4 51
- MAPKAPK-1a 3 4
- MAPKAPK1A 3 4
- P90-RSK 1 3 4
- MAPKAPK1 2 3
External Ids for RPS6KA1 Gene
- HGNC: 10430
- Entrez Gene: 6195
- Ensembl: ENSG00000117676
- OMIM: 601684
- UniProtKB: Q15418
Previous GeneCards Identifiers for RPS6KA1 Gene
- GC01P028654
- GC01P025888
- GC01P026089
- GC01P026460
- GC01P026728
- GC01P026856
- GC01P025110
Summaries for RPS6KA1 Gene
-
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPS6KA1 Gene
RPS6KA1 (Ribosomal Protein S6 Kinase A1) is a Protein Coding gene. Diseases associated with RPS6KA1 include Coffin-Lowry Syndrome and Tuberous Sclerosis. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and NGF Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.
UniProtKB/Swiss-Prot Summary for RPS6KA1 Gene
-
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).
-
Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.
Additional gene information for RPS6KA1 Gene
- HGNC(10430)
- Entrez Gene(6195)
- Ensembl(ENSG00000117676)
- OMIM(601684)
- UniProtKB(Q15418)
- Open Targets Platform(ENSG00000117676)
- Search for RPS6KA1 at DataMed
- Search for RPS6KA1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS6KA1 Gene
Genomics for RPS6KA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RPS6KA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RPS6KA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS6KA1
- Top Transcription factor binding sites by QIAGEN in the RPS6KA1 gene promoter:
-
- C/EBPbeta
- Elk-1
- HNF-4alpha1
- NF-kappaB
- NF-kappaB1
Genomic Locations for RPS6KA1 Gene
Genomic Locations for RPS6KA1 Gene
- chr1:26,529,761-26,575,030
- (GRCh38/hg38)
- Size:
- 45,270 bases
- Orientation:
- Plus strand
- chr1:26,856,249-26,901,521
- (GRCh37/hg19)
- Size:
- 45,273 bases
- Orientation:
- Plus strand
Genomic View for RPS6KA1 Gene
Genes around RPS6KA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by HGNC
- 1p36.11 by Entrez Gene
- 1p36.11 by Ensembl
RPS6KA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPS6KA1 Gene
Proteins for RPS6KA1 Gene
-
Protein details for RPS6KA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15418-KS6A1_HUMAN
- Recommended name:
- Ribosomal protein S6 kinase alpha-1
- Protein Accession:
- Q15418
- A6NGG4
- A8K9K7
- B2RDY8
- B7Z5J0
- E9PRI4
- Q5SVM5
- Q5SVM8
- Q5SVM9
- Q96C05
- Q9BQK2
Protein attributes for RPS6KA1 Gene
- Size:
- 735 amino acids
- Molecular mass:
- 82723 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1.
Three dimensional structures from OCA and Proteopedia for RPS6KA1 Gene
Protein Expression for RPS6KA1 Gene
Selected DME Specific Peptides for RPS6KA1 Gene
- Q15418:
-
- DVKFYLAEL
- ELMRGGELLD
- GIIYRDLK
- DKILRQK
- FTRLSKEV
- LVKGAMAATYSALN
- VSKMLHVDPHQRLTA
- EAQSLLRALFKRNPANRLGSGPDGAEEIKRH
- LDHLHSLGIIYRDLKPENILLDEEGHIK
- PFVVKLH
- YSFCGTVEYMAPEV
- LYAMKVL
- LHYAFQT
- TNMEYAVKVIDK
- QGVVHRDLKPSNILY
- HKATNME
- PLHSVVQQLHGKN
- RLTAKQVL
- GHIKLTDFGLSK
- ILKAKLGMPQFLS
- HRDLKPSNIL
- FYSTIDWNKLYRREIKPPFKPAV
- IKLTDFG
- AVKVIDK
- IGVGSYS
- LKVRDRVRTKMERDIL
- GVLMFEMLTG
- EYAVKVID
- VVHRDLK
- LTDFGLSK
- CDIWSLG
- KLTDFGL
- KRDPSEEIEIL
- TPFANGP
- IDKSKRDP
- FRGFSFV
- EYMAPEVV
- LGIIYRD
- RDLKPEN
- GHIKLTD
- RYGQHPNII
- GKVFLVRK
- FELLKVLG
- TPCYTANFVAPEVL
- QVLQHPW
- LPFQGKDR
- SSILAQRRV
- VHRDLKP
- ILRQKFFSEREA
- KPENILLD
Post-translational modifications for RPS6KA1 Gene
- Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.
- N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
-
Ubiquitination at Lys66, Lys278, and Lys316
- NX_Q15418 (NX_Q15418-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RPS6KA1 Gene
Antibody Products
- LifeSpan BioSciences RPS6KA1 / RSK1 Antibody
- NSJ Bioreagents RSK1 / RPS6KA1 Antibody (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for RPS6KA1
- AM06174SU-N
- AP02397PU-N
- AP02397PU-S
- AP02663PU-N
- AP02663PU-S
- AP02664PU-N
- AP02664PU-S
- AP06435PU-N
- AP06436PU-N
- AP07347PU-N
- AP07471PU-N
- AP08006PU-N
- AP08006PU-S
- AP09419PU-N
- AP09419PU-S
- AP12877PU-N
- AP20323PU-N
- AP53743PU-N
- TA302100
- TA306221
- TA308953
- TA323474
- TA323475
- TA323476
- TA326079
- TA326159
- TA326168
- TA326338
- TA350373
- Novus Biologicals Antibodies for RPS6KA1
-
Abcam antibodies for RPS6KA1
- Invitrogen Antibodies for RPS6KA1 (AFLGC-Rps6ka1)
- antibodies-online: Show 151 available RPS6KA1 Antibodies ranked by validation data
- Compare Top RPS6KA1 Antibodies
-
Recommended
- 317 WB Antibodies (anti-human)
- 46 IF (p) Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 174 WB Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 143 WB Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for RPS6KA1
-
Custom Antibody ServicesProSci Antibodies for RPS6KA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RPS6KA1
- Sino Biological Antibodies for RPS6KA1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RPS6KA1
- Origene Custom Protein Services for RPS6KA1
-
Signalway Proteins for RPS6KA1
-
ProSci Proteins for RPS6KA1
-
Abcam proteins for RPS6KA1
Assay Products
-
Signalway ELISA kits for RPS6KA1
Domains & Families for RPS6KA1 Gene
Gene Families for RPS6KA1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RPS6KA1 Gene
- InterPro:
- Blocks:
-
- Protein kinase C-terminal domain
- ProtoNet:
Suggested Antigen Peptide Sequences for RPS6KA1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ribosomal S6 kinase 1 (KS6A1_HUMAN)
- Ribosomal protein S6 kinase, 90kDa, polypeptide 1 (Q5SVM6_HUMAN)
- Ribosomal protein S6 kinase, 90kDa, polypeptide 1 (Q5SVM7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15418UniProtKB/Swiss-Prot:
KS6A1_HUMAN :- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Function for RPS6KA1 Gene
Molecular function for RPS6KA1 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
- GENATLAS Biochemistry:
- ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
Enzyme Numbers (IUBMB) for RPS6KA1 Gene
Phenotypes From GWAS Catalog for RPS6KA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,IDA | 10679322 |
| GO:0004711 | ribosomal protein S6 kinase activity | IBA | 21873635 |
Phenotypes for RPS6KA1 Gene
- MGI mutant phenotypes for RPS6KA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RPS6KA1:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased cell death HMECs cells
- Resistant to vaccinia virus (VACV-A4L) infection
- shRNA abundance <= 50%
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased cell migration
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased cell viability after pRB stimulation
- Decreased substrate adherent cell growth
- Increased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell migration
- Synthetic lethal with cisplatin
Animal Model Products
-
Taconic Biosciences Mouse Models for RPS6KA1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RPS6KA1 - Select products 50% OFF >
- * RPS6KA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RPS6KA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPS6KA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS6KA1
miRNA for RPS6KA1 Gene
- miRTarBase miRNAs that target RPS6KA1
-
- hsa-miR-125b-5p (MIRT006430)
- hsa-miR-193b-3p (MIRT041478)
- hsa-miR-769-3p (MIRT722101)
- hsa-miR-450b-3p (MIRT722102)
- hsa-miR-4769-5p (MIRT722103)
- hsa-miR-4654 (MIRT722104)
- hsa-miR-6766-5p (MIRT722105)
- hsa-miR-6756-5p (MIRT722106)
- hsa-miR-638 (MIRT722107)
- hsa-miR-4713-3p (MIRT722108)
- hsa-miR-6502-5p (MIRT722109)
- hsa-miR-1301-5p (MIRT722110)
- hsa-miR-520f-5p (MIRT722111)
- hsa-miR-4509 (MIRT722112)
- hsa-miR-4744 (MIRT722113)
- hsa-miR-186-3p (MIRT722114)
- hsa-miR-4733-5p (MIRT722115)
- hsa-miR-4429 (MIRT722116)
- hsa-miR-320d (MIRT722117)
- hsa-miR-320c (MIRT722118)
- hsa-miR-320b (MIRT722119)
- hsa-miR-320a (MIRT722120)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPS6KA1
- Browse OriGene Inhibitory RNA Products For RPS6KA1
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Clone Products
- Applied Biological Materials (abm): Clones for RPS6KA1 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210359
- MG227425
- MR210359
- MR210359L3
- MR210359L4
- MR227425
- MR227425L3
- MR227425L4
- MR230973
- MR230989
- RC204874
- RC204874L1
- RC204874L2
- RC204874L3
- RC204874L4
- RC219895
- RC219895L3
- RC219895L4
- RG204874
- RG219895
- RR211767
- RR211767L3
- RR211767L4
- MR210359L3V
- MR210359L4V
- MR227425L3V
- MR227425L4V
- RC204874L1V
- RC204874L2V
- RC204874L3V
- RC204874L4V
- RC219895L3V
- RC219895L4V
- RR211767L3V
- RR211767L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RPS6KA1
- Addgene plasmids for RPS6KA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPS6KA1
Cell Line Products
-
Horizon Cell Lines for RPS6KA1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6KA1 Gene
Localization for RPS6KA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
Pathways & Interactions for RPS6KA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Post NMDA receptor activation events |
.01
|
|
| 3 | Nuclear Events (kinase and transcription factor activation) |
.88
|
|
| 4 | GDNF-Family Ligands and Receptor Interactions |
GDNF-Family Ligands and Receptor Interactions
.41
Development GDNF family signaling
.41
|
BDNF Pathway
.39
|
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
|
ERK5 Signaling
.61
|
Pathways by source for RPS6KA1 Gene
4 Sino Biological pathways for RPS6KA1 Gene
16 BioSystems pathways for RPS6KA1 Gene
43 Reactome pathways for RPS6KA1 Gene
9 KEGG pathways for RPS6KA1 Gene
14 GeneGo (Thomson Reuters) pathways for RPS6KA1 Gene
- Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
- Apoptosis and survival BAD phosphorylation
- Development A2A receptor signaling
- Development ACM2 and ACM4 activation of ERK
- Development Flt3 signaling
5 Tocris pathways for RPS6KA1 Gene
23 Qiagen pathways for RPS6KA1 Gene
- 14-3-3 Induced Apoptosis
- 14-3-3 Induced Intracellular Signaling
- Activation of PKC through GPCR
- BAD Phosphorylation
- BDNF Pathway
1 Cell Signaling Technology pathway for RPS6KA1 Gene
Interacting Proteins for RPS6KA1 Gene
Selected Interacting proteins:
Q15418-KS6A1_HUMAN
ENSP00000435412
for RPS6KA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RPS6KA1
SIGNOR curated interactions for RPS6KA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8141249 |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for RPS6KA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| Purvalanol A | Experimental | Pharma | Target | 0 | ||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| BRD 7389 | Pharma | P90 RSK inhibitor, Ribosomal S6 kinase inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
| RMM 46 |
|
1307896-46-3 |
|
|
(4) Tocris Compounds for RPS6KA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BRD 7389 | Ribosomal S6 kinase inhibitor | 376382-11-5 |
| PF 4708671 | S6K1 inhibitor | 1255517-76-0 |
| RMM 46 | MSK/RSK family kinase inhibitor | 1307896-46-3 |
| SL 0101-1 | Selective ribosomal S6 kinase (RSK) inhibitor | 77307-50-7 |
(4) ApexBio Compounds for RPS6KA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BI-D1870 | P90 RSK inhibitor,ATP-competitive and cell-permeable | 501437-28-1 |
| BRD 7389 | P90 RSK inhibitor | 376382-11-5 |
| PF-4708671 | P70 S6K1 isoform inhibitor,cell-permeable | 1255517-76-0 |
| SL 0101-1 | 77307-50-7 |
Transcripts for RPS6KA1 Gene
mRNA/cDNA for RPS6KA1 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000366866 592 nts (view in UCSC)
- ENST00000374163 3202 nts (view in UCSC)
- ENST00000374166 3131 nts (view in UCSC)
- ENST00000374168 3192 nts (view in UCSC)
- ENST00000403732 498 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RPS6KA1 - Select products 50% OFF >
- * RPS6KA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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OriGene CRISPR knockouts for RPS6KA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPS6KA1
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Santa Cruz Biotechnology (SCBT) CRISPR for RPS6KA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPS6KA1
- Browse OriGene Inhibitory RNA Products For RPS6KA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6KA1
Clone Products
- Applied Biological Materials (abm): Clones for RPS6KA1 - Select products 50% OFF >
- * RPS6KA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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- MG210359
- MG227425
- MR210359
- MR210359L3
- MR210359L4
- MR227425
- MR227425L3
- MR227425L4
- MR230973
- MR230989
- RC204874
- RC204874L1
- RC204874L2
- RC204874L3
- RC204874L4
- RC219895
- RC219895L3
- RC219895L4
- RG204874
- RG219895
- RR211767
- RR211767L3
- RR211767L4
- MR210359L3V
- MR210359L4V
- MR227425L3V
- MR227425L4V
- RC204874L1V
- RC204874L2V
- RC204874L3V
- RC204874L4V
- RC219895L3V
- RC219895L4V
- RR211767L3V
- RR211767L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RPS6KA1
- Addgene plasmids for RPS6KA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPS6KA1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: |
Relevant External Links for RPS6KA1 Gene
- GeneLoc Exon Structure for
- RPS6KA1
Expression for RPS6KA1 Gene
mRNA differential expression in normal tissues according to GTEx for RPS6KA1 Gene
This gene is overexpressed in Whole Blood (x21.5).
This gene is overexpressed in Lymph node (11.8), Stomach (7.0), Peripheral blood mononuclear cells (7.0), and Salivary gland (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KA1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS6KA1
SOURCE GeneReport for Unigene cluster for RPS6KA1 Gene:
Hs.149957Evidence on tissue expression from TISSUES for RPS6KA1 Gene
- Intestine(4.7)
- Liver(4.5)
- Thyroid gland(4.5)
- Blood(3.1)
- Nervous system(3)
- Lung(3)
- Kidney(2.9)
- Skin(2.8)
- Adrenal gland(2.7)
- Heart(2.7)
- Lymph node(2.7)
- Spleen(2.6)
- Muscle(2.6)
- Bone marrow(2.6)
- Pancreas(2.5)
- Stomach(2.5)
- Eye(2)
Primer Products
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OriGene qPCR primer pairs for RPS6KA1
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OriGene qPCR primer pairs and template standards for RPS6KA1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KA1 Gene
Orthologs for RPS6KA1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RPS6KA1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RPS6KA1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RPS6KA1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rps6ka1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rps6ka1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RPS6KA1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RPS6KA1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RPS6KA 31 |
|
OneToOne | |
| RPS6KA1 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rps6ka1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.856 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rps6ka1 31 |
|
OneToOne | |
| rps6ka3a 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | S6kII 31 |