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Aliases for RPS5 Gene

Aliases for RPS5 Gene

  • Ribosomal Protein S5 2 3 5
  • Small Ribosomal Subunit Protein US7 3 4
  • 40S Ribosomal Protein S5 2 3
  • S5 3

External Ids for RPS5 Gene

Previous GeneCards Identifiers for RPS5 Gene

  • GC19P059797
  • GC19P059352
  • GC19P063574
  • GC19P063590
  • GC19P059040
  • GC19P059053
  • GC19P055207
  • GC19P059076
  • GC19P059095
  • GC19P059106
  • GC19P059149
  • GC19P059205
  • GC19P059246
  • GC19P059295

Summaries for RPS5 Gene

Entrez Gene Summary for RPS5 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS5 Gene

RPS5 (Ribosomal Protein S5) is a Protein Coding gene. Diseases associated with RPS5 include Retinitis Pigmentosa 14 and Chromosome 2P16.1-P15 Deletion Syndrome. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS5 Gene

Additional gene information for RPS5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS5 Gene

Genomics for RPS5 Gene

GeneHancer (GH) Regulatory Elements for RPS5 Gene

Promoters and enhancers for RPS5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I058384 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 570.8 +0.2 241 3.8 PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B RPS5 MIR4754 ZNF132 TRIM28 ZNF446
GH19I058553 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.2 +170.7 170713 7.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CHMP2A UBE2M TRIM28 ZNF417 ZNF134 ZNF606 ZNF274 MZF1 LOC100128398 ERVK3-1
GH19I058474 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.2 +89.8 89757 3.8 HNRNPUL1 PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLR2B ZNF766 ENSG00000269106 GC19P058540 GC19P058541 ZNF446 ZNF584 TRIM28 ZNF274 ZNF586 ZNF134 RPS5
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.5 -203.2 -203164 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.2 -5.3 -5315 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS5 gene promoter:

Genomic Locations for RPS5 Gene

Genomic Locations for RPS5 Gene
8,407 bases
Plus strand

Genomic View for RPS5 Gene

Genes around RPS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS5 Gene

Proteins for RPS5 Gene

  • Protein details for RPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S5
    Protein Accession:
    Secondary Accessions:
    • B2R4T2
    • Q96BN0

    Protein attributes for RPS5 Gene

    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS5 Gene

neXtProt entry for RPS5 Gene

Post-translational modifications for RPS5 Gene

  • Ubiquitination at isoforms=18, isoforms=22, posLast=4747, isoforms=63, posLast=167167, and isoforms=182
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS5 Gene

No data available for DME Specific Peptides for RPS5 Gene

Domains & Families for RPS5 Gene

Gene Families for RPS5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS7 family.
  • Belongs to the universal ribosomal protein uS7 family.
genes like me logo Genes that share domains with RPS5: view

Function for RPS5 Gene

Molecular function for RPS5 Gene

GENATLAS Biochemistry:
40S ribosomal protein S5

Phenotypes From GWAS Catalog for RPS5 Gene

Gene Ontology (GO) - Molecular Function for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 7772601
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IDA,HDA 15883184
GO:0005515 protein binding IPI 24965446
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with RPS5: view
genes like me logo Genes that share phenotypes with RPS5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS5 Gene

Localization for RPS5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA,IDA 21423176
GO:0015935 small ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPS5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS5 Gene

Pathways & Interactions for RPS5 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS5: view

Gene Ontology (GO) - Biological Process for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 7772601
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS5: view

No data available for SIGNOR curated interactions for RPS5 Gene

Drugs & Compounds for RPS5 Gene

No Compound Related Data Available

Transcripts for RPS5 Gene

Unigene Clusters for RPS5 Gene

Ribosomal protein S5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -

Relevant External Links for RPS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS5 Gene

Protein differential expression in normal tissues from HIPED for RPS5 Gene

This gene is overexpressed in Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS5 Gene

Protein tissue co-expression partners for RPS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS5 Gene:


SOURCE GeneReport for Unigene cluster for RPS5 Gene:


Evidence on tissue expression from TISSUES for RPS5 Gene

  • Intestine(4.9)
  • Liver(4.8)
  • Nervous system(4.8)
  • Lung(4.7)
  • Bone(4.6)
  • Skin(4.6)
  • Eye(4.5)
  • Pancreas(4.4)
  • Muscle(3.8)
  • Stomach(3.5)
  • Heart(3.3)
  • Kidney(3.2)
  • Blood(2.9)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Thyroid gland(2.5)
  • Spleen(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS5 Gene

Orthologs for RPS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS5 33 34
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia RPS5 34
  • 100 (a)
(Mus musculus)
Mammalia Rps5 33 16 34
  • 90.52 (n)
(Rattus norvegicus)
Mammalia Rps5 33
  • 90.03 (n)
(Canis familiaris)
Mammalia RPS5 33 34
  • 89.71 (n)
(Bos Taurus)
Mammalia RPS5 33 34
  • 89.38 (n)
(Anolis carolinensis)
Reptilia RPS5 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps5 33
  • 79.64 (n)
Str.1676 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64490 33
(Danio rerio)
Actinopterygii rps5 33 34
  • 84.41 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9001 33
fruit fly
(Drosophila melanogaster)
Insecta RpS5 35
  • 88 (a)
CG7014 35
  • 86 (a)
RpS5a 33 34
  • 77.5 (n)
RpS5b 34
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008329 33
  • 78.34 (n)
(Caenorhabditis elegans)
Secernentea rps-5 35 33 34
  • 73.6 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR171W 33
  • 68.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10659g 33
  • 65.95 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS5 33 34 36
  • 63.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS5B 33
  • 68.59 (n)
(Oryza sativa)
Liliopsida Os11g0482000 33
  • 76.19 (n)
(Triticum aestivum)
Liliopsida Ta.3277 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6156 34
  • 81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09475 33
  • 72.92 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps502 33
  • 67.02 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5398 33
Species where no ortholog for RPS5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS5 Gene

Gene Tree for RPS5 (if available)
Gene Tree for RPS5 (if available)

Paralogs for RPS5 Gene

No data available for Paralogs for RPS5 Gene

Variants for RPS5 Gene

Sequence variations from dbSNP and Humsavar for RPS5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000196076 -- 58,393,814(+) T/C intron_variant
rs1000405423 -- 58,386,928(+) G/A upstream_transcript_variant
rs1000458424 -- 58,391,341(+) A/G intron_variant
rs1000894230 -- 58,387,315(+) A/C/G 5_prime_UTR_variant
rs1000945998 -- 58,387,484(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS5 Gene

Variant ID Type Subtype PubMed ID
esv2758775 CNV loss 17122850
nsv515731 CNV gain+loss 19592680
nsv817878 CNV loss 17921354
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897
nsv961256 CNV duplication 23825009

Variation tolerance for RPS5 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS5 Gene

Disorders for RPS5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 14
  • rp14
chromosome 2p16.1-p15 deletion syndrome
  • 2p15-p16.1 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS5

genes like me logo Genes that share disorders with RPS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS5 Gene

Publications for RPS5 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio JM … Iovanna JL (Biochimica et biophysica acta 1995) 2 3 4 58
  3. [Mutual effect of human ribosomal proteins S5 and S16 on their binding with 18S rRNA fragment 1203-1236/1521-1698]. (PMID: 19807034) Ian'shina DD … Karpova GG (Molekuliarnaia biologiia 2009) 3 22 58
  4. Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. (PMID: 17901157) Galkin O … Komar AA (RNA (New York, N.Y.) 2007) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPS5 Gene

Sources for RPS5 Gene

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