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Aliases for TNFRSF17 Gene

Aliases for TNFRSF17 Gene

  • TNF Receptor Superfamily Member 17 2 3 5
  • B-Cell Maturation Protein 3 4
  • BCMA 3 4
  • BCM 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 17 2
  • Tumor Necrosis Factor Receptor Superfamily Member 17 3
  • B Cell Maturation Antigen 3
  • B-Cell Maturation Factor 3
  • CD269 Antigen 4
  • TNFRSF13A 3
  • CD269 3

External Ids for TNFRSF17 Gene

Previous HGNC Symbols for TNFRSF17 Gene

  • BCMA

Previous GeneCards Identifiers for TNFRSF17 Gene

  • GC16P011842
  • GC16P012211
  • GC16P012025
  • GC16P011966

Summaries for TNFRSF17 Gene

Entrez Gene Summary for TNFRSF17 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF17 Gene

TNFRSF17 (TNF Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include Autoimmune Disease and Common Variable Immunodeficiency. Among its related pathways are Akt Signaling and TNFs bind their physiological receptors.

UniProtKB/Swiss-Prot for TNFRSF17 Gene

  • Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Gene Wiki entry for TNFRSF17 Gene

Additional gene information for TNFRSF17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF17 Gene

Genomics for TNFRSF17 Gene

GeneHancer (GH) Regulatory Elements for TNFRSF17 Gene

Promoters and enhancers for TNFRSF17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J011963 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 657.9 +0.6 597 4.6 HDGF PKNOX1 SMAD1 RB1 STAT5A BATF KLF5 IRF4 ZNF335 ZNF121 TNFRSF17 LOC105371084 ENSG00000261560 HNRNPCP4 ZC3H7A COX6CP1 ENSG00000261216 SOCS1 TXNDC11 ENSG00000260488
GH16J011913 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -49.7 -49668 4.6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC GSPT1 PIR60564 NPIPB2 HNRNPCP4 LOC105371084 ENSG00000261560 RSL1D1 TNFRSF17 SOCS1 ENSG00000260488
GH16J011993 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +29.6 29594 2.2 L3MBTL2 MAX CBFA2T3 EBF1 MEF2B ZNF7 MITF IKZF1 MLLT1 MYC NPIPB2 TNFRSF17 TXNDC11 SNN SNX29 LITAF ZC3H7A ENSG00000260488 RPS23P6
GH16J012002 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.9 +37.6 37553 0.8 MEIS2 PKNOX1 ATF1 ZBTB21 TEAD4 JUN FOSL1 TCF12 POLR2A NCOR1 NPIPB2 TNFRSF17 ENSG00000260488 SNX29 RPS23P6
GH16J012009 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.3 +45.5 45525 2.4 FOXA2 TEAD4 TAL1 MAX EBF1 FOSL1 TCF12 ZNF766 CBFA2T2 FOS NPIPB2 TNFRSF17 SNX29 ENSG00000260488 RPS23P6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFRSF17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF17 gene promoter:
  • AP-1
  • PPAR-gamma2
  • PPAR-gamma1
  • c-Jun
  • ATF-2
  • MEF-2A
  • aMEF-2
  • HOXA9
  • HOXA9B

Genomic Locations for TNFRSF17 Gene

Genomic Locations for TNFRSF17 Gene
2,962 bases
Plus strand
2,962 bases
Plus strand

Genomic View for TNFRSF17 Gene

Genes around TNFRSF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF17 Gene

Proteins for TNFRSF17 Gene

  • Protein details for TNFRSF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 17
    Protein Accession:
    Secondary Accessions:
    • Q2TQ40

    Protein attributes for TNFRSF17 Gene

    184 amino acids
    Molecular mass:
    20165 Da
    Quaternary structure:
    • Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

    Three dimensional structures from OCA and Proteopedia for TNFRSF17 Gene

    Alternative splice isoforms for TNFRSF17 Gene


neXtProt entry for TNFRSF17 Gene

Post-translational modifications for TNFRSF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFRSF17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF17 (BCMA/TNFRSF17)
  • Abcam antibodies for TNFRSF17

Assay Products

  • Abcam assays for TNFRSF17

No data available for DME Specific Peptides for TNFRSF17 Gene

Domains & Families for TNFRSF17 Gene

Gene Families for TNFRSF17 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TNFRSF17 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF17: view

No data available for UniProtKB/Swiss-Prot for TNFRSF17 Gene

Function for TNFRSF17 Gene

Molecular function for TNFRSF17 Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 17,B cell maturation gene,expressed in terminal stages of B cell differentiation,fused with IL2 in t(4;16)(q26;p13) translocation

Gene Ontology (GO) - Molecular Function for TNFRSF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with TNFRSF17: view
genes like me logo Genes that share phenotypes with TNFRSF17: view

Animal Models for TNFRSF17 Gene

MGI Knock Outs for TNFRSF17:

Animal Model Products

miRNA for TNFRSF17 Gene

miRTarBase miRNAs that target TNFRSF17

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF17 Gene

Localization for TNFRSF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF17 Gene

Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF17 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TNFRSF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF17 Gene

Pathways & Interactions for TNFRSF17 Gene

genes like me logo Genes that share pathways with TNFRSF17: view

SIGNOR curated interactions for TNFRSF17 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0002376 immune system process IEA --
GO:0007165 signal transduction TAS 10908663
GO:0007275 multicellular organism development TAS 8165126
genes like me logo Genes that share ontologies with TNFRSF17: view

Drugs & Compounds for TNFRSF17 Gene

(4) Drugs for TNFRSF17 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
APRIL Pharma 0
BAFF Pharma 0

(2) Additional Compounds for TNFRSF17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF17: view

Transcripts for TNFRSF17 Gene

mRNA/cDNA for TNFRSF17 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF17 Gene

Tumor necrosis factor receptor superfamily, member 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF17 Gene

No ASD Table

Relevant External Links for TNFRSF17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF17 Gene

This gene is overexpressed in Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for TNFRSF17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFRSF17 Gene

Protein tissue co-expression partners for TNFRSF17 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF17 Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF17 Gene:


mRNA Expression by UniProt/SwissProt for TNFRSF17 Gene:

Tissue specificity: Expressed in mature B-cells, but not in T-cells or monocytes.

Evidence on tissue expression from TISSUES for TNFRSF17 Gene

  • Blood(4.5)
  • Lymph node(4.4)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TNFRSF17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF17 Gene

Orthologs for TNFRSF17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFRSF17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF17 34 33
  • 99.82 (n)
(Canis familiaris)
Mammalia TNFRSF17 34 33
  • 83.53 (n)
(Bos Taurus)
Mammalia TNFRSF17 33
  • 79.81 (n)
(Mus musculus)
Mammalia Tnfrsf17 16 34 33
  • 75.05 (n)
(Rattus norvegicus)
Mammalia Tnfrsf17 33
  • 74.86 (n)
(Monodelphis domestica)
Mammalia TNFRSF17 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF17 34
  • 45 (a)
Species where no ortholog for TNFRSF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF17 Gene

Gene Tree for TNFRSF17 (if available)
Gene Tree for TNFRSF17 (if available)
Evolutionary constrained regions (ECRs) for TNFRSF17: view image

Paralogs for TNFRSF17 Gene Pseudogenes for TNFRSF17 Gene

genes like me logo Genes that share paralogs with TNFRSF17: view

No data available for Paralogs for TNFRSF17 Gene

Variants for TNFRSF17 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF17 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs371163866 other, Desmoplastic small round cell tumor 11,967,816(+) C/T coding_sequence_variant, missense_variant
rs1000713202 -- 11,966,624(+) G/C intron_variant
rs1000777717 -- 11,965,609(+) A/C intron_variant
rs1001083273 -- 11,966,959(+) C/T intron_variant
rs1002798107 -- 11,963,988(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF17 Gene

Variant ID Type Subtype PubMed ID
nsv1043959 CNV gain 25217958
nsv571458 CNV gain 21841781
nsv571459 CNV loss 21841781

Variation tolerance for TNFRSF17 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF17 Gene

Disorders for TNFRSF17 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TNFRSF17 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autoimmune disease
  • hypersensitivity reaction type ii disease
common variable immunodeficiency
  • acquired agammaglobulinemia
systemic lupus erythematosus
  • sle
blue cone monochromacy
  • bcm
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. {ECO:0000269 PubMed:1396583}.

Additional Disease Information for TNFRSF17

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF17: view

No data available for Genatlas for TNFRSF17 Gene

Publications for TNFRSF17 Gene

  1. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. (PMID: 8165126) Laabi Y … Tsapis A (Nucleic acids research 1994) 2 3 4 22 58
  2. Identification of new splice variants of the genes BAFF and BCMA. (PMID: 17825416) Smirnova AS … Gerbase-DeLima M (Molecular immunology 2008) 3 4 22 58
  3. Ligand-receptor binding revealed by the TNF family member TALL-1. (PMID: 12721620) Liu Y … Zhang G (Nature 2003) 3 4 22 58
  4. Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis. (PMID: 11528522) Kawasaki A … Tokunaga K (Genes and immunity 2001) 3 4 44 58
  5. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. (PMID: 10908663) Shu HB … Johnson H (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 58

Products for TNFRSF17 Gene

Sources for TNFRSF17 Gene

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