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Aliases for RNASE6 Gene

Aliases for RNASE6 Gene

  • Ribonuclease A Family Member K6 2 3 5
  • Ribonuclease, RNase A Family, K6 2 3
  • RNase K6 2 4
  • RNS6 3 4
  • Testicular Tissue Protein Li 166 3
  • Ribonuclease A D1 3
  • Ribonuclease K6 3
  • EC 3.1.27.- 4
  • RNasek6 3
  • RAD1 3

External Ids for RNASE6 Gene

Previous HGNC Symbols for RNASE6 Gene

  • RNS6

Previous GeneCards Identifiers for RNASE6 Gene

  • GC14P018621
  • GC14P015036
  • GC14P019239
  • GC14P020319
  • GC14P021249
  • GC14P001370

Summaries for RNASE6 Gene

Entrez Gene Summary for RNASE6 Gene

  • The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

GeneCards Summary for RNASE6 Gene

RNASE6 (Ribonuclease A Family Member K6) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE7.

UniProtKB/Swiss-Prot for RNASE6 Gene

  • May have a role in host defense.

Additional gene information for RNASE6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE6 Gene

Genomics for RNASE6 Gene

GeneHancer (GH) Regulatory Elements for RNASE6 Gene

Promoters and enhancers for RNASE6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020779 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +1.0 998 4.2 PKNOX1 BACH1 STAT5A BATF IRF4 POLR2A NFATC1 EED ETV6 BCLAF1 ENSG00000258810 RNASE6 RNASE1
GH14J020714 Enhancer 1.1 FANTOM5 Ensembl ENCODE 16.9 -65.6 -65645 2.5 CTCF NFIB FEZF1 ZEB2 ZIC2 OSR2 ZNF335 RBAK POLR2A GLIS1 EDDM3A RNASE6 ENSG00000258515 METTL3 SUPT16H METTL17 EDDM3B RNASE1 ANG ARHGEF40
GH14J020819 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.1 +40.1 40140 2.6 HDAC1 ATF1 TAF9B ARNT NFRKB SIN3A CHAMP1 ZNF280A TCF12 CBX5 HNRNPC EDDM3B RNASE6 ENSG00000178107 SUPT16H CHD8 APEX1 GC14P020814 ENSG00000259130
GH14J020719 Enhancer 0.5 ENCODE 15 -61.1 -61125 1.3 SMARCE1 ZNF217 CTBP1 GATA3 DPF2 GC14M020723 PIR39681 RNASE6 EDDM3A EDDM3B RNASE1 ANG ENSG00000258451
GH14J021068 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.3 +290.0 289994 5 HDGF ARID4B SIN3A DMAP1 ZBTB7B ZNF213 E2F8 ZNF143 FOS PAF1 ARHGEF40 NDRG2 METTL3 SUPT16H METTL17 CHD8 PIP4P1 ENSG00000258515 TEP1 TMEM253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNASE6 gene promoter:
  • Zic3
  • LCR-F1
  • Brachyury
  • HSF2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for RNASE6 Gene

Genomic Locations for RNASE6 Gene
1,417 bases
Plus strand
1,417 bases
Plus strand

Genomic View for RNASE6 Gene

Genes around RNASE6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE6 Gene

Proteins for RNASE6 Gene

  • Protein details for RNASE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease K6
    Protein Accession:

    Protein attributes for RNASE6 Gene

    150 amino acids
    Molecular mass:
    17196 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE6 Gene

neXtProt entry for RNASE6 Gene

Post-translational modifications for RNASE6 Gene

  • Glycosylation at Asn100 and Asn55

Other Protein References for RNASE6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE6 Gene

Domains & Families for RNASE6 Gene

Gene Families for RNASE6 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE6 Gene

Suggested Antigen Peptide Sequences for RNASE6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE6: view

Function for RNASE6 Gene

Molecular function for RNASE6 Gene

UniProtKB/Swiss-Prot Function:
May have a role in host defense.
GENATLAS Biochemistry:
ribonuclease RNAse A family,k6,ubiquitously expressed

Enzyme Numbers (IUBMB) for RNASE6 Gene

Gene Ontology (GO) - Molecular Function for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity TAS,IDA 9826755
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RNASE6: view
genes like me logo Genes that share phenotypes with RNASE6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNASE6

CRISPR Products

miRNA for RNASE6 Gene

miRTarBase miRNAs that target RNASE6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE6

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE6 Gene

Localization for RNASE6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE6 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 25075772
GO:0005622 intracellular IDA 25075772
GO:0031410 cytoplasmic vesicle IDA 25075772
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with RNASE6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE6 Gene

Pathways & Interactions for RNASE6 Gene

genes like me logo Genes that share pathways with RNASE6: view

Pathways by source for RNASE6 Gene

3 Reactome pathways for RNASE6 Gene

Interacting Proteins for RNASE6 Gene

Gene Ontology (GO) - Biological Process for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process TAS 8836175
GO:0006952 defense response TAS 8836175
GO:0019730 antimicrobial humoral response TAS --
GO:0019731 antibacterial humoral response IDA 25075772
GO:0045087 innate immune response IDA 25075772
genes like me logo Genes that share ontologies with RNASE6: view

No data available for SIGNOR curated interactions for RNASE6 Gene

Drugs & Compounds for RNASE6 Gene

(1) Drugs for RNASE6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNASE6: view

Transcripts for RNASE6 Gene

mRNA/cDNA for RNASE6 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE6 Gene

Ribonuclease, RNase A family, k6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE6

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE6 Gene

No ASD Table

Relevant External Links for RNASE6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE6 Gene

This gene is overexpressed in Whole Blood (x16.0) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for RNASE6 Gene

This gene is overexpressed in Kidney (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE6 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE6 Gene:


SOURCE GeneReport for Unigene cluster for RNASE6 Gene:


mRNA Expression by UniProt/SwissProt for RNASE6 Gene:

Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.
genes like me logo Genes that share expression patterns with RNASE6: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE6 Gene

Orthologs for RNASE6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE6 34 33
  • 99.56 (n)
(Bos Taurus)
Mammalia RNASE6 34 33
  • 79.32 (n)
(Mus musculus)
Mammalia Rnase6 16 34 33
  • 76.23 (n)
(Rattus norvegicus)
Mammalia Rnase6 33
  • 75.25 (n)
(Canis familiaris)
Mammalia RNASE6 34
  • 44 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
(Gallus gallus)
Aves RSFR 34
  • 24 (a)
CL2 34
  • 23 (a)
ANG 34
  • 23 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
-- 34
  • 23 (a)
Species where no ortholog for RNASE6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE6 Gene

Gene Tree for RNASE6 (if available)
Gene Tree for RNASE6 (if available)
Evolutionary constrained regions (ECRs) for RNASE6: view image

Paralogs for RNASE6 Gene

Paralogs for RNASE6 Gene

(5) SIMAP similar genes for RNASE6 Gene using alignment to 2 proteins:

  • Q6IB39_HUMAN
genes like me logo Genes that share paralogs with RNASE6: view

Variants for RNASE6 Gene

Sequence variations from dbSNP and Humsavar for RNASE6 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000970376 -- 20,780,067(+) A/G upstream_transcript_variant
rs1001974069 -- 20,781,581(+) T/G intron_variant
rs1002404188 -- 20,781,227(+) T/C 5_prime_UTR_variant, intron_variant
rs1002960717 -- 20,782,780(+) C/A/T downstream_transcript_variant
rs1003287689 -- 20,780,396(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE6 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545
esv2759972 CNV gain+loss 17122850
nsv428293 CNV gain+loss 18775914

Variation tolerance for RNASE6 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE6 Gene

Disorders for RNASE6 Gene

Additional Disease Information for RNASE6

No disorders were found for RNASE6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE6 Gene

Publications for RNASE6 Gene

  1. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PMID: 8836175) Rosenberg HF … Dyer KD (Nucleic acids research 1996) 2 3 4 22 58
  2. Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PMID: 9647635) Deming MS … Rosenberg HF (Genome research 1998) 2 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus. (PMID: 9826755) Domachowske JB … Rosenberg HF (Nucleic acids research 1998) 3 22 58
  5. Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation. (PMID: 27089320) Pulido D … Boix E (International journal of molecular sciences 2016) 3 58

Products for RNASE6 Gene

Sources for RNASE6 Gene

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