Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS13 Gene

Aliases for RGS13 Gene

  • Regulator Of G Protein Signaling 13 2 3 5
  • Regulator Of G-Protein Signalling 13 2 3
  • Regulator Of G-Protein Signaling 13 2 3

External Ids for RGS13 Gene

Previous GeneCards Identifiers for RGS13 Gene

  • GC01P190395
  • GC01P188119
  • GC01P189071
  • GC01P189893
  • GC01P189336
  • GC01P190871
  • GC01P163841

Summaries for RGS13 Gene

Entrez Gene Summary for RGS13 Gene

  • The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS13 Gene

RGS13 (Regulator Of G Protein Signaling 13) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS4.

UniProtKB/Swiss-Prot for RGS13 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).

Gene Wiki entry for RGS13 Gene

Additional gene information for RGS13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS13 Gene

Genomics for RGS13 Gene

GeneHancer (GH) Regulatory Elements for RGS13 Gene

Promoters and enhancers for RGS13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J192608 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.4 -26.7 -26745 1.3 PKNOX1 SMAD1 RB1 BMI1 BATF RAD21 KLF5 IRF4 ZNF207 ZNF143 RGS13 RGS1 TROVE2 RGS2 GC01P192596 LOC105371664 ENSG00000285280
GH01J192636 Promoter 0.6 EPDnew 650.7 +0.0 1 0.1 POLR2A RGS13 ENSG00000231767 ENSG00000285280
GH01J192639 Enhancer 1.1 FANTOM5 Ensembl ENCODE 27 +4.0 3960 2 STAT5A EBF1 BATF RELA ZNF366 NFATC1 FOSL2 ETV6 NR2F1 HLF RGS13 RGS1 RGS2 ENSG00000231767 ENSG00000285280
GH01J192605 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.5 -30.9 -30931 0.3 PKNOX1 SMAD1 MAX PAX8 EBF1 BMI1 ATF7 IKZF2 RUNX3 CREM RGS1 RGS13 TROVE2 RGS2 GC01P192596 LOC105371664 ENSG00000285280
GH01J192699 Enhancer 1.1 Ensembl ENCODE 10.1 +65.4 65360 3.6 PKNOX1 FOXA2 ARID4B FOS RXRA REST PPARG KAT8 NFIL3 MAFF RGS13 RGS2 ENSG00000231767 ENSG00000285280
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS13 gene promoter:
  • STAT1
  • POU2F1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for RGS13 Gene

Genomic Locations for RGS13 Gene
24,174 bases
Plus strand
24,174 bases
Plus strand

Genomic View for RGS13 Gene

Genes around RGS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS13 Gene

Proteins for RGS13 Gene

  • Protein details for RGS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 13
    Protein Accession:
    Secondary Accessions:
    • Q6PGR2
    • Q8TD63
    • Q9BX45

    Protein attributes for RGS13 Gene

    159 amino acids
    Molecular mass:
    19135 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RGS13 Gene

Post-translational modifications for RGS13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS13 Gene

Domains & Families for RGS13 Gene

Gene Families for RGS13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS13 Gene

Suggested Antigen Peptide Sequences for RGS13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS13: view

No data available for UniProtKB/Swiss-Prot for RGS13 Gene

Function for RGS13 Gene

Molecular function for RGS13 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).

Gene Ontology (GO) - Molecular Function for RGS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RGS13: view
genes like me logo Genes that share phenotypes with RGS13: view

Animal Models for RGS13 Gene

MGI Knock Outs for RGS13:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS13

miRNA for RGS13 Gene

miRTarBase miRNAs that target RGS13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS13 Gene

Localization for RGS13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS13 gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 3
extracellular 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RGS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RGS13 Gene

Pathways & Interactions for RGS13 Gene

genes like me logo Genes that share pathways with RGS13: view

Pathways by source for RGS13 Gene

3 Qiagen pathways for RGS13 Gene

Gene Ontology (GO) - Biological Process for RGS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA --
genes like me logo Genes that share ontologies with RGS13: view

No data available for SIGNOR curated interactions for RGS13 Gene

Drugs & Compounds for RGS13 Gene

No Compound Related Data Available

Transcripts for RGS13 Gene

mRNA/cDNA for RGS13 Gene

Unigene Clusters for RGS13 Gene

Regulator of G-protein signaling 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP2: -

Relevant External Links for RGS13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS13 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.7) and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for RGS13 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS13 Gene

Protein tissue co-expression partners for RGS13 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS13 Gene:


SOURCE GeneReport for Unigene cluster for RGS13 Gene:


Evidence on tissue expression from TISSUES for RGS13 Gene

  • Lung(4.1)
  • Nervous system(4)
  • Lymph node(2.6)
genes like me logo Genes that share expression patterns with RGS13: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS13 Gene

Orthologs for RGS13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS13 34 33
  • 99.58 (n)
(Canis familiaris)
Mammalia RGS13 34 33
  • 92.62 (n)
(Mus musculus)
Mammalia Rgs13 16 34 33
  • 85.44 (n)
(Rattus norvegicus)
Mammalia Rgs13 33
  • 84.93 (n)
(Bos Taurus)
Mammalia RGS13 34
  • 83 (a)
(Monodelphis domestica)
Mammalia RGS13 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia RGS13 34
  • 68 (a)
(Gallus gallus)
Aves RGS13 34 33
  • 66.88 (n)
(Anolis carolinensis)
Reptilia RGS13 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs13 33
  • 66.67 (n)
(Danio rerio)
Actinopterygii si:ch211-117l17.5 34
  • 42 (a)
rgs13 34
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5036 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea rgs-2 34
  • 31 (a)
rgs-1 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
Species where no ortholog for RGS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS13 Gene

Gene Tree for RGS13 (if available)
Gene Tree for RGS13 (if available)
Evolutionary constrained regions (ECRs) for RGS13: view image

Paralogs for RGS13 Gene

Paralogs for RGS13 Gene

(19) SIMAP similar genes for RGS13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS13: view

Variants for RGS13 Gene

Sequence variations from dbSNP and Humsavar for RGS13 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000049431 -- 192,658,805(+) G/A/T intron_variant
rs1000298691 -- 192,648,318(+) C/A intron_variant
rs1000363763 -- 192,646,877(+) C/T intron_variant
rs1000376043 -- 192,653,143(+) T/C intron_variant
rs1000498194 -- 192,647,173(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS13 Gene

Variant ID Type Subtype PubMed ID
esv1739511 CNV deletion 17803354
esv2283787 CNV deletion 18987734
esv2720762 CNV deletion 23290073
esv2720773 CNV deletion 23290073
esv2720784 CNV deletion 23290073
esv2720795 CNV deletion 23290073
esv2720807 CNV deletion 23290073
esv3003020 CNV deletion 24192839
esv3424496 CNV insertion 20981092
esv3544289 CNV deletion 23714750
esv991606 CNV deletion 20482838
nsv1133927 CNV deletion 24896259
nsv466994 CNV loss 19166990
nsv467005 CNV gain 19166990
nsv548658 CNV loss 21841781
nsv548659 CNV gain 21841781
nsv548660 CNV gain 21841781

Variation tolerance for RGS13 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS13 Gene

Disorders for RGS13 Gene

Additional Disease Information for RGS13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS13 Gene

Publications for RGS13 Gene

  1. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 44 58
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Functional characterization of the G protein regulator RGS13. (PMID: 11875076) Johnson EN … Druey KM (The Journal of biological chemistry 2002) 2 3 58

Products for RGS13 Gene

Sources for RGS13 Gene

Loading form....